Lanzolla, Giulia Merceron, Christophe Khan, Mohd Parvez Sabini, Elena Giaccia, Amato Schipani, Ernestina
Published in
JBMR plus
Erythropoietin (EPO), primarily produced by interstitial fibroblasts in the kidney during adulthood, and its receptor are well-known for their crucial role in regulating erythropoiesis. Recent research has unveiled an additional function of circulating EPO in the control of bone mass accrual and homeostasis through its receptor, which is expressed ...
Das, Bhaba K Minocha, Tarun Kunika, Mikaela D Kannan, Aarthi Gao, Ling Mohan, Subburaman Xing, Weirong Varughese, Kottayil I Zhao, Haibo
Published in
JBMR plus
Mutations in PLEKHM1 cause osteopetrosis in humans and rats. The germline and osteoclast conditional deletions of Plekhm1 gene in mice lead to defective osteoclast bone resorption and increased trabecular bone mass without overt abnormalities in other organs. As an adaptor protein, pleckstrin homology and RUN domain containing M1 (PLEKHM1) interact...
Schoeb, Manuela Avci, Telli M Winter, Elizabeth M Appelman-Dijkstra, Natasha M
Published in
JBMR plus
Impact microindentation (IMI) is a technique to assess bone material properties of the cortical bone at the tibia in a transcutaneous, microinvasive, way. IMI is increasingly used in studies evaluating the contribution of tissue material properties to bone fragility in humans, and is approved for use in the clinic in Europe and the United States. P...
Reyes, Monica Firat, Damla Hanna, Patrick Khan, Mohd Bruce, Michael Shvedova, Maria Kobayashi, Tatsuya Schipani, Ernestina Gardella, Thomas J Jüppner, Harald
...
Published in
JBMR plus
Activating parathyroid hormone (PTH)/PTH-related Peptide (PTHrP) receptor (PTH1R) mutations causes Jansen's metaphyseal chondrodysplasia (JMC), a rare disease characterized by growth plate abnormalities, short stature, and PTH-independent hypercalcemia. Previously generated transgenic JMC mouse models, in which the human PTH1R allele with the H223R...
Doolittle, Madison L Khosla, Sundeep Saul, Dominik
Published in
JBMR plus
The regulation of bone mineral density (BMD) is highly influenced by genetics and age. Although genome-wide association studies (GWAS) for BMD have uncovered many genes through their proximity to associated variants (variant nearest-neighbor [VNN] genes), the cell-specific mechanisms of each VNN gene remain unclear. This is primarily due to the ina...
Doolittle, Madison L Eckhardt, Brittany A Vos, Stephanie J Grain, Sarah Rowsey, Jennifer L Ruan, Ming Saul, Dominik Farr, Joshua N Weivoda, Megan M Khosla, Sundeep
...
Published in
JBMR plus
Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for skeletal estrogen action. Previous studies using either global or cell-specific ERα deletion provided important i...
Heck, Ansgar Godang, Kristin Lekva, Tove Markussen, Kjersti Norman De Vincentis, Sara Ueland, Thor Bollerslev, Jens
Published in
JBMR plus
Growth hormone (GH) is nonphysiologically increased in acromegaly, stimulating target tissues directly and indirectly via insulin-like growth factor type 1 (IGF-1). Despite GH having anabolic effects on bone growth and renewal, the risk of vertebral fractures is paradoxically increased in acromegaly. We hypothesized that bone tissue compartments we...
Spangler, Leslie Nielson, Carrie M Brookhart, M Alan Hernandez, Rohini K Stad, Robert Kees Lin, Tzu-Chieh
Published in
JBMR plus
Osteoporosis and cardiovascular disease are common in older adults. Treatment of osteoporosis reduces the burden of debilitating fractures; however, it is important to understand the benefit versus risk of treatment. This study evaluates the risk of stroke (ischemic or hemorrhagic) and myocardial infarction (MI) among postmenopausal women and men i...
Ganesan, Calyani Thomas, I-Chun Montez-Rath, Maria E Chertow, Glenn M Leppert, John T Pao, Alan C
Published in
JBMR plus
Patients with kidney stone disease are at higher risk for bone disease. Hypocitraturia is common in patients with kidney stone disease and a key risk factor for stone recurrence. In this retrospective cohort study, we sought to determine whether hypocitraturia is also a risk factor for incident bone disease in patients with kidney stone disease. We...
Cheng, Jonathan H Hoofnagle, Andrew N Katz, Ronit Kritchevsky, Stephen B Shlipak, Michael G Sarnak, Mark J Ix, Joachim H Ginsberg, Charles
Published in
JBMR plus
Vitamin D deficiency is prevalent in 25% of Americans. However, 25(OH)D may not be an accurate measure of vitamin D because the majority (85%-90%) of 25(OH)D is bound to vitamin D binding protein (VDBP), which varies by over 30% across individuals. Free 25(OH)D may be a better measure, but it is difficult to measure accurately and precisely. The ex...
