Chen, Siyin Zhang, Jing Shen, Meiying Han, Xiaojian Li, Shenglong Hu, Chao Wang, Wang Li, Luo Du, Li Pang, Da
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Published in
International immunopharmacology
The efficacy of adoptive cell therapy (ACT) relies on the abilities of T cells in self-expansion, survival and the secretion of effector molecules. Here, we presented an optimized method to generate T cells with improved functions by supplementing the culture medium with p38 inhibitor and the combination of IL-7 and IL-15 or IL-2 alone. The additio...
Rajasekar, Nandhine Sivanantham, Ayyanar Kar, Amrita Mukhopadhyay, Sramana Mahapatra, Santanu Kar Paramasivam, Sudhakar Gandhi Rajasekaran, Subbiah
Published in
International immunopharmacology
Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbum...
Radbakhsh, Shabnam Atkin, Stephen L Simental-Mendia, Luis E Sahebkar, Amirhossein
Published in
International immunopharmacology
Incretin hormones, including glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP), are gastrointestinal peptides secreted from enteroendocrine cells. These hormones play significant roles in many physiological processes via binding to G-protein coupled receptors (GPCRs) on different organs and tissues; one of ...
Jin, Zheng Zhu, Zhenhua
Published in
International immunopharmacology
Pattern recognition receptors (PRRs) are a kind of recognition molecules mainly expressed on innate immune cells. PRRs recognize one or more kinds of pathogen-associated molecular patterns (PAMPs), inducing the production of interleukin (IL), tumor necrosis factor (TNF), interferon (IFN) and other related cytokines to aggravate immune-related disea...
Bian, Liang Chen, Huaguo Zhou, Xin
Published in
International immunopharmacology
Mori Fructus (MF) is a traditional Chinese medicine with long application history, which has protective effects on liver diseases. Mori Fructus polysaccharide (MFP) is one of the active ingredients of MF and possesses therapeutic effects against acute alcoholic liver injury. Recent researches have reported that the therapeutic effects of MFP might ...
Cheng, Mengfei Zhang, Shuo Liu, Jiahui Jiang, Shuai Dong, Mei
Published in
International immunopharmacology
Immune checkpoint inhibitors (ICIs) have been demonstrated an effective treatment in multiple tumor type, which restore the immune response to against cancer cell. Currently, approved ICIs include anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4); anti-programmed cell death 1 (PD-1) and anti-programmed cell death ligand 1 (PD-L1) monoclonal antibodies...
England, Bryant R Campany, Megan Sayles, Harlan Roul, Punyasha Yang, Yangyuna Ganti, Apar Kishor Sokolove, Jeremy Robinson, William H Reimold, Andreas M Kerr, Gail S
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Published in
International immunopharmacology
We aimed to assess whether serum cytokine/chemokine concentrations predict incident cancer in RA patients. Data from cancer-free enrollees in the Veterans Affairs Rheumatoid Arthritis (VARA) Registry were linked to a national VA oncology database and the National Death Index (NDI) to identify incident cancers. Seventeen serum cytokines/chemokines w...
Yang, Qing Zhao, Zhen-Zhen Xie, Jian Wang, Yun-Peng Yang, Kai Guo, Yu Wang, Jia-Feng Deng, Xiao-Ming
Published in
International immunopharmacology
Senkyunolide I (SEI)exerts considerable protective effects in various disease models, but its effect on hepatic ischemia-reperfusion (I/R) injury remains unknown. This research aimed to investigate the effect of SEI in a murine model of hepatic I/R injury. With modified liver I/R murine model, low, medium and high doses of SEI were injected intrape...
Lv, Qi Xing, Yao Dong, Dong Hu, Yang Chen, Qingzhu Zhai, Linhui Hu, Lihong Zhang, Yinan
Published in
International immunopharmacology
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. Costunolide, the main active constituent of Radix Aucklandiae, has been demonstrated to possess anti-inflammatory and immunomodulation activities. The aim of this study is to investigate the effect of costunolide on UC induced by dextran sulfate sodium (DSS). Results sh...
Banerjee, Abhirup Ray, Surajit Vorselaars, Bart Kitson, Joanne Mamalakis, Michail Weeks, Simonne Baker, Mark Mackenzie, Louise S
Published in
International immunopharmacology
Since December 2019 the novel coronavirus SARS-CoV-2 has been identified as the cause of the pandemic COVID-19. Early symptoms overlap with other common conditions such as common cold and Influenza, making early screening and diagnosis are crucial goals for health practitioners. The aim of the study was to use machine learning (ML), an artificial n...
