Published in JCI Insight
Complement C4-derived Man5GlcNAc2 glycopeptide is identified as a potential biomarker from serum of a large cohort of individuals with PMM2-congenital disorder of glycosylation.
Published in Psychiatria polska
The aim of the study was to assess the well-being of corporate employees and whether it has changed from the beginning of the first wave of COVID-19 (March) to the development of the second wave of the disease (October). The essence of the study was to estimate the risk of depressive symptoms in the studied population. The study involved 250 corpor...
Published in JCI Insight
Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we used a simple model of folic acid–induced kidney injury in 7 highly diverse mouse strains. We...
Published in JCI insight
Multiple randomized, controlled clinical trials have yielded discordant results regarding the efficacy of convalescent plasma in outpatients, with some showing an approximately 2-fold reduction in risk and others showing no effect. We quantified binding and neutralizing antibody levels in 492 of the 511 participants from the Clinical Trial of COVID...
Published in JCI insight
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 health...
Published in JCI Insight
HIV-1 usually utilizes CCR5 as its coreceptor and rarely switches to a CXCR4-tropic virus until the late stage of infection. CCR5+CD4+ T cells are the major virus-producing cells in viremic individuals as well as SIV-infected nonhuman primates. The differentiation of CCR5+CD4+ T cells is associated with the availability of IL-15, which increases du...
Published in JCI Insight
Published in JCI Insight
Published in JCI Insight
Published in JCI Insight
