Huang, Moran Ye, Kai Hu, Tu Liu, Kexin You, Mengzhen Wang, Lei Qin, Hui
Published in
International Journal of Nanomedicine
Purpose Despite the extensive development of antibacterial biomaterials, there are few reports on the effects of materials on the antibacterial ability of the immune system, and in particular of neutrophils. In this study, we observe differences between the in vivo and in vitro anti-infective efficacies of silver nanoparticles (AgNPs). The present ...
Zhang, Yanan Chen, Xiajing Liu, Lingjuan Tian, Jie Hao, Lan Ran, Hai-tao
Published in
International Journal of Nanomedicine
Background and Purpose Myocardial infarction (MI) is a serious threat to public health. The early identification of MI is important to promote appropriate treatment strategies for patients. Recently, strategies targeting extracellular matrix (ECM) components have gained attention. Fibrin is an ECM protein involved after MI. In this work, we constru...
Goo, Yoon Tae Sa, Cheol-Ki Choi, Ji Yeh Kim, Min Song Kim, Chang Hyun Kim, Hyeon Kyun Choi, Young Wook
Published in
International Journal of Nanomedicine
Purpose To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed. Methods Surfactants and solid carriers were screened based on a solubility and a flowability test, respectively. Supersaturating agents, including Poloxamer 407 (P407), were screened. The SSuM was optimized using a Box-Behnke...
Li, Chen Wan, Long Luo, Jie Jiang, Mingyan Wang, Keke
Published in
International Journal of Nanomedicine
Diabetes mellitus is a major threat to human health. Both its incidence and prevalence have been rising steadily over the past few decades. Biomacromolecular agents such as insulin and glucagon-like peptide 1 receptor agonists are commonly used hypoglycemic drugs that play important roles in the treatment of diabetes. However, their traditional fre...
Edis, Zehra Wang, Junli Waqas, Muhammad Khurram Ijaz, Muhammad Ijaz, Munazza
Published in
International Journal of Nanomedicine
Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for s...
Gurunathan, Sangiliyandi Kang, Min-Hee Kim, Jin-Hoi
Published in
International Journal of Nanomedicine
Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the extracellular environment upon fusion of multivesicular bodies and plasma membrane. Biogenesis of exosomes is a protein quality control mechanism, and once released, exosomes transmit signals to other cells. The applications of exosomes have increased immensel...
Dou, Jun Li, Luoyang Guo, Mei Mei, Feng Zheng, Danfeng Xu, Hui Xue, Rui Bao, Xueyang Zhao, Fengshu Zhang, Yu
...
Published in
International Journal of Nanomedicine
Background and Aim Acute myeloid leukemia (AML), initiated and maintained by leukemia stem cells (LSCs), is often relapsed or refractory to therapy. The present study aimed at assessing the effects of nanozyme-like Fe3O4 nanoparticles (IONPs) combined with cytosine arabinoside (Ara-C) on LSCs in vitro and in vivo. Methods The CD34+CD38–LSCs, isolat...
Irfan, Malik Muhammad Shah, Shefaat Ullah Khan, Ikram Ullah Munir, Muhammad Usman Khan, Nauman Rahim Shah, Kifayat Ullah Rehman, Saif Ur Sohaib, Muhammad Basit, Hafiz Muhammad Mahmood, Saima
...
Published in
International Journal of Nanomedicine
Introduction The current work aimed to formulate a novel chitosan-based finasteride nanosystem (FNS-NS) for skin delivery to optimize the drug availability in skin for a longer time and enhance ex vivo performance of finasteride against androgenic alopecia. Methods Both undecorated and chitosan decorated FNS-NSs were synthesized by a high energy em...
Xu, Hongfei Ji, Hongyu Li, Zerong Qiao, Wenmei Wang, Chenghao Tang, Jingling
Published in
International Journal of Nanomedicine
Background Pulmonary arterial hypertension (PAH) is characterized by abnormal proliferation of vascular endothelial and smooth muscle cells and causes occlusion of pulmonary arterioles that eventually results in right heart failure and death. The platelet-derived growth factor (PDGF) plays a prominent role in abnormal remodeling of pulmonary resist...
Kittana, Naim Assali, Mohyeddin Zimmermann, Wolfram-Hubertus Liaw, Norman Santos, Gabriela Leao Rehman, Abdul Lutz, Susanne
Published in
International Journal of Nanomedicine
Background Under certain conditions, the physiological repair of connective tissues might fail to restore the original structure and function. Optimized engineered connective tissues (ECTs) with biophysical properties adapted to the target tissue could be used as a substitution therapy. This study aimed to investigate the effect of ECT enforcement ...
