Usunier, Benoît Brossard, Clément L’Homme, Bruno Linard, Christine Benderitter, Marc Milliat, Fabien Chapel, Alain
Published in
International Journal of Molecular Sciences
Fibrosis is a leading cause of death in occidental states. The increasing number of patients with fibrosis requires innovative approaches. Despite the proven beneficial effects of mesenchymal stem cell (MSC) therapy on fibrosis, there is little evidence of their anti-fibrotic effects in colorectal fibrosis. The ability of MSCs to reduce radiation-i...
Fajkus, Petr Peška, Vratislav Fajkus, Jiří Sýkorová, Eva
Published in
International Journal of Molecular Sciences
The gene coding for the telomerase reverse transcriptase ( TERT ) is essential for the maintenance of telomeres. Previously we described the presence of three TERT paralogs in the allotetraploid plant Nicotiana tabacum , while a single TERT copy was identified in the paleopolyploid model plant Arabidopsis thaliana . Here we examine the presence, or...
Yabuuchi, Nozomi Hou, Huixian Gunda, Nao Narita, Yuki Jono, Hirofumi Saito, Hideyuki
Published in
International Journal of Molecular Sciences
Endogenous factors involved in the progression of cisplatin nephropathy remain undetermined. Here, we demonstrate the toxico-pathological roles of indoxyl sulfate (IS), a sulfate-conjugated uremic toxin, and sulfotransferase 1A1 (SULT1A1), an enzyme involved in its synthesis, in cisplatin-induced acute kidney injury using Sult1a1 -deficient ( Sult1...
Wu, Wenmei Li, Kang Zhao, Haigang Xu, Xianying Xu, Jing Luo, Man Xiao, Yang Tian, Ling
Published in
International Journal of Molecular Sciences
Cyboran-Mikołajczyk, Sylwia Sareło, Przemysław Pasławski, Robert Pasławska, Urszula Przybyło, Magdalena Nowak, Kacper Płóciennik, Michał Podbielska, Halina Kopaczyńska, Marta Wawrzyńska, Magdalena
...
Published in
International Journal of Molecular Sciences
Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidyl...
van de Merbel, Arjanneke F. van Hooij, Onno van der Horst, Geertje van Rijt-van de Westerlo, Cindy C. M. van der Mark, Maaike H. Cheung, Henry Kroon, Jan Verhaegh, Gerald W. Tijhuis, Johan Wellink, Antoine
...
Published in
International Journal of Molecular Sciences
Transformed epithelial cells can activate programs of epithelial plasticity and switch from a sessile, epithelial phenotype to a motile, mesenchymal phenotype. This process is linked to the acquisition of an invasive phenotype and the formation of distant metastases. The development of compounds that block the acquisition of an invasive phenotype o...
Ren, Baiyan Dunaevsky, Anna
Published in
International Journal of Molecular Sciences
Accumulating studies demonstrate the morphological and functional diversity of astrocytes, a subtype of glial cells in the central nervous system. Animal models are instrumental in advancing our understanding of the role of astrocytes in brain development and their contribution to neurological disease; however, substantial interspecies differences ...
Fang, Yao-Ching Wei, Ling-Fei Hu, Chaur-Jong Tu, Yong-Kwang
Published in
International Journal of Molecular Sciences
Moyamoya disease (MMD) is a cerebrovascular disease that presents with vascular stenosis and a hazy network of collateral formations in angiography. However, the detailed pathogenic pathway remains unknown. Studies have indicated that in addition to variations in the of genetic factor RNF213 , unusual circulating angiogenetic factors observed in pa...
Vissers, Maurits F. J. M. Heuberger, Jules A. A. C. Groeneveld, Geert Jan
Published in
International Journal of Molecular Sciences
The clinical failure rate for disease-modifying treatments (DMTs) that slow or stop disease progression has been nearly 100% for the major neurodegenerative disorders (NDDs), with many compounds failing in expensive and time-consuming phase 2 and 3 trials for lack of efficacy. Here, we critically review the use of pharmacological and mechanistic bi...
Rivera, Hernán Mauricio Muñoz, Esther Natalia Osuna, Daniel Florez, Mauro Carvajal, Michael Gómez, Luis Alberto
Published in
International Journal of Molecular Sciences
Background : Many microRNAs have been identified as critical mediators in the progression of melanoma through its regulation of genes involved in different cellular processes such as melanogenesis, cell cycle control, and senescence. However, microRNAs’ concurrent participation in syngeneic mouse B16F1 melanoma cells simultaneously induced decrease...
