Przysucha, Natalia Górska, Katarzyna Krenke, Rafal
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Chitinases, enzymes that cleave chitin’s chain to low molecular weight chitooligomers, are widely distributed in nature. Mammalian chitinases belong to the 18-glycosyl-hydrolase family and can be divided into two groups: true chitinases with enzymatic activity (AMCase and chitotriosidase) and chitinase-like proteins (CLPs) molecules which can bind ...
Welling, Jorrit B A Hartman, Jorine E Augustijn, Sonja W S Kerstjens, Huib A M Vanfleteren, Lowie E G W Klooster, Karin Slebos, Dirk-Jan
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Purpose Bronchoscopic lung volume reduction (BLVR) is a valuable treatment option for carefully selected patients with severe COPD. There is limited knowledge about the characteristics and outcomes of patients referred to a specialized center for BLVR. The study objectives were to investigate the selection rate for BLVR treatment in patients referr...
Yamaya, Mutsuo Usami, Osamu Nakayama, Shoichi Tode, Naoki Yamada, Aya Ito, Shunsuke Omata, Fumiya Momma, Haruki Funakubo, Masakatsu Ichinose, Masakazu
...
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Background Different characteristics of patients with chronic obstructive pulmonary disease (COPD) between Western and Japanese populations have been reported. Risk factors for COPD exacerbation have been reported in Western countries but have not been studied in Japan. Patients and Methods We retrospectively examined risk factors for COPD exacerba...
Brighton, Lisa Jane Evans, Catherine J Man, William D C Maddocks, Matthew
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Background People living with both chronic obstructive pulmonary disease (COPD) and frailty have high potential to benefit from exercise-based interventions, including pulmonary rehabilitation, but face challenges completing them. Research to understand ways to optimise exercise-based interventions in this group is lacking. We aimed to understand h...
Tantucci, Claudio Pini, Laura
Published in
International Journal of Chronic Obstructive Pulmonary Disease
The use of inhaled corticosteroids (ICSs) in long-term treatment of COPD has been a debated topic for a long time. According to the evidence produced till now, ICSs are presently advocated in combination with long-acting bronchodilators for high-risk symptomatic COPD patients with a history of frequent COPD exacerbations. However, the heterogeneity...
Yong, Seung Hyun Leem, Ah Young Kim, Young Sam Park, Moo Suk Chang, Joon Kim, Seung Up Jung, Ji Ye
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Background Various comorbidities influence the prognosis of patients with chronic obstructive pulmonary disease (COPD). We investigated if liver fibrosis assessed using fibrosis-4 index (FIB-4) is associated with all-cause mortality in patients with COPD. Methods We included 756 patients diagnosed with COPD between 2006 and 2010. Medical records we...
Zhong, Nanshan Zheng, Jinping Lee, Sang Haak Lipson, David A Du, Xin Wu, Shunquan
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Purpose Previous studies demonstrating efficacy and safety of once-daily umeclidinium (UMEC) in patients with chronic obstructive pulmonary disease (COPD) have included few Asian patients. This study evaluated efficacy and safety of UMEC 62.5 mcg versus placebo in Asian patients with COPD. Patients and Methods A Phase III, randomized, double-blind,...
Lakhotia, Bhavesh Mahon, Ronan Gutzwiller, Florian S Danyliv, Andriy Nikolaev, Ivan Thokala, Praveen
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Purpose Exacerbations drive outcomes and costs in chronic obstructive pulmonary disease (COPD). While patient-level (micro) simulation cost-effectiveness models have been developed that include exacerbations, such models are complex. We developed a novel, exacerbation-based model to assess the cost-effectiveness of indacaterol/glycopyrronium (IND/G...
Holm, Are M Andreassen, Siw L Christensen, Vivi Lycke Kongerud, Johny Almås, Øystein Auråen, Henrik Henriksen, Anne H Aaberge, Ingeborg S Klingenberg, Olav Rustøen, Tone
...
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Introduction Chronic obstructive pulmonary disease (COPD) may, in some patients, be characterized by recurring acute exacerbations. Often these exacerbations are associated with airway infections. As immunoglobulins (Ig) are important parts of the immune defence against airway infections, the aim of this study was to relate the levels of circulatin...
Ding, Bo Kallenbach, Lee Slipski, Lukas Wilk, Alan O’Brien, Dan Guranlioglu, Deniz
Published in
International Journal of Chronic Obstructive Pulmonary Disease
Introduction This retrospective, observational cohort study utilized an integrated dataset from an electronic health records system and a claims database to describe demographic and clinical characteristics, healthcare resource utilization (HCRU), and treatment patterns in COPD patients initiating long-acting muscarinic antagonist (LAMA)/long-actin...
