Yu, Ming Yun Jia, Hui Jie Zhang, Jing Ran, Guang He Liu, Yan Yang, Xiu Hong
Published in
International immunopharmacology
Macrophages are highly heterogeneous and plastic immune cells that play an important role in the fight against pathogenic microorganisms and tumor cells. After different stimuli, macrophages can polarize to the M1 phenotype to show a pro-inflammatory effect and the M2 phenotype to show an anti-inflammatory effect. The balance of macrophage polariza...
Gomaa, Adel A Farghaly, Hanan S M Ahmed, Asmaa M Hemida, Fahmy K
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International immunopharmacology
Apremilast (Apre), a novel phosphodiesterase-4 (PDE4) inhibitor, has been shown to have anti-inflammatory, immunomodulator, neuroprotective and senolytic properties, therefore, Apre like other PDE4 inhibitors may be a promising candidate for treatment of Alzheimer's disease (AD). To evaluate the effectiveness of Apre on Alzheimer's like pathology a...
Cole, Kathryn Al-Kadhimi, Zaid Talmadge, James E
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International immunopharmacology
Immunotherapy is an additional pillar when combined with traditional standards of care such as chemotherapy, radiotherapy, and surgery for cancer patients. It has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapies, including adoptive cellular therapy (ACT) and checkpoint inhibitors (CPIs)...
Tegenge, Million A Mahmood, Iftekhar Struble, Evi B Sauna, Zuben
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International immunopharmacology
In Part 1, we provided a general description of macromolecules, pharmacokinetics (PK) characteristics in non-pregnant subjects, and the physiological changes during pregnancy. Here we further elaborate on the impact of pregnancy on the PK of antibodies through illustrative case studies (immunoglobulins, infliximab, adalimumab and eculizumab). Using...
Xiong, Yue Chen, Jianhui Lv, Mingqi Wang, Feifei Zhang, Hanhong Tang, Boyi Li, Yingbo
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International immunopharmacology
Inflammation plays an essential role in the pathogenesis of autism spectrum disorder (ASD). Thymol is a bioactive monoterpene isolated from Thymus vulgaris that has anti-inflammatory properties and is helpful in neurodevelopmental disorders. The purpose of this study was to investigate the effects of thymol on autism-like behaviours in rats with VP...
Afrooghe, Arya Babaei, Mohammadreza Shayan, Maryam Ahmadi, Elham Mohammad Jafari, Razieh Dehpour, Ahmad-Reza
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International immunopharmacology
Itching is an unpleasant sensation on the skin that could negatively impact the quality of life. Over the years, many non-pharmacological and pharmacological approaches have been introduced to mitigate this burdensome condition; However, the effectiveness of these methods remains questioned. Bromhexine, derived from the Adhatoda vasica plant, is a ...
Yu, Jingfeng Sheng, Sihan Zou, Xiaosu Shen, Zhengwu
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International immunopharmacology
A novel artemisinin derivative, dihydroartemisinin-ursodeoxycholic acid conjugate (4), was found to exhibit strong immunosuppressive activity. Various methods were used to evaluate the immunosuppressive activity and mechanism of action of the compound to explore its potential applications. T cell proliferation, mixed lymphocyte reaction (MLR), and ...
Wang, Xianshi Zhou, Liya Ye, Shasha Liu, Sidan Chen, Lin Cheng, Zizhao Huang, Yuli Wang, Beibei Pan, Minling Wang, Dezhong
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International immunopharmacology
Acute lung injury (ALI) is a serious and common clinical disease. Despite significant progress in ALI treatment, the morbidity and mortality rates remain high. However, no effective drug has been discovered for ALI. FGF4, a member of the FGF family, plays an important role in the regulation of various physiological and pathological processes. There...
Rancan, F Rajes, K Sidiropoulou, P Hadam, S Guo, X Zabihi, F Mirastschijski, U Rühl, E Haag, R Blume-Peytavi, U
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International immunopharmacology
Rapamycin, also known as Sirolimus, is a promising anti-proliferative drug, but its therapeutic use for the topical treatment of inflammatory, hyperproliferative skin disorders is limited by insufficient penetration rates due to its high molecular weight (MW of 914.172 g/mol) and high lipophilicity. We have shown that core multi-shell (CMS) nanocar...
Tong, Mingwei Yang, Xiaodan Liu, Haixia Ge, Huihui Huang, Guangrong Kang, Xing Yang, Hao Liu, Qingqing Ren, Peng Kuang, Xiaoyu
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International immunopharmacology
Obesity, an increasingly prevalent disease worldwide, is accompanied by chronic inflammation and intestinal dysbiosis. Helminth infections have been increasingly proved to exhibit a protective role in several inflammation-associated diseases. Considering the side effects of live parasite therapy, efforts have been made to develop helminth-derived a...