Zhao, Irene Shuping Yin, Iris Xiaoxue Mei, May Lei Lo, Edward Chin Man Tang, Jinyao Li, Quanli So, Lok Yan Chu, Chun Hung
Published in
International Journal of Nanomedicine
Objective To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries. Materials and Methods Demineralized human dentine blocks were allocated to three groups. The blocks in group 1 underwent a topical application of a 12% silv...
Grafals-Ruiz, Nilmary Rios-Vicil, Christian I Lozada-Delgado, Eunice L Quiñones-Díaz, Blanca I Noriega-Rivera, Ricardo A Martínez-Zayas, Gabriel Santana-Rivera, Yasmarie Santiago-Sánchez, Ginette S Valiyeva, Fatma Vivas-Mejía, Pablo E
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Published in
International Journal of Nanomedicine
Introduction Glioblastoma (GBM) is the most common and lethal of the central nervous system (CNS) malignancies. The initiation, progression, and infiltration ability of GBMs are attributed in part to the dysregulation of microRNAs (miRNAs). Thus, targeting dysregulated miRNAs with RNA oligonucleotides (RNA interference, RNAi) has been proposed for ...
Zhang, Keda Yu, Li Li, Fu-Rong Li, Xue Wang, Zhefeng Zou, Xiaoting Zhang, Chi Lv, Kongpeng Zhou, Boping Mitragotri, Samir
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Published in
International Journal of Nanomedicine
Purpose The topical application of exosomes secreted by mesenchymal stem cells (MSC-Exos) on the skin is a very new and interesting topic in the medical field. In this study, we aimed to investigate whether marine sponge Haliclona sp. spicules (SHSs) could effectively enhance the skin delivery of human umbilical cord-derived MSC-Exos (hucMSC-Exos),...
Wu, Pingping Zhu, Huayun Zhuang, Yan Sun, Xiaofeng Gu, Ning
Published in
International Journal of Nanomedicine
Background Owing to its combined effects, the co-delivery of different therapeutics is a promising option for the treatment of cancer. In the present study, tumor-targeting poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) nanoparticles were developed for the transportation of two molecules, namely chemotherapeutic drug 5-fluorouracil (5Fu) and rad...
Liu, Yi Zhao, Jingtong Jiang, Jinlan Chen, Fangfang Fang, Xuedong
Published in
International Journal of Nanomedicine
Purpose The primary goal of the present study was to design doxorubicin (DOX)-loaded superparamagnetic iron oxide (SPIO) nanoparticles (NPs) coated with mesenchymal stem cell (MSC) membranes and explore their effect on colon cancer in vitro and in vivo. Methods DOX-SPIO NPs were coated with MSC membranes using an extruder, and the morphological cha...
Fana, Michael Gallien, John Srinageshwar, Bhairavi Dunbar, Gary L Rossignol, Julien
Published in
International Journal of Nanomedicine
Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to current treatment options. Despite major advancements in the fields of surgery and chemoradiotherapy over the last few decades, the life expectancy for someone with glioblastoma remains virtually unchanged and warrants a new approach for treatment. Poly(amid...
Hu, Qing Wang, Yifei Xu, Lu Chen, Dawei Cheng, Lifang
Published in
International Journal of Nanomedicine
Introduction A multifunctional redox- and pH-responsive polymeric drug delivery system is designed and investigated for targeted anticancer drug delivery to liver cancer. Methods The nanocarrier (His-PAMAM-ss-PEG-Tf, HP-ss-PEG-Tf) is constructed based on generation 4 polyamidoamine dendrimer (G4 PAMAM). Optimized amount of histidine (His) residues ...
Tao, Ran Wang, Chengzhang Lu, Yin Zhang, Changwei Zhou, Hao Chen, Hongxia Li, WenJun
Published in
International Journal of Nanomedicine
Background This study demonstrated an innovative formulation including the polyprenol (GBP) lipid and vitamin E-TPGS hybrid nanoparticles (NPs) which was aimed to control the transfer of betulinic acid (BA) and low-substituted hydroxyl fullerenol (C60(OH)n). Additionally, it developed BA-C60(OH)n-GBP-TPGS-NPs delivery system and researched the anti...
Liu, Yupeng Dai, Suhuan Wen, Lijuan Zhu, Yun Tan, Yanan Qiu, Guoxi Meng, Tingting Yu, Fangying Yuan, Hong Hu, Fuqiang
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Published in
International Journal of Nanomedicine
Background Phototherapy is a potential new candidate for glioblastoma (GBM) treatment. However inadequate phototherapy due to stability of the photosensitizer and low target specificity induces the proliferation of neovascular endothelial cells for angiogenesis and causes poor prognosis. Methods In this study, we constructed c(RGDfk)-modified glyco...
Loutfy, Samah A Elberry, Mostafa H Farroh, Khaled Yehia Mohamed, Hossam Taha Mohamed, Aya A Mohamed, ElChaimaa B Faraag, Ahmed Hassan Ibrahim Mousa, Shaker A
Published in
International Journal of Nanomedicine
Purpose Current direct-acting antiviral agents for treatment of hepatitis C virus genotype 4a (HCV-4a) have been reported to cause adverse effects, and therefore less toxic antivirals are needed. This study investigated the role of curcumin chitosan (CuCs) nanocomposite as a potential anti-HCV-4a agent in human hepatoma cells Huh7. Methods Docking ...
