Rubel, Kolin E Lopez, Andrea Lubner, Rory J Lee, Diane L Yancey, Kristen Chandra, Rakesh K Chowdhury, Naweed I Turner, Justin H
Published in
International forum of allergy & rhinology
The modified five-item frailty index (mFI-5) is a validated risk stratification tool with the ability to predict adverse outcomes following surgery. In this study, we sought to use mFI-5 to assess the potential relationship between unhealthy aging and postoperative endoscopic sinus surgery (ESS) outcomes. Patients who underwent sinus surgery at Van...
Meltzer, Eli O Mullol, Joaquim Ko, Jinnie Saenz, Rebecca Steinke, John W Millette, Lauren A Gevaert, Philippe
Published in
International forum of allergy & rhinology
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have high incidence of sleep impairment. We evaluated the impact of omalizumab treatment on sleep characteristics and associated health status in patients with CRSwNP. Prespecified exploratory analysis assessed outcomes from patients included in the POLYP 1 and POLYP 2 phase 3 clinical...
Lee, Robert J Adappa, Nithin D Palmer, James N
Published in
International forum of allergy & rhinology
The role of Akt in nasal immunity is unstudied. Akt phosphorylates and activates endothelial nitric oxide synthase (eNOS) expressed in epithelial ciliated cells. Nitric oxide (NO) production by ciliated cells can have antibacterial and antiviral effects. Increasing nasal NO may be a useful antipathogen strategy in chronic rhinosinusitis (CRS). We p...
Miller, Jessa E Taylor-Cousar, Jennifer L Overdevest, Jonathan B Khatiwada, Aastha Mace, Jess C Alt, Jeremiah A Bodner, Todd E Chowdhury, Naweed I DiMango, Emily A Eshaghian, Patricia H
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Published in
International forum of allergy & rhinology
Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF). The Questionnaire of Olfactory Disorders (QOD) is a validated instrument that evaluates olfactory-specific quality-of-life. The QOD minimal clinically important difference (MCID) and factors associated with olfactory improvement after elexacaftor/tezacaftor/ivacaftor hav...
Wu, Arthur W Tang, Dennis M Hur, Kevin Jafari, Aria Chen, Philip G Takashima, Masayoshi Chang, Elena E Balzer, Bonnie Mathew, Anna Divatia, Mukul
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Published in
International forum of allergy & rhinology
Hispanic-American patients with chronic rhinosinusitis with nasal polyps have a comparable level of tissue eosinophilia compared to their Caucasian counterparts in the United States. Mixed inflammation involving both neutrophils and eosinophils is more common in this population compared to Caucasians. Findings from this study may indicate that Hisp...
Kim, Yeo E Wang, Andrea Christos, Paul J Valente, Katherine E Reisacher, William R
Published in
International forum of allergy & rhinology
This is the first study to quantify the accuracy, sensitivity, and specificity of the human olfactory system in detecting peanuts in common food items. With more competing sensory input, the human olfactory sensitivity to peanuts decreases; this is especially evident when peanuts are mixed in sauces. Metrics established in this study can be used to...
Sutton, Sarah R Taniguchi, April N Nguyen, Shaun A Soler, Zachary M Schlosser, Rodney J
Published in
International forum of allergy & rhinology
The pandemic caused an increase in computed tomography imaging in patients with sinusitis, which persisted post-COVID. Nasal endoscopies significantly decreased during COVID but returned to pre-COVID levels in 2022. The management of cerebrospinal fluid leaks, tumors, and orbital pathology was not impacted by the pandemic. © 2023 ARS-AAOA, LLC.
Pipaliya, Royal M Duckett, Kelsey A Monaghan, Neil P Miller, Emma Marin Young, Gabrielle Brennan, Emily A Nguyen, Shaun A Soler, Zachary M Schlosser, Rodney J
Published in
International forum of allergy & rhinology
The placebo effect observed in clinical trials evaluating medical treatments for chronic rhinosinusitis (CRS) is not well understood. This systematic review and meta-analysis sought to characterize the placebo effect present within CRS outcomes. A systematic review of PubMed, Scopus, and Cumulated Index in Nursing and Allied Health Nursing (CINAHL)...
Munyemana, Marie-Ange Ahmed, Omar G Takashima, Mas Dhanda, Aatin K Tang, Dennis Wu, Arthur Wu, Matthew J Kallogjeri, Dorina Piccirillo, Jay F Roland, Lauren T
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Published in
International forum of allergy & rhinology
Acute invasive fungal sinusitis (IFS) is a rare disease with high mortality There is no designated International Classification of Diseases code for IFS We propose a novel method to identify IFS using optimized codes complemented by medications. © 2023 ARS-AAOA, LLC.
Bachert, Claus Khan, Asif H Lee, Stella E Hopkins, Claire Peters, Anju T Fokkens, Wytske Praestgaard, Amy Radwan, Amr Nash, Scott Jacob-Nara, Juby A
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Published in
International forum of allergy & rhinology
This post hoc analysis of the international SINUS-24/-52 trials (NCT02912468/NCT02898454) aimed to assess dupilumab efficacy in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) according to different definitions of type 2 inflammatory signature. Six definitions of type 2 inflammation were used: ≥150 eosinophils/μL or total imm...
