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Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G...

Shimizu, Natsumi Noda, Shinichi Katayama, Kazufumi Ichikawa, Hitoshi Kodama, Hiroaki Miyoshi, Hiroyuki

Published in International journal of hematology

Although coculture of hematopoietic stem cells (HSCs) with stromal cells is a useful system to study hematopoiesis in the niche, little is known regarding the precise cellular and molecular mechanisms of maintaining HSCs through cell-cell interactions. The murine preadipose stromal cell line MC3T3-G2/PA6 (PA6) has been demonstrated to support HSCs ...

Differential expression of HOX genes upon activation of leukocyte sub-populations.

Morgan, Richard Whiting, Karen

Published in International journal of hematology

The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expression in resting and activated l...

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Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G...

Differential expression of HOX genes upon activation of leukocyte sub-populations.