Chai, Nannan Zheng, Haihong Zhang, Hao Li, Lingxu Yu, Xue Wang, Liyi Bi, Xin Yang, Lihong Niu, Tongxu Liu, Xiujuan
...
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Background Intrauterine hypoxia (IUH) increases the risk of cardiovascular diseases in offspring. As a reactive oxygen species (ROS) scavenger, polyamine spermidine (SPD) is essential for embryonic and fetal survival and growth. However, further studies on the SPD protection and mechanisms for IUH-induced heart damage in offspring are required. Obj...
Mahjoub, Mohammad Ali Dadashzadeh, Simin Haeri, Azadeh Shahhosseini, Soraya Abbasian, Zahra Nowroozi, Fatemeh
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Iranian journal of pharmaceutical research : IJPR
Despite the advantages of direct intratumoral (IT) injection, the relatively rapid withdrawal of most anti-cancer drugs from the tumor due to their small molecular size limits the effectiveness of this method of administration. To address these limitations, recently, increasing attention has been directed to using slow-release biodegradable deliver...
Afshar, Shima Khalili, Shayesteh Amin, Gholamreza Abbasinazari, Mohammad
Published in
Iranian Journal of Pharmaceutical Research : IJPR
The current study aimed to evaluate the safety profile and efficacy of a cannabis-based sublingual spray, CBDEX10® (containing 100 µg cannabidiol and 10 µg Δ9-tetrahydrocannabinol per puff; CBD/Δ9-THC 10:1), in improving lipid profile and glycemic state of the diabetic patients. Fifty diabetic patients were randomly allocated to the treatment (n = ...
Khosropanah, Mohammad Hossein Majidi Zolbin, Masoumeh Kajbafzadeh, Abdol-Mohammad Amani, Leili Harririan, Ismaeil Azimzadeh, Ashkan Nejatian, Touraj Alizadeh Vaghsloo, Mahdi Hassannejad, Zahra
Published in
Iranian journal of pharmaceutical research : IJPR
Silkworm products were first used by physicians more than 8500 years ago, in the early Neolithic period. In Persian medicine, silkworm extract has several uses for treating and preventing neurological, cardiac, and liver diseases. Mature silkworms (Bombyx mori) and their pupae contain a variety of growth factors and proteins that can be used in man...
Ebrahimoghli, Reza Janati, Ali Gharaee, Hojatolah Aghaei, Mir Hossein
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Background Polypharmacy is a significant patient safety concern. Objectives This study aims to estimate the prevalence of polypharmacy, its continuity and associated factors, and common medication classes among a large outpatient population in East Azerbaijan province, Iran. Methods A retrospective prescription data analysis was performed. The coho...
Damough, Shadi Alizadeh, Reyhaneh Komijani, Samira Shirin, Mahsa Adeli, Ahmad Mafakher, Ladan Mahboudi, Fereidoun Talebkhan Garoosi, Yeganeh
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Background Overexpression of CD20 protein on the surface of B cells in lymphoma can be targeted by several anti-CD20 molecules. The development of accessible interactive epitopes is more favorable than the full-length transmembrane CD20 in the affinity assessment of anti-CD20 monoclonal antibodies (mAbs). Methods The sequence of these epitopes was ...
Feizabadi, Faezeh Abedini, Atefeh Salamzadeh, Jamshid Barati, Saghar Dastan, Farzaneh
Published in
Iranian journal of pharmaceutical research : IJPR
The symptoms of pulmonary sarcoidosis may lead to fatigue, excessive daytime sleepiness, poor sleep quality, and a decrease in quality of life in these patients. This study was designed to evaluate the effects of oral melatonin on sleep disorders of patients with pulmonary sarcoidosis. A randomized, single-blinded clinical trial was conducted on pa...
Cheshmehnoor, Pegah Bolourchian, Noushin Abdollahizad, Erfan Derakhshi, Arash Dadashzadeh, Simin Haeri, Azadeh
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Background A large number of new substances have insufficient biopharmaceutical properties for oral administration caused by their slow dissolution rate and poor solubility. Objective The purpose of our experiment was to improve the physicochemical properties of a hydrophobic drug, quercetin, by the nanomilling approach. Methods Quercetin nanosuspe...
Demir, Enver Ahmet Tutuk, Okan Dogan-Gocmen, Hatice Ozyilmaz, Duygu Seren Karagul, Meryem Ilkay Kara, Mikail Temiz, Muhyittin Tumer, Cemil
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Iranian Journal of Pharmaceutical Research : IJPR
Background Hepatic ischemia/reperfusion injury is a major problem that can exacerbate complications, particularly in liver transplantations. Objectives This study aimed to investigate the cellular mechanisms of ischemia/reperfusion injury and hepatoprotection by curcumin. Methods Wistar albino rats were divided into four groups as Control, Sham, I/...
Fahimi, Saeedeh Oryan, Shahrbanoo Ahmadi, Ramesh Eidi, Akram
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Background Apoptosis is proposed as a possible mechanism for diabetes-induced hippocampal neuronal cell death. Numerous studies have suggested that the therapeutic properties of plants, such as antioxidant and anti-apoptotic, are effective in improving the complications of diabetes in the hippocampus. Objectives This study aimed to evaluate the ant...
