Kemp Jacobsen, Katja O'Meara, Ellen S Key, Dustin S M Buist, Diana Kerlikowske, Karla Vejborg, Ilse Sprague, Brian L Lynge, Elsebeth von Euler-Chelpin, My
Published in
International journal of cancer. Journal international du cancer
Delivery of screening mammography differs substantially between the United States (US) and Denmark. We evaluated whether there are differences in screening sensitivity and specificity. We included screens from women screened at age 50-69 years during 1996-2008/2009 in the US Breast Cancer Surveillance Consortium (BCSC) (n = 2,872,791), and from two...
Hubaux, Roland Thu, Kelsie L Vucic, Emily A Pikor, Larissa A Kung, Sonia H Y Martinez, Victor D Mosslemi, Mitra Becker-Santos, Daiana D Gazdar, Adi F Lam, Stephen
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Published in
International journal of cancer. Journal international du cancer
Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none have explored their role in lung cancer. In this study, we identified MARK2 as frequently disrupted by DNA hypomethylation and copy gain, resulting in concordant overexpression in in...
Wallingford, Sarah C Iannacone, Michelle R Youlden, Danny R Baade, Peter D Ives, Alexander Verne, Julia Aitken, Joanne F Green, Adèle C
Published in
International journal of cancer. Journal international du cancer
White populations in Australia and England share many genetic and phenotypic characteristics due to common ancestry, but Australians experience far higher rates of melanoma due to higher ambient ultraviolet radiation (UVR) levels. To gain insight into the role of UVR on melanoma development early in life, we used national cancer registration data a...
Linabery, Amy M Erhardt, Erik B Richardson, Michaela R Ambinder, Richard F Friedman, Debra L Glaser, Sally L Monnereau, Alain Spector, Logan G Ross, Julie A Grufferman, Seymour
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Published in
International journal of cancer. Journal international du cancer
Family history of lymphoid neoplasm (LN) is a strong and consistently observed Hodgkin lymphoma (HL) risk factor, although it has been only marginally examined in pediatric/adolescent patients. Here, healthy control children identified by random digit dialing were matched on sex, race/ethnicity and age to HL cases diagnosed at 0-14 years at Childre...
Harris, Holly R Bergkvist, Leif Wolk, Alicja
Published in
International journal of cancer. Journal international du cancer
High endogenous hormone levels have been associated with breast cancer and dietary factors have the potential to influence breast cancer risk through effects on hormone levels. Dietary patterns derived from reduced rank regression provide a way to identify food groups correlated with hormones and subsequently examine food patterns that may be assoc...
Nordholm-Carstensen, Andreas Krarup, Peter-Martin Morton, Dion Harling, Henrik
Published in
International journal of cancer. Journal international du cancer
The causality between the metastatic potential, mismatch repair status (MMR) and survival in colorectal cancer (CRC) is complex. This study aimed to investigate the impact of MMR in CRC on the occurrence of synchronous metastases (SCCM) and survival in patients with SCCM on a national basis. A nationwide cohort study of 6,692 patients diagnosed wit...
Ehmsen, Sidse Hansen, Lea Tykgaard Bak, Martin Brasch-Andersen, Charlotte Ditzel, Henrik J Leth-Larsen, Rikke
Published in
International journal of cancer. Journal international du cancer
Triple-negative breast cancer (TNBC) represents a heterogeneous subgroup with generally poor outcome and lack of an effective targeted therapy. Prognostic or predictive biomarkers to guide treatment decisions for this group of patients are needed. To evaluate the potential of S100A14 protein as a novel biomarker in TNBC, the protein expression of S...
Schneider, Vanessa Zhang, Lu Rojewski, Markus Fekete, Natalie Schrezenmeier, Hubert Erle, Alexander Bullinger, Lars Hofmann, Susanne Götz, Marlies Döhner, Konstanze
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Published in
International journal of cancer. Journal international du cancer
Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens (LAA) represent immunogenic str...
Helgadottir, Hildur Höiom, Veronica Tuominen, Rainer Jönsson, Göran Månsson-Brahme, Eva Olsson, Håkan Hansson, Johan
Published in
International journal of cancer. Journal international du cancer
Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, index melanoma cases (n = 224) a...
Femia, Angelo Pietro Becherucci, Caterina Crucitta, Stefania Caderni, Giovanna
Published in
International journal of cancer. Journal international du cancer
Polyethylene glycol (PEG) is one of the most powerful agents in reducing chemically induced carcinogenesis in rat colon. However, contrasting results in Min mice dampened the enthusiasm on this potentially strong and virtually safe, cancer chemopreventing agent. Pirc (F344/NTac-Apc (am1137) ) rats carrying a germline heterozygous mutation in the Ap...
