Längst, Natalie Adler, Julia Kuret, Anna Peter, Andreas Ruth, Peter Boldt, Karsten Lukowski, Robert
Published in
Cells
Vascular smooth muscle cells (VSMCs) can switch from their contractile state to a synthetic phenotype resulting in high migratory and proliferative capacity and driving atherosclerotic lesion formation. The cysteine-rich LIM-only protein 4 (CRP4) reportedly modulates VSM-like transcriptional signatures, which are perturbed in VSMCs undergoing pheno...
Lima, Matheus Fabiao de Lisboa, Mateus de Oliveira Terceiro, Lucas E L Rangel-Pozzo, Aline Mai, Sabine
Published in
Cells
Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene...
Sonali, Sharma Ray, Bipul Ahmed Tousif, Hediyal Rathipriya, Annan Gopinath Sunanda, Tuladhar Mahalakshmi, Arehally M Rungratanawanich, Wiramon Essa, Musthafa Mohamed Qoronfleh, M Walid Chidambaram, Saravana Babu
...
Published in
Cells
Depression is a highly common mental disorder, which is often multifactorial with sex, genetic, environmental, and/or psychological causes. Recent advancements in biomedical research have demonstrated a clear correlation between gut dysbiosis (GD) or gut microbial dysbiosis and the development of anxiety or depressive behaviors. The gut microbiome ...
Esfandiary, Ali Finkelstein, David Isaac Voelcker, Nicolas Hans Rudd, David
Published in
Cells
Alterations in the sphingolipid metabolism of Parkinson's Disease (PD) could be a potential diagnostic feature. Only around 10-15% of PD cases can be diagnosed through genetic alterations, while the remaining population, idiopathic PD (iPD), manifest without validated and specific biomarkers either before or after motor symptoms appear. Therefore, ...
Szklener, Katarzyna Michalski, Adam Żak, Klaudia Piwoński, Michał Mańdziuk, Sławomir
Published in
Cells
Bruton's Tyrosine Kinase (BTK) is considered crucial in the activation and survival of both physiological and malignant B-cells. In recent years, ibrutinib, an oral BTK inhibitor, became a breakthrough therapy for hematological malignancies, such as chronic lymphocytic. However, ibrutinib's feasibility might not end there. Several other kinases wit...
Sun, Liying Hadidi, Ahmed
Published in
Cells
Viroids were discovered by the American plant pathologist Theodor O [...].
Jardin, Isaac Lopez, Jose J Sanchez-Collado, Jose Gomez, Luis J Salido, Gines M Rosado, Juan A
Published in
Cells
Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all mediated by Ca2+. Ca2+ homeostasis is vital for sev...
Tarban, Nastaran Halász, Hajnalka Gogolák, Péter Garabuczi, Éva Moise, Alexander R Palczewski, Krzysztof Sarang, Zsolt Szondy, Zsuzsa
Published in
Cells
Skeletal muscle repair is initiated by local inflammation and involves the engulfment of dead cells (efferocytosis) by infiltrating macrophages at the injury site. Macrophages orchestrate the whole repair program, and efferocytosis is a key event not only for cell clearance but also for triggering the timed polarization of the inflammatory phenotyp...
Mu, Chaosheng Guo, Xuecheng Chen, Youhua
Published in
Biology
Species distribution models (SDMs) have become indispensable tools in risk assessment and conservation decision-making for invasive species. Eleutherodactylus planirostris has a strong dispersal ability, and the main route of introduction to new regions is likely transport via seedlings. This species is understood as one of the foremost successful ...
Omar, Said A Abdul-Hafez, Amal Ibrahim, Sherif Pillai, Natasha Abdulmageed, Mohammed Thiruvenkataramani, Ranga Prasanth Mohamed, Tarek Madhukar, Burra V Uhal, Bruce D
Published in
Cells
Premature newborns are at a higher risk for the development of respiratory distress syndrome (RDS), acute lung injury (ALI) associated with lung inflammation, disruption of alveolar structure, impaired alveolar growth, lung fibrosis, impaired lung angiogenesis, and development of bronchopulmonary dysplasia (BPD) with severe long-term developmental ...