Taieb, Julien Le Malicot, Karine Shi, Qian Penault-Llorca, Frédérique Bouché, Olivier Tabernero, Josep Mini, Enrico Goldberg, Richard M Folprecht, Gunnar Luc Van Laethem, Jean
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Published in
Journal of the National Cancer Institute
The prognostic value of BRAF and KRAS mutations within microsatellite-unstable (MSI) and microsatellite-stable (MSS) subgroups of resected colon carcinoma patients remains controversial. We examined this question in prospectively collected biospecimens from stage III colon cancer with separate analysis of MSI and MSS tumors from patients receiving ...
Schleiermacher, Gudrun Delattre, Olivier
Published in
Journal of the National Cancer Institute
Ferris, Robert L Galon, Jérôme
Published in
Journal of the National Cancer Institute
Tougeron, David Mouillet, Guillaume Trouilloud, Isabelle Lecomte, Thierry Coriat, Romain Aparicio, Thomas Des Guetz, Gaetan Lécaille, Cédric Artru, Pascal Sickersen, Gaelle
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Published in
Journal of the National Cancer Institute
Deficient mismatch repair (dMMR) colon cancer (CC) is reportedly resistant to 5-fluorouracil (5FU) adjuvant chemotherapy while preliminary data suggest chemosensitivity to oxaliplatin. We assessed the efficacy of fluoropyrimidine with and without oxaliplatin in a large cohort of dMMR CC patients. This retrospective multicenter study included all co...
Le Tourneau, Christophe Kamal, Maud Tsimberidou, Apostolia-Maria Bedard, Philippe Pierron, Gaëlle Callens, Céline Rouleau, Etienne Vincent-Salomon, Anne Servant, Nicolas Alt, Marie
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Published in
Journal of the National Cancer Institute
With the advent of high-throughput molecular technologies, several precision medicine (PM) studies are currently ongoing that include molecular screening programs and PM clinical trials. Molecular profiling programs establish the molecular profile of patients' tumors with the aim to guide therapy based on identified molecular alterations. The aim o...
Sutherland, Ashley Forsyth, Amanda Cong, Yingying Grant, Laurel Juan, Tzu-Hua Lee, Jae K Klimowicz, Alexander Petrillo, Stephanie K Hu, Jinghui Chan, Angela
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Published in
Journal of the National Cancer Institute
Our evidence indicates that PRL-PRLR can escalate the impact of breast cancer on bone metastasis and that the presence of the PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.
Sutherland, Ashley Forsyth, Amanda Cong, Yingying Grant, Laurel Juan, Tzu-Hua Lee, Jae K. Klimowicz, Alexander Petrillo, Stephanie K. Hu, Jinghui Chan, Angela
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Published in
J Natl Cancer Inst
Ferris, Robert L. Jérôme Galon
Published in
J Natl Cancer Inst
Saiag, Philippe Aegerter, Philippe Vitoux, Dominique Lebbé, Celeste Wolkenstein, Pierre Dupin, Nicolas Descamps, Vincent Aractingi, Selim Funck-Brentano, Elisa Autier, Philippe
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Published in
J Natl Cancer Inst
Gibert, Benjamin Delloye-Bourgeois, Céline Gattolliat, Charles-Henry Meurette, Olivier Le Guernevel, Solen Fombonne, Joanna Ducarouge, Benjamin Lavial, Fabrice Bouhallier, Frantz Creveaux, Marion
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Published in
Journal of viral hepatitis
Together, these data support the view that CDON acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.