Kim, Jong Min Park, Seon Kyeong Kang, Jin Yong Park, Su Bin Yoo, Seul Ki Han, Hye Ju Kim, Chul-Woo Lee, Uk Kim, Sea-Hyun Heo, Ho Jin
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Published in
International journal of molecular sciences
This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon (Diospyros kaki) (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. EFDK had high antioxidant activities and neuroprotective effects in HT22 cells....
Luger, Anna-Luisa Sauer, Benedikt Lorenz, Nadja I Engel, Anna L Braun, Yannick Voss, Martin Harter, Patrick N Steinbach, Joachim P Ronellenfitsch, Michael W
Published in
International journal of molecular sciences
Inducible gene expression is an important tool in molecular biology research to study protein function. Most frequently, the antibiotic doxycycline is used for regulation of so-called tetracycline (Tet)-inducible systems. In contrast to stable gene overexpression, these systems allow investigation of acute and reversible effects of cellular protein...
Carracedo, Julia Ramírez-Carracedo, Rafael Martínez de Toda, Irene Vida, Carmen Alique, Matilde De la Fuente, Mónica Ramírez-Chamond, Rafael
Published in
International journal of molecular sciences
Carbamylation is a post-translational modification of proteins that may partake in the oxidative stress-associated cell damage, and its increment has been recently proposed as a "hallmark of aging". The molecular mechanisms associated with aging are related to an increased release of free radicals. We have studied whether carbamylated proteins from...
Blanchard, Olivier Stepanovska, Bisera Starck, Manuel Erhardt, Martin Römer, Isolde Meyer Zu Heringdorf, Dagmar Pfeilschifter, Josef Zangemeister-Wittke, Uwe Huwiler, Andrea
Published in
International journal of molecular sciences
Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithelial cell line HK2, the profibrotic mediator transforming growth factor β (TGFβ) induces SK-1 mRNA an...
Tang, Hong-Yu Dong, Xu Wang, Jian-Ke Xia, Jun-Hui Xie, Fei Zhang, Yu Yao, Xuan Xu, Yue-Jin Wang, Zheng-Jie
Published in
International journal of molecular sciences
In this study, a single recessive gene (designated w₀) was identified to control the white immature fruit color. Genetic mapping with simple sequence repeats (SSR) markers located the w₀ gene in the distal region of cucumber chromosome 3 (Chr.3). Fine mapping was then conducted using the method of draft genome scaffold-assisted chromosome walking w...
Aouache, Rajaa Biquard, Louise Vaiman, Daniel Miralles, Francisco
Published in
International journal of molecular sciences
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even somet...
Matsumoto, Gen Matsumoto, Kazuki Kimura, Taeko Suhara, Tetsuya Higuchi, Makoto Sahara, Naruhiko Mori, Nozomu
Published in
International journal of molecular sciences
Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy. To understand the mechanisms underlying the cause of tauopathy, precise cellular and animal models are required. Recent data suggest that the transient introduction of ...
Krupa, Petr Vackova, Irena Ruzicka, Jiri Zaviskova, Kristyna Dubisova, Jana Koci, Zuzana Turnovcova, Karolina Urdzikova, Lucia Machova Kubinova, Sarka Rehak, Svatopluk
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Published in
International journal of molecular sciences
Human mesenchymal stem cells derived from Wharton's jelly (WJ-MSCs) were used for the treatment of the ischemic-compression model of spinal cord injury in rats. To assess the effectivity of the treatment, different dosages (0.5 or 1.5 million cells) and repeated applications were compared. Cells or saline were applied intrathecally by lumbar punctu...
Ceccarini, Maria Rachele Codini, Michela Conte, Carmela Patria, Federica Cataldi, Samuela Bertelli, Matteo Albi, Elisabetta Beccari, Tommaso
Published in
International journal of molecular sciences
Alpha-mannosidosis (α-mannosidosis) is a rare lysosomal storage disorder with an autosomal recessive inheritance caused by mutations in the gene encoding for the lysosomal α-d-mannosidase. So far, 155 variants from 191 patients have been identified and in part characterized at the biochemical level. Similarly to other lysosomal storage diseases, th...
Buha, Aleksandra Matovic, Vesna Antonijevic, Biljana Bulat, Zorica Curcic, Marijana Renieri, Elisavet A Tsatsakis, Aristidis M Schweitzer, Amie Wallace, David
Published in
International journal of molecular sciences
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and c...
