Lauterlein, Jens‐Jacob Lindegaard Gossiel, Fatma Weigl, Moritz Eastell, Richard Hackl, Matthias Hermann, Pernille Bollerslev, Jens Frost, Morten
Published in
JBMR Plus
Pathogenic variants in the Wnt‐pathway co‐receptor low‐density lipoprotein (LDL) receptor‐related protein 5 (LRP5) cause high bone mass (LRP5‐HBM) due to insensitivity to the endogenous antagonist of Wnt‐signaling. Although indicating incessant progression of BMD and biomarkers reflecting bone formation, this has not been confirmed in individuals w...
McDonald, Michelle Maree Kim, Albert Sungsoo Mulholland, Bridie S Rauner, Martina
Published in
JBMR Plus
Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb large quantities of bone. Therefore, they are frequently the target of therapeutic interventions to ameliorate bone loss. In an adult organism, osteoclasts derive from hematopoietic stem cells and differentiate into osteoclasts within a multistep process u...
Johnson, Rachelle W. Weivoda, Megan M.
Published in
JBMR Plus
Griffin, Lanny V. Warner, Elizabeth Palnitkar, Saroj Qiu, Shijing Honasoge, Mahalakshmi Griffin, Shawna G. Divine, George Rao, Sudhaker D.
Published in
JBMR Plus
Atypical femur fractures (AFFs) are well‐established serious complication of long‐term bisphosphonate and denosumab therapy in patients with osteopenia or osteoporosis. To elucidate underlying mechanism(s) for the development of AFF, we performed a nested case‐control study to investigate bone tissue nanomechanical properties and prevailing bone mi...
Baleanu, Felicia Iconaru, Laura Charles, Alexia Kinnard, Virginie Fils, Jean‐François Moreau, Michel Karmali, Rafik Surquin, Murielle Benoit, Florence Mugisha, Aude
...
Published in
JBMR Plus
Probabilistic models including clinical risk factors with or without bone mineral density (BMD) have been developed to estimate the 5‐ or 10‐year absolute fracture risk. We investigated the performance of the FRAX and Garvan tools in a well‐characterized population‐based cohort of 3560 postmenopausal, volunteer women, aged 60 to 85 years at baselin...
Greene, Benjamin Russo, Ryan J Dwyer, Shannon Malley, Katie Roberts, Errin Serrielo, Joseph Piepenhagen, Peter Cummings, Sheila Ryan, Susan Zarazinski, Christine
...
Published in
JBMR Plus
Osteogenesis imperfecta (OI), is a genetic disorder of bone fragility caused by mutations in collagen I or proteins involved in collagen processing. Previous studies in mice and human OI bones have shown that excessive activation of TGF‐β signaling plays an important role in dominant and recessive OI disease progression. Inhibition of TGF‐β signali...
Edwards, Daniel F. III Miller, Christopher J. Quintana‐Martinez, Arelis Wright, Christian S. Prideaux, Matthew Atkins, Gerald J. Thompson, William R. Clinkenbeard, Erica L.
Published in
JBMR Plus
Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the balance of osteoblast and adipocyte differe...
Pippin, James A Chesi, Alessandra Wagley, Yadav Su, Chun Pahl, Matthew C Hodge, Kenyaita M Johnson, Matthew E Wells, Andrew D Hankenson, Kurt D Grant, Struan F A
...
Published in
JBMR Plus
Genome‐wide–association studies (GWASs) have discovered genetic signals robustly associated with BMD, but typically not the precise localization of effector genes. By intersecting genome‐wide promoter‐focused Capture C and assay for transposase‐accessible chromatin using sequencing (ATAC‐seq) data generated in human mesenchymal progenitor cell (hMS...
Casanova, Michele Schindeler, Aaron Peacock, Lauren Lee, Lucinda Schneider, Philipp Little, David G. Müller, Ralph
Published in
JBMR Plus
Fracture repair is a normal physiological response to bone injury. During the process of bony callus formation, a lacunocanalicular network (LCN) is formed de novo that evolves with callus remodeling. Our aim was the longitudinal assessment of the development and evolution of the LCN during fracture repair. To this end, 45 adult wild‐type C57BL/6 m...
Gerber, Claire Wang, Xueyan David, Valentin Quaggin, Susan E. Isakova, Tamara Martin, Aline
Published in
JBMR Plus
Sodium‐glucose cotransporter 2 (SGLT2) inhibitors improve kidney and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM). However, bone fragility has emerged as a side effect in some but not in all human studies. Because use of SGLT2 inhibitors in humans affects mineral metabolism, we investigated the long‐term effects of genet...
