Gautret, Philippe Lagier, Jean-Christophe Parola, Philippe Hoang, Van Thuan Meddeb, Line Mailhe, Morgane Doudier, Barbara Courjon, Johan Giordanengo, Valérie Vieira, Vera Esteves
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Published in
International journal of antimicrobial agents
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads. French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroq...
Barraud, Olivier Ravry, Céline François, Bruno Daix, Thomas Ploy, Marie-Cécile Vignon, Philippe
Published in
International journal of antimicrobial agents
In sepsis, early and appropriate antibiotic therapy is key but is frequently challenging due to the increasing incidence of multidrug-resistant bacteria. The feasibility of shotgun metagenomics (SM) has been scarcely assessed in urinary tract infections (UTIs). In this study, the feasibility of SM to detect both the microbiome and the resistome in ...
Milosevic, Tamara V Vertenoeil, Gaëlle Payen, Valéry L Sonveaux, Pierre Tulkens, Paul M Constantinescu, Stefan N Van Bambeke, Françoise
Published in
International journal of antimicrobial agents
Thrombocytopenia is commonly seen in patients receiving linezolid for >14 days. Linezolid is a reversible inhibitor of mitochondrial function in various cell types. This study investigated the inhibitory effects of linezolid and tedizolid, and their potential recovery on (i) CYTox I expression (subunit I of cytochrome c-oxidase; encoded by the mito...
Dinh, Aurélien Duran, Clara Pavese, Patricia Khatchatourian, Lydie Monnin, Boris Bleibtreu, Alexandre Denis, Eric Etienne, Cédric Rouanes, Nicolas Mahieu, Rafael
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Published in
International journal of antimicrobial agents
Dalbavancin is a glycopeptide antibiotic with a long half-life, recently marketed in Europe for skin and soft-tissue infections (SSTIs), but its real-life use is not well known. The aim of this study was to describe all first prescriptions in France over an 16-month period. A retrospective study on all adult patients receiving at least one dose of ...
Pani, Arianna Colombo, Fabrizio Agnelli, Francesca Frantellizzi, Viviana Baratta, Francesco Pastori, Daniele Scaglione, Francesco
Published in
International journal of antimicrobial agents
Ceftaroline fosamil is a fifth-generation cephalosporin with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity. It has been approved by the EMA and FDA for the treatment of adults and children with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI). However, ceftaroline fosam...
Longo, Luís G A de Sousa, Viviane S Kraychete, Gabriela B Justo-da-Silva, Lívia H Rocha, Jaqueline A Superti, Silvana V Bonelli, Raquel R Martins, Ianick S Moreira, Beatriz M
Published in
International journal of antimicrobial agents
Klebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for multi-drug-resistant bacteria, has been reported increasingly. Colistin-resistant K. pneumoniae (ColRKp) emerged in two hospitals in Rio de Janeiro stat...
Li, Guilian Xu, Zhengquan Jiang, Yi Liu, Haican Zhao, Li-Li Li, Machao Xu, Donglei Zhao, Xiuqin Liu, Zhiguang Wang, Ruibai
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Published in
International journal of antimicrobial agents
Clofazimine (CFZ) is a promising candidate drug for use in the management of multidrug-resistant tuberculosis (MDR-TB) patients. In this study, the minimum inhibitory concentration (MIC) method and checkerboard method were used to investigate potential synergies between CFZ and moxifloxacin (MOX) or capreomycin (CAP). Thirty Mycobacterium tuberculo...
Roy, Sandra M Riley, Margaret A
Published in
International journal of antimicrobial agents
The feasibility of using colicins to create an antimicrobial lubricant to prevent extraluminal catheter contamination during urinary catheter insertion was assessed. Levels of resistance of uropathogenic Escherichia coli to antibiotics and colicins were compared. The results showed that antibiotics and colicins possess similar frequencies of resist...
Berbel, Dàmaris Càmara, Jordi García, Ernesto Tubau, Fe Guérin, François Giard, Jean-Christophe Domínguez, M Ángeles Cattoir, Vincent Ardanuy, Carmen
Published in
International journal of antimicrobial agents
A lincosamide-resistant and macrolide-susceptible phenotype has not been described to date in Streptococcus pyogenes [group A streptococcus (GAS)]. The aim of this study was to characterize a GAS isolate susceptible to macrolides but resistant to lincosamide, streptogramin A and pleuromutilin antibiotics. Antimicrobial susceptibility was tested usi...
Nibbering, Peter H Göblyös, Anikó Adriaans, Alwin E Cordfunke, Robert A Ravensbergen, Bep Rietveld, Marion H Zwart, Sarah Commandeur, Suzan van Leeuwen, Remko Haisma, Elisabeth M
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Published in
International journal of antimicrobial agents
Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA) from human skin. To achieve this, the stability and antibacterial activity of the novel LL-37-deri...
