Shao, Ruonan Wang, Huizhong Wang, Jingzi Lu, Shujing He, Rongfang Lu, Yue
Published in
International immunopharmacology
Acutemyeloidleukaemia(AML) is an illness of varied origin and unpredictable prognosis. Pyroptosis, a novel class of gasdermin-mediated programmed cell death (PCD), serves a critical function in anti-leukemia. But, the correlation between pyroptosis-related genes (PRGs) and AML prognosis is undetermined. Here, we obtained the RNA profile and matched...
Li, Na Wang, Geng Hou, Xin Tai, Risheng Huang, Shaogang He, Zhize Lei, Lei Xu, Suling Yang, Shanru
Published in
International immunopharmacology
Immunotherapy is an emerging method for the treatment of cancer. Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune checkpoint pathways and release the body's anti-tumor immunity. They consist mainly of antibodies against cytotoxic T lymphocyte associated antigen-4 (CTLA-4), programmed death receptor 1 (PD-1), and progr...
Ding, Xianfei Tong, Ran Song, Heng Sun, Guiying Wang, Dong Liang, Huoyan Sun, Junyi Cui, Yuqing Zhang, Xiaojuan Liu, Shaohua
...
Published in
International immunopharmacology
Sepsis-related global mortality remains unacceptably high in intensive care units. Identifying the various molecular processes between survival and death in septic patients may assist in better treatment. Accurate prognostic evaluation of sepsis is an essentially unmet need. This study analyzed the metabolite changes in plasma between healthy contr...
Yaghoubi, Atieh Amel Jamehdar, Saeid Reza Akbari Eidgahi, Mohammad Ghazvini, Kiarash
Published in
International immunopharmacology
Ulcerative colitis (UC) is considered one of the most prevalent inflammatory bowel diseases (IBDs). However, due to the lack of satisfying efficacy of conventional therapies and their side effects, there is still a need for more efficient therapeutic agents. Melittin is a small peptide derived from bee venom, which shows potent anti-inflammatory ac...
Chen, Gege Chang, Yi Xiong, Yunzhao Hao, Juan Liu, Lingjin Liu, Ziqian Li, Hui Qiang, Panpan Han, Yutong Xian, Yunqian
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Published in
International immunopharmacology
Cardiorenal syndrome (CRS) is the leading cause of death associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, the underlying mechanisms of CRS are still poorly understood. Here, we studied a CKD model of unilateral ureteral obstruction (UUO) and observed pathological cardiac fibrosis and lymphangiogenesis in 180...
Ma, Xiancheng Sun, Yunxiao Wang, Dahai Lin, Yi Chang, Hong
Published in
International immunopharmacology
IgA vasculitis is characterized by inflammation of the blood vessels, which can result in microvascular destruction and consequently renal damage. Transthyretin is a newly discovered angiogenesis regulator in promoting microvascular regeneration. This indicates that transthyretin may act as a potential predictor of IgAV as well as IgAVN. This retro...
Liu, Yuanyuan Chen, Shuyu Yu, Li Deng, Yao Li, Difei Yu, Xiu Chen, Dandan Lu, Ye Liu, Shengming Chen, Rongchang
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Published in
International immunopharmacology
Idiopathic pulmonary fibrosis is a chronic progressive disease associated with substantial morbidity and mortality despite advances in medical therapy. Increasing evidence suggests that peroxisome proliferator-activated receptors (PPARs) play important roles in the fibrosis-related diseases and their agonists may become effective therapeutic target...
Duarte, Hugo S Veiga, Cassia R P Veiga, Claudimar P Wainstein, Alberto J A Drummond-Lage, Ana P
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International immunopharmacology
Immunotherapy revolutionized cancer care in the last decade and, notably among its tools, the programmed cell death protein-1 (PD-1) inhibitors. These drugs are related to increased life expectancy rates. However, they can cause several adverse events that have not been fully characterized, thus challenging clinical practice. To evaluate the toxici...
Chen, Beilei Cao, Pingping Guo, Xin Yin, Mengmei Li, Xiaobo Jiang, Li Shao, Jun Chen, Xin Jiang, Chao Tao, Luhang
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Published in
International immunopharmacology
Neuroinflammation is a key factor that contributes to the secondary damage after cerebral ischemia/reperfusion (CI/R) injury. Chemokine receptor type 5 (CCR5) has shown its pro-inflammatory effects during central nervous system (CNS) diseases. However, the role of CCR5 in CI/R injury is still unclear. In this study, we administered maraviroc (MVC, ...
Yang, Shu-Ping Su, Qing Zhang, Ya-Ru Sun, Yun Chai, Yu-Rong
Published in
International immunopharmacology
As the main lymphoid organ, the thymus degenerates with age. The loss of thymic epithelial cells is mainly related to thymus degeneration and reduced T cells development. As an insulin sensitizer, metformin is a first-line drug for the treatment of diabetes and has been shown to prolong the lifespan of mice, but the mechanism is still unclear. In t...
