Chen, Grace Q Kim, Won Nyeong Johnson, Kumiko Park, Mid-Eum Lee, Kyeong-Ryeol Kim, Hyun Uk
Published in
International journal of molecular sciences
Hydroxy fatty acids (HFAs) have numerous industrial applications but are absent in most vegetable oils. Physaria lindheimeri accumulating 85% HFA in its seed oil makes it a valuable resource for engineering oilseed crops for HFA production. To discover lipid genes involved in HFA synthesis in P. lindheimeri, transcripts from developing seeds at var...
Gnanavel, Mutharasu Murugesan, Akshaya Konda Mani, Saravanan Yli-Harja, Olli Kandhavelu, Meenakshisundaram
Published in
International journal of molecular sciences
Glioblastoma (GBM) is the most common malignant brain tumor and its malignant phenotypic characteristics are classified as grade IV tumors. Molecular interactions, such as protein-protein, protein-ncRNA, and protein-peptide interactions are crucial to transfer the signaling communications in cellular signaling pathways. Evidences suggest that signa...
Lee, Bohm Cho, Yongcheol
Published in
International journal of molecular sciences
Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon reg...
Ivanov, Marija Kannan, Abhilash Stojković, Dejan S Glamočlija, Jasmina Calhelha, Ricardo C Ferreira, Isabel C F R Sanglard, Dominique Soković, Marina
Published in
International journal of molecular sciences
Candidaalbicans represents one of the most common fungal pathogens. Due to its increasing incidence and the poor efficacy of available antifungals, finding novel antifungal molecules is of great importance. Camphor and eucalyptol are bioactive terpenoid plant constituents and their antifungal properties have been explored previously. In this study,...
Giudici, Ana Marcela Díaz-García, Clara Renart, Maria Lourdes Coutinho, Ana Prieto, Manuel González-Ros, José M Poveda, José Antonio
Published in
International journal of molecular sciences
Alkylammonium salts have been used extensively to study the structure and function of potassium channels. Here, we use the hydrophobic tetraoctylammonium (TOA+) to shed light on the structure of the inactivated state of KcsA, a tetrameric prokaryotic potassium channel that serves as a model to its homologous eukaryotic counterparts. By the combined...
Aleixandre-Carrera, Fernando Engelmayer, Nurit Ares-Suárez, David Acosta, María Del Carmen Belmonte, Carlos Gallar, Juana Meseguer, Víctor Binshtok, Alexander M
Published in
International journal of molecular sciences
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP ...
Fal, Kateryna Tomkova, Denisa Vachon, Gilles Chabouté, Marie-Edith Berr, Alexandre Carles, Cristel C
Published in
International journal of molecular sciences
An ongoing challenge in functional epigenomics is to develop tools for precise manipulation of epigenetic marks. These tools would allow moving from correlation-based to causal-based findings, a necessary step to reach conclusions on mechanistic principles. In this review, we describe and discuss the advantages and limits of tools and technologies ...
Szczepaniak, Jaroslaw Jagiello, Joanna Wierzbicki, Mateusz Nowak, Dorota Sobczyk-Guzenda, Anna Sosnowska, Malwina Jaworski, Slawomir Daniluk, Karolina Szmidt, Maciej Witkowska-Pilaszewicz, Olga
...
Published in
International journal of molecular sciences
The development of nanotechnology based on graphene and its derivatives has aroused great scientific interest because of their unusual properties. Graphene (GN) and its derivatives, such as reduced graphene oxide (rGO), exhibit antitumor effects on glioblastoma multiforme (GBM) cells in vitro. The antitumor activity of rGO with different contents o...
Yamaguchi, Masamitsu Omori, Kentaro Asada, Satoshi Yoshida, Hideki
Published in
International journal of molecular sciences
Amyotrophic lateral sclerosis (ALS) is the third most common neurodegenerative disorder and is sometimes associated with frontotemporal dementia. Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited peripheral neuropathies causing the slow progression of sensory and distal muscle defects. Of note, the severity and progression of ...
Deb, Subrata Chin, Mei Yieng Pham, Steven Adomat, Hans Hurtado-Coll, Antonio Gleave, Martin E Tomlinson Guns, Emma S
Published in
International journal of molecular sciences
The peripheral zone (PZ) and transition zone (TZ) represent about 70% of the human prostate gland with each zone having differential ability to develop prostate cancer. Androgens and their receptor are the primary driving cause of prostate cancer growth and eventually castration-resistant prostate cancer (CRPC). De novo steroidogenesis has been ide...
