Zhang, Qiulei Le, Kehao Xu, Ming Zhou, Jun Xiao, Yunxiao Yang, Wen Jiang, Yujia Xi, Zihan Huang, Tao
Published in
International immunopharmacology
Tumor-associated macrophages (TAMs) are closely related to poor prognosis in triple-negative breast cancer (TNBC). Thus, gaining insight into how TAMs support cancer progression could contribute to effective therapies. We utilized the 4 T1 murine TNBC cell line and murine bone marrow-derived macrophages to assess TAM-mediated pro-proliferative effe...
Wang, Jingnan Li, Ruiru Lin, Haobo Qiu, Qian Lao, Minxi Zeng, Shan Wang, Cuicui Xu, Siqi Zou, Yaoyao Shi, Maohua
...
Published in
International immunopharmacology
The accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the roles of cytosolic dsDNA in the modulation of inflammatory responses of fibroblast-like synoviocy...
Wu, Jianqi Cui, Yulin Zhu, Wenwen Bai, Song Zhao, Na Liu, Beixing
Published in
International immunopharmacology
CD4+T cells are crucial cellular source of type 2 cytokines and responsible for RSV-induced asthma-like symptoms and asthma exacerbations. However, the mechanism for regulating the activation of CD4+T cells during RSV infection is not clear completely. We show in this study that infection with RSV may induce an expansion and activation of CD4+T cel...
Li, Chunxiao Wei, Shuhua Xu, Xiaofei Jiang, Yuliang Xue, Lixiang Jiang, Ping Wang, Junjie
Published in
International immunopharmacology
Sorafenib has been systemically utilized to therapy the advanced hepatocellular carcinoma (HCC). Natural killer cells (NKs) are important cytotoxic innate lymphocytes, which can exert effector functions especially in liver and tumor. However, how Sorafenib affects the function of NKs remains to be elucidated. Here, we utilized the subcutaneous and ...
Zhang, Xuan Chen, Yi-Ran Zhao, Ye-Li Liu, Wei-Wei Hayashi, Toshihiko Mizuno, Kazunori Hattori, Shunji Fujisaki, Hitomi Ogura, Takayuki Onodera, Satoshi
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Published in
International immunopharmacology
Extracellular matrix (ECM) comprising the environments of multicellular society has a dynamic network structure. Collagen is one of the ubiquitous components of ECM. Collagen affects the inflammatory response by regulating the release of pro-inflammatory cytokines from cells. Gelatin, denatured collagen found temporally in tissues, is supposed to b...
Heidary, Fatemeh Ardestani, Sussan K Ghasemi, Hassan Javadi, Mohammad Ali Mahmoudi, Mahmoud Yaraee, Roya Shams, Jalaledin Falahi, Faramarz Sedighi Moghadam, Mohamad Reza Shariatpanahi, Shamsa
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Published in
International immunopharmacology
In this study, the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), P-, E-, and L-selectins were investigated in seriously eye-injured patients exposed to sulfur mustard (SM). A total of 128 individuals with SM-induced serious eye injuries and 31 healthy male controls were included in this study. The serum concentration of solubl...
Luo, Xu Lin, Bo Gao, Youguang Lei, Xianghui Wang, Xiang Li, Yunfeng Li, Tao
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International immunopharmacology
The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In the present study, we aimed to...
Mortezaee, Keywan Parwaie, Wrya Motevaseli, Elahe Mirtavoos-Mahyari, Hanifeh Musa, Ahmed Eleojo Shabeeb, Dheyauldeen Esmaely, Farid Najafi, Masoud Farhood, Bagher
Published in
International immunopharmacology
Radiotherapy is one of the most common treatment modalities for controlling a wide range of tumors. However, it has been shown that radiotherapy alone is unable to completely eradicate some tumors and could be associated with a high possibility of tumor recurrence. To date, various experimental and clinical studies have been conducted to explore so...
Fei, Xiaowei Chen, Chen Kai, Sun Fu, Xiaojun Man, Weitao Ding, Boyun Wang, Chongwu Xu, Ruxiang
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International immunopharmacology
Intracranial hemorrhage (ICH) is one of the most common brain traumas, and inflammation caused by ICH seriously affects the quality of life and prognosis of patients. Eupatilin has been shown to have anti-inflammatory effects in various diseases. However, only one paper has reported that Eupatilin has a therapeutic effect on the inflammatory respon...
Qin, Hui-Di Shi, Yan-Qiu Liu, Zhao-Hua Li, Zhong-Gang Wang, Huai-Shan Wang, Hong Liu, Zhao-Ping
Published in
International immunopharmacology
