Falgàs, Aïda Pallarès, Victor Unzueta, Ugutz Núñez, Yáiza Sierra, Jorge Gallardo, Alberto Alba-Castellón, Lorena Mangues, Maria Antonia Álamo, Patricia Villaverde, Antonio
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Published in
International Journal of Nanomedicine
Background and Purpose Around 40–50% of diffuse large-B cell lymphoma (DLBCL) patients suffer from refractory disease or relapse after R-CHOP first-line treatment. Many ongoing clinical trials for DLBCL patients involve microtubule targeting agents (MTAs), however, their anticancer activity is limited by severe side effects. Therefore, we chose to ...
Si, Yiran Yue, Jian Liu, Zhaoyang Li, Mo Du, Feng Wang, Xue Dai, Zhong Hu, Nanlin Ju, Jie Gao, Songlin
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Published in
International Journal of Nanomedicine
Purpose Immunologically quiescent of breast cancer cells has been recognized as the key impediment for the breast cancer immunotherapy. In this study, we aimed to investigate the role of nanoparticle-mediated sonodynamic therapy (SDT) in promoting anti-tumor immune of breast cancer cells and its potential immune mechanisms. Materials and Methods Th...
Li, Wanzhen Song, Ping Xin, Ying Kuang, Zhao Liu, Qin Ge, Fei Zhu, Longbao Zhang, Xuguang Tao, Yugui zhang, weiwei
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Published in
International Journal of Nanomedicine
Background With the development of bacterial resistance, the range of effective antibiotics is increasingly becoming more limited. The effective use of nanoscale antimicrobial peptides (AP) in therapeutic and diagnostic methods is a strategy for new antibiotics. Methods Combining both AP and cadmium selenide (CdSe) into a composite material may res...
Yu, Dan Yin, Qilong Wang, Jiwei Yang, Jian Chen, Zimeng Gao, Zihan Huang, Qingli Li, Shibao
Published in
International Journal of Nanomedicine
Purpose Developing a sensitive SERS-based method to quantitatively detect serum biomarkers (Aβ1-42 and P-Tau-181) for the early diagnosis of Alzheimer’s disease (AD). Methods In this study, a novel SERS-based sandwich immunoassay, which consists of tannin-capped silver nanoparticles and magnetic graphene oxide ([email protected]), was developed. We firstly...
Lin, Xiaoning Huang, Rong Huang, Yanlin Wang, Kai Li, Heng Bao, Yiheng Wu, Chaohui Zhang, Yi Tian, Xinhua Wang, Xiaomin
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Published in
International Journal of Nanomedicine
Introduction Sonodynamic therapy (SDT) has good targeting and non-invasive advantages in the treatment of solid cancers, and checkpoint blockade immunotherapy is also a promising treatment to cure cancer. However, their antitumor effects are not sufficient due to some inherent factors. Some studies that combined SDT with immunotherapy or nanopartic...
Du, Xingran Xue, Jianpeng Jiang, Mingzi Lin, Shaoqing Huang, Yuzhen Deng, Kaili Shu, Lei Xu, Hanmei Li, Zeqing Yao, Jing
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Published in
International Journal of Nanomedicine
Background The development of vaccines is a promising and cost-effective strategy to prevent emerging multidrug-resistant (MDR) Acinetobacter baumannii ( A. baumannii ) infections. The purpose of this study was to prepare a multiepitope peptide nanovaccine and evaluate its immunogenicity and protective effect in BALB/c mice. Methods The B-cell and ...
Zarghami Dehaghani, Maryam Bagheri, Babak Yousefi, Farrokh Nasiriasayesh, Abbasali Hamed Mashhadzadeh, Amin Zarrintaj, Payam Rabiee, Navid Bagherzadeh, Mojtaba Fierro, Vanessa Celzard, Alain
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Published in
International Journal of Nanomedicine
Introduction Nanotube-based drug delivery systems have received considerable attention because of their large internal volume to encapsulate the drug and the ability to penetrate tissues, cells, and bacteria. In this regard, understanding the interaction between the drug and the nanotube to evaluate the encapsulation behavior of the drug in the nan...
Zhou, Yanghao Yang, Qiang Wang, Feng Zhou, Zunjie Xu, Jing Cheng, Si Cheng, Yuan
Published in
International Journal of Nanomedicine
Introduction RNA interference is a promising therapy in glioma treatment. However, the application of RNA interference has been limited in glioma therapy by RNA instability and the lack of tumor targeting. Here, we report a novel DNA tetrahedron, which can effectively deliver small interfering RNA to glioma cells and induce apoptosis. Methods siRNA...
Lan, Jin-Shuai Qin, Yan-Hong Liu, Li Zeng, Rui-Feng Yang, Yang Wang, Kai Ding, Yue Zhang, Tong Ho, Rodney J Y
Published in
International Journal of Nanomedicine
Purpose To avoid undefined metabolic mechanisms and to eliminate potential side effects of traditional nanocarriers, new green carriers are urgently needed in cancer treatment. Carrier-free nanoparticles (NPs) based on ursolic acid (UA) have attracted significant attention, but the UA NPs targeting the folate receptor have never been explored. We d...
Mohamad, Soad A Zahran, Eman Maher Abdel Fadeel, Maha Raafat Albohy, Amgad Safwat, Mohamed A
Published in
International Journal of Nanomedicine
Background SARS-COVID-2 has recently been one of the most life-threatening problems which urgently needs new therapeutic antiviral agents, especially those of herbal origin. Purpose The study aimed to load acaciin (ACA) into the new self-assembled nanofibers (NFs) followed by investigating their possible antiviral effect against bovine coronavirus ...
