Maiese, Kenneth
Published in
International review of neurobiology
Non-communicable diseases (NCDs) that involve neurodegenerative disorders and metabolic disease impact over 400 million individuals globally. Interestingly, metabolic disorders, such as diabetes mellitus, are significant risk factors for the development of neurodegenerative diseases. Given that current therapies for these NCDs address symptomatic c...
Nixon, Sara Jo Lewis, Ben
Published in
International review of neurobiology
Epidemiological estimates indicate not only an increase in the proportion of older adults, but also an increase in those who continue moderate alcohol consumption. Substantial literatures have attempted to characterize health benefits/risks of moderate drinking lifestyles. Not uncommonly, reports address outcomes in a single outcome, such as cardio...
Hoffman, Jessica L. Faccidomo, Sara Kim, Michelle Taylor, Seth M. Agoglia, Abigail E. May, Ashley M. Smith, Evan N. Wong, L.C. Hodge, Clyde W.
Published in
International review of neurobiology
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. Although the link between alcohol use and AD has been studied, preclinical research has potential to elucidate neurobiological mechanisms that underlie this interaction. This study was designed to test the hyp...
Vallée, M Mayo, W Koob, G F Le Moal, M
Published in
International review of neurobiology
The discovery that neurosteroids could be synthesized de novo in the brain independent from the periphery and display neuronal actions led to great enthusiasm for the study of their physiological role. Pharmacological studies suggest that neurosteroids may be involved in several physiological processes, such as learning and memory. This chapter sum...
Keyes, Katherine M. Allel, Kasim Staudinger, Ursula M. Ornstein, Katherine A. Calvo, Esteban
Published in
International review of neurobiology
Alcohol consumption is increasing in many countries, and excessive alcohol consumption is particularly increasing among older adults. Excessive alcohol consumption causes morbidity and mortality, especially among older adults, including an increased risk of depressive episodes. We review the mechanisms through which alcohol consumption may affect d...
Nunes, Polliana Toledo Kipp, Brian T. Reitz, Nicole L. Savage, Lisa M.
Published in
International review of neurobiology
Alcoholism is associated with brain damage and impaired cognitive functioning. The relative contributions of different etiological factors, such as alcohol, thiamine deficiency and age vulnerability, to the development of alcohol-related neuropathology and cognitive impairment are still poorly understood. One reason for this quandary is that both a...
Perkins, Amy E Varlinskaya, Elena I Deak, Terrence
Published in
International review of neurobiology
The passage of time dictates the pace at which humans and other organisms age but falls short of providing a complete portrait of how environmental, lifestyle and underlying biological processes contribute to senescence. Two fundamental features of the human experience that change dramatically across the lifespan include social interactions and, fo...
Kiyatkin, Eugene A Sharma, Hari Shanker
Published in
International review of neurobiology
Methamphetamine (METH) is a potent CNS stimulant that is widely used as a recreational drug. Due to its ability to increase bodily heat production and diminish heat loss due to peripheral vasoconstriction, METH is able to increase brain and body temperature. The hyperthermic effects of METH are potentiated when the drug is used under conditions of ...
Chandrasekaran, Krish Anjaneyulu, Muragundla Choi, Joungil Kumar, Pranith Salimian, Mohammad Ho, Cheng-Ying Russell, James W.
Published in
International review of neurobiology
Survival of human peripheral nervous system neurons and associated distal axons is highly dependent on energy. Diabetes invokes a maladaptation in glucose and lipid energy metabolism in adult sensory neurons, axons and Schwann cells. Mitochondrial (Mt) dysfunction has been implicated as an etiological factor in failure of energy homeostasis that re...
Höllerhage, Matthias
Published in
International review of neurobiology
In addition to neurodegenerative disorders, there are many secondary forms of parkinsonism. The most common cause for secondary parkinsonism is the intake of distinct drugs. Neuroleptics and calcium channel blockers have been mainly described to induce parkinsonism, but also other drugs were suspected to cause or worsen parkinsonism. Another common...
