Liu, Chenhui Jiang, Xunping Liu, Guiqiong Wassie, Teketay Girmay, Shishay
Published in
International journal of molecular sciences
The reproductive rhythm undergoes several changes during the evolution of mammals to adapt to local environmental changes. Although the critical roles of melatonin (MLT) in the formation of reproductive rhythm have been well established, the genetic basis for the changes of reproductive rhythm remains uncertain. Here, we constructed the phylogeneti...
Romswinkel, Alexander Infanger, Manfred Dietz, Carlo Strube, Florian Kraus, Armin
Published in
International journal of molecular sciences
We studied the behavior of Ewing's Sarcoma cells of the line A673 under simulated microgravity (s-µg). These cells express two prominent markers-the oncogene EWS/FLI1 and the chemokine receptor CXCR4, which is used as a target of treatment in several types of cancer. The cells were exposed to s-µg in a random-positioning machine (RPM) for 24 h in t...
Harada, Yoichiro Ohkawa, Yuki Kizuka, Yasuhiko Taniguchi, Naoyuki
Published in
International journal of molecular sciences
Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of the endoplasmic reticulum. This process, termed N-glycosylation, is a fundamental post-translational protein modification that is involved in the quality control, traffi...
Schröder, Annemarie Kriesen, Stephan Hildebrandt, Guido Manda, Katrin
Published in
International journal of molecular sciences
(1) Background: Emerging interest of physicians to use adipose-derived stem cells (ADSCs) for regenerative therapies and the fact that low-dose irradiation (LD-IR ≤ 0.1 Gy) has been reported to enhance the proliferation of several human normal and bone-marrow stem cells, but not that of tumor cells, lead to the idea of improving stem cell therapies...
Wang, Xuechun Chao, Nan Zhang, Meng Jiang, Xiangning Gai, Ying
Published in
International journal of molecular sciences
Caffeoyl shikimate esterase (CSE) has been reported to be involved in lignin biosynthesis; however, studies of CSE in gymnosperms are lacking. In this study, CSE was successfully cloned from Larix kaempferi (LkCSE) based on Larix laricina transcriptome screening. LkCSE was likely to have catalytic activity based on homologous sequence alignment and...
Idrees, Muhammad Xu, Lianguang El Sheikh, Marwa Sidrat, Tabinda Song, Seok-Hwan Joo, Myeong-Don Lee, Kyeong-Lim Kong, Il-Keun
Published in
International journal of molecular sciences
The PPARs (peroxisome proliferator-activated receptors) play critical roles in the regulation of lipid and glucose metabolism. PPARδ, a member of the PPARs family, is associated with decreased susceptibility to ectopic lipid deposition and is implicated in the regulation of mitochondrial processes. The current study aimed to determine the role of P...
Mieremet, Arnout Helder, Richard Nadaban, Andreea Gooris, Gert Boiten, Walter El Ghalbzouri, Abdoelwaheb Bouwstra, Joke A
Published in
International journal of molecular sciences
The outermost barrier layer of the skin is the stratum corneum (SC), which consists of corneocytes embedded in a lipid matrix. Biosynthesis of barrier lipids occurs de novo in the epidermis or is performed with externally derived lipids. Hence, in vitro developed human skin equivalents (HSEs) are developed with culture medium that is supplemented w...
Thorsen, Stine F Gromova, Irina Christensen, Ib J Fredriksson, Simon Andersen, Claus L Nielsen, Hans J Stenvang, Jan Moreira, José M A
Published in
International journal of molecular sciences
The burden of colorectal cancer (CRC) is considerable-approximately 1.8 million people are diagnosed each year with CRC and of these about half will succumb to the disease. In the case of CRC, there is strong evidence that an early diagnosis leads to a better prognosis, with metastatic CRC having a 5-year survival that is only slightly greater than...
Karbaschi, Mahsa Ji, Yunhee Abdulwahed, Abdulhadi Mohammed S Alohaly, Alhanoof Bedoya, Juan F Burke, Shanna L Boulos, Thomas M Tempest, Helen G Cooke, Marcus S
Published in
International journal of molecular sciences
Single cell gel electrophoresis, also known as the comet assay, has become a widespread DNA damage assessment tool due to its sensitivity, adaptability, low cost, ease of use, and reliability. Despite these benefits, this assay has shortcomings, such as long assay running time, the manipulation of multiple slides, individually, through numerous pro...
Williams, Kaye J Gieling, Roben G
Published in
International journal of molecular sciences
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment resistance and poor prognosis. The elucidation of the crystal structure of the catalytic domains o...
