Yoneda, Zachary T. Anderson, Katherine C. Ye, Fei Quintana, Joseph A. O’Neill, Matthew J. Sims, Richard A. Sun, Lili Glazer, Andrew M. Davogustto, Giovanni El-Harasis, Majd
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Published in
JAMA Cardiology
Importance Patients with early-onset atrial fibrillation (AF) are enriched for rare variants in cardiomyopathy and arrhythmia genes. The clinical significance of these rare variants in patients with early-onset AF is unknown. Objective To assess the association between rare variants in cardiomyopathy and arrhythmia genes detected in patients with e...
Karlstad, Øystein Hovi, Petteri Husby, Anders Härkänen, Tommi Selmer, Randi Marie Pihlström, Nicklas Hansen, Jørgen Vinsløv Nohynek, Hanna Gunnes, Nina Sundström, Anders
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Published in
JAMA Cardiology
This cohort study conducted using nationwide registers assesses the risks of myocarditis and pericarditis after SARS-CoV-2 messenger RNA vaccinations in a combined population of 23.1 million individuals across Denmark, Finland, Norway, and Sweden.
Kuroda, Masaru Tamiya, Eiji Nose, Takahisa Ogimoto, Akiyoshi Taura, Junki Imamura, Yuki Fukuzawa, Masayuki Hayashi, Takuya Akao, Masaharu Yamashita, Takeshi
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Published in
JAMA Cardiology
Importance Long-term use of oral anticoagulants (OACs) is necessary for stroke prevention in patients with atrial fibrillation (AF). The effectiveness and safety of OACs in extremely older patients (ie, aged 80 years or older) with AF and at high risk of bleeding needs to be elucidated. Objective To examine the effects of very low-dose edoxaban (15...
Gasperetti, Alessio Cappelletto, Chiara Carrick, Richard Targetti, Mattia Tichnell, Crystal Martino, Annamaria Murray, Brittney Compagnucci, Paolo Stolfo, Davide Bisson, Jasmine
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Published in
JAMA cardiology
A high burden of premature ventricular contractions (PVCs) at disease diagnosis has been associated with an overall higher risk of ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC). Data regarding dynamic modification of PVC burden at follow-up with Holter monitoring and its impact on arrhythmic risk in ARVC are scar...
Duffy, Grant Cheng, Paul P Yuan, Neal He, Bryan Kwan, Alan C Shun-Shin, Matthew J Alexander, Kevin M Ebinger, Joseph Lungren, Matthew P Rader, Florian
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Published in
JAMA cardiology
Early detection and characterization of increased left ventricular (LV) wall thickness can markedly impact patient care but is limited by under-recognition of hypertrophy, measurement error and variability, and difficulty differentiating causes of increased wall thickness, such as hypertrophy, cardiomyopathy, and cardiac amyloidosis. To assess the ...
Cannatà, Antonio Merlo, Marco Dal Ferro, Matteo Barbati, Giulia Manca, Paolo Paldino, Alessia Graw, Sharon Gigli, Marta Stolfo, Davide Johnson, Renee
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Published in
JAMA cardiology
Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little is known about the genetic underpinnings of the growing numbers of patients with DCM who are diagnosed when they are older than 60 years (ie, late-onset DCM). To investigate ...
Lee, Yi-Ting Hana Fang, Jing Schieb, Linda Park, Soyoun Casper, Michele Gillespie, Cathleen
Published in
JAMA cardiology
Hadziselimovic, Edina Greve, Anders M Sajadieh, Ahmad Olsen, Michael H Kesäniemi, Y Antero Nienaber, Christoph A Ray, Simon G Rossebø, Anne B Willenheimer, Ronnie Wachtell, Kristian
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Published in
JAMA cardiology
Recent studies have questioned the presumed low-risk status of patients with asymptomatic nonsevere aortic stenosis (AS). Whether annual N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements are useful for risk assessment is unknown. To assess the association of annual NT-proBNP measurements with clinical outcomes in patients with nonse...
Zekavat, Seyedeh Maryam Chou, Elizabeth L Zekavat, Melica Pampana, Akhil Paruchuri, Kaavya Lino Cardenas, Christian Lacks Koyama, Satoshi Ghazzawi, Yousef Kii, Erina Uddin, Md Mesbah
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Published in
JAMA cardiology
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized nonatherosclerotic cause of acute myocardial infarction enriched among individuals with early-onset myocardial infarction but is of unclear etiology. To assess which genes contribute to the development of SCAD. To prioritize genes influencing risk for SCAD, whole-exome sequ...
Markman, Timothy M Pothineni, Naga Venkata K Zghaib, Tarek Smietana, Jeffrey McBride, Daniel Amankwah, Nigel A Linn, Kristin A Kumareswaran, Ramanan Hyman, Matthew Arkles, Jeffrey
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Published in
JAMA cardiology
Autonomic neuromodulation provides therapeutic benefit in ventricular tachycardia (VT) storm. Transcutaneous magnetic stimulation (TcMS) can noninvasively and nondestructively modulate a patient's nervous system activity and may reduce VT burden in patients with VT storm. To evaluate the safety and efficacy of TcMS of the left stellate ganglion for...
