Hering, Larissa Katkeviciute, Egle Schwarzfischer, Marlene Niechcial, Anna Riggs, Julianne B Wawrzyniak, Marcin Atrott, Kirstin van de Sande, Marnix Lang, Silvia Becher, Burkhard
...
Published in
International journal of molecular sciences
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolled immune responses. The effect of DC-specific PTPN...
Feliksiak, Karolina Solarz, Daria Guzik, Maciej Zima, Aneta Rajfur, Zenon Witko, Tomasz
Published in
International journal of molecular sciences
Polylactide (PLA), widely used in bioengineering and medicine, gained popularity due to its biocompatibility and biodegradability. Natural origin and eco-friendly background encourage the search of novel materials with such features, such as polyhydroxyoctanoate (P(3HO)), a polyester of bacterial origin. Physicochemical features of both P(3HO) and ...
Miyagusuku-Cruzado, Gonzalo Voss, Danielle M Giusti, M Monica
Published in
International journal of molecular sciences
Pyranoanthocyanins are anthocyanin-derived pigments with higher stability to pH and storage. However, their slow formation and scarcity in nature hinder their industrial application. Pyranoanthocyanin formation can be accelerated by selecting anthocyanin substitutions, cofactor concentrations, and temperature. Limited information is available on th...
Miniou, Pierre Fontes, Michel
Published in
International journal of molecular sciences
Charcot-Marie-Tooth disease (CMT) is the most frequent hereditary peripheral neuropathies. It is subdivided in two main groups, demyelinating (CMT1) and axonal (CMT2). CMT1 forms are the most frequent. The goal of this review is to present published data on 1-cellular and animal models having opened new potential therapeutic approaches. 2-explorati...
De Fazio, Luigia Beghetti, Isadora Bertuccio, Salvatore Nicola Marsico, Concetta Martini, Silvia Masetti, Riccardo Pession, Andrea Corvaglia, Luigi Aceti, Arianna
Published in
International journal of molecular sciences
Necrotizing enterocolitis (NEC) is a gut inflammatory disorder which constitutes one of the leading causes of morbidity and mortality for preterm infants. The pathophysiology of NEC is yet to be fully understood; several observational studies have led to the identification of multiple factors involved in the pathophysiology of the disease, includin...
Jacques, Camille Floris, Ilaria Lejeune, Béatrice
Published in
International journal of molecular sciences
Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. H...
Bai, Yinshan Pan, Bo Zhan, Xiaoshu Silver, Hailey Li, Julang
Published in
International journal of molecular sciences
Forkhead box O3 (Foxo3) is a member of the FOXO subfamily within the forkhead box (FOX) family, which has been shown to be essential for ovarian follicular development and maturation. Previous studies have shown the abundant expression of miR-195-5p in the nuclei of porcine granulosa cells (GCs), suggesting its potential role during ovarian follicl...
Garbati, Patrizia Barbieri, Raffaella Calderoni, Matilde Baldini, Francesca Nizzari, Mario Modesto, Paola Florio, Tullio Pagano, Aldo
Published in
International journal of molecular sciences
High-risk neuroblastoma (HR-NB) still remains the most dangerous tumor in early childhood. For this reason, the identification of new therapeutic approaches is of fundamental importance. Recently, we combined the conventional pharmacological approach to NB, represented by cisplatin, with fendiline hydrochloride, an inhibitor of several transporters...
Harrison, Neale Koo, Chek Ziu Tomlinson, Michael G
Published in
International journal of molecular sciences
The ubiquitously expressed transmembrane protein a disintegrin and metalloproteinase 10 (ADAM10) functions as a "molecular scissor", by cleaving the extracellular regions from its membrane protein substrates in a process termed ectodomain shedding. ADAM10 is known to have over 100 substrates including Notch, amyloid precursor protein, cadherins, an...
Greco, Rosaria Demartini, Chiara Zanaboni, Anna Maria Tumelero, Elena Persico, Alessandra Candeloro, Elisa Morotti, Andrea Amantea, Diana Tassorelli, Cristina
Published in
International journal of molecular sciences
In ischemic stroke patients, a higher monocyte count is associated with disease severity and worse prognosis. The complex correlation between subset phenotypes and functions underscores the importance of clarifying the role of monocyte subpopulations. We examined the subtype-specific distribution of the CD163+ and CD80+ circulating monocytes and ev...
