SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function i...
Published in Investigative Opthalmology & Visual Science
Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
...Published in Investigative Opthalmology & Visual Science
Purpose: Iron dysregulation can cause retinal disease, yet retinal iron regulatory mechanisms are incompletely understood. The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation of the iron transporter ferroportin (Fpn). Given that Hepc is expressed in the retina and Fpn is expressed in cells constitutin...
