Dai, Xiaofeng Cai, Dongyan Wang, Peiyu Nan, Nan Yu, Lihui Zhang, Zhifa Zhou, Renwu Hua, Dong Zhang, Jianying Ostrikov, Kostya Ken
...
Published in
International journal of biological sciences
Cold atmospheric plasma (CAP) is selective against many cancers with little side effect, yet its molecular mechanism remains unclear. Through whole transcriptome sequencing followed by assays in vitro, in vivo and using clinical samples, we propose CAP as a promising onco-therapy targeting cancer stemness via the AQP3/FOXO1 axis. CAP-generated reac...
Zhang, Qing Chen, Wen Wen Sun, Xue Qian, Die Tang, Dan Dan Zhang, Li Lin Li, Mei Yan Wang, Lin Yu Wu, Chun-Jie Peng, Wei
...
Published in
International journal of biological sciences
Cancers are generally recognized as the leading cause of death and a predominant barrier to prolonging life expectancy in both developed and developing countries. Emodin is a typical anthraquinone derivative from various plants that exhibits a wide spectrum of biological activities, such as anticancer, antibacterial, hepatoprotective and anti-infla...
Peng, Shengmeng Chen, Xu Huang, Chaoyun Yang, Chenwei Situ, Minyi Zhou, Qianghua Ling, Yihong Huang, Hao Huang, Ming Zhang, Yangjie
...
Published in
International journal of biological sciences
Bone metastasis is the main site of metastasis and causes the most deaths in patients with prostate cancer (PCa). The mechanism of bone metastasis is complex and not fully clarified. By RNA sequencing and analysing key pathways in bone metastases of PCa, we found that one of the most important characteristics during PCa bone metastasis was G1/S tra...
Yang, Jiefeng Luo, Li Zhao, Chongyu Li, Xiyuan Wang, Zimo Zeng, Ziwei Yang, Xin Zheng, Xiaobin Jie, Haiqing Kang, Liang
...
Published in
International journal of biological sciences
Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal cell carcinoma (ccRCC). Here, we identify a previously unknown oncogenic role for inactive VHL in actively triggering histone lactylation to promote ccRCC progression. In patients with ccRCC, inactive VHL positively ...
Zhang, Huan Yu, Haixin Ren, Dianyuan Sun, Yan Guo, Feng Cai, Hongkun Zhou, Chen Zhou, Yingke Jin, Xin Wu, Heshui
...
Published in
International journal of biological sciences
As a key reversible and heritable mechanism of transcriptional regulation, the epigenetic modification plays a crucial role in tumorigenesis. Of note, tobacco smoking induces epigenetic modifications to promote pancreatic cancer development. Chromobox protein homolog 3 (CBX3) acts as an epigenetic regulator, modulating gene expression of downstream...
Dong, Haonan Zhang, Lu Liu, Suling
Published in
International journal of biological sciences
HMGB1 is a member of highly conserved high mobility group protein superfamily with intracellular and extracellular distribution. Abnormal HMGB1 levels are frequently manifested in various malignant diseases, including breast cancer. Numerous studies have revealed the clinical value of HMGB1 in the diagnosis and therapy of breast cancer. However, th...
Liu, Zhuang Xiao, Mingming Mo, Yaqi Wang, Han Han, Yamei Zhao, Xu Yang, Xue Liu, Zhenxing Xu, Bo
Published in
International journal of biological sciences
Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoylation is crucial for many tumor-related signaling pathways, such as EGFR, RAS, PD-1/PD-L1 signaling, affecting t...
Liu, Ming Li, Pei Jia, Yuanyuan Cui, Qingjun Zhang, Kexin Jiang, Jingjing
Published in
International journal of biological sciences
Peripheral nerve injury (PNI) may lead to disability and neuropathic pain, which constitutes a substantial economic burden to patients and society. It was found that the peripheral nervous system (PNS) has the ability to regenerate after injury due to a permissive microenvironment mainly provided by Schwann cells (SCs) and the intrinsic growth capa...
Han, Peiyu Shen, Li Nan, Nan Zhou, Renwu Li, Tianci Dai, Xiaofeng
Published in
International journal of biological sciences
Objectives: Vaccination still remains as the most effective approach for preventing infectious diseases such as those caused by virus infection, with cell-based vaccine manufacturing being one flexible solution regarding the spectrum of infectious disorders it can prevent. Rapid cell-based virus propagation can enable high yield of vaccines against...
Zhou, Diyuan Yao, Yizhou Zong, Liang Zhou, Guoqiang Feng, Min Chen, Junjie Liu, Ganggang Chen, Guoliang Sun, Kang Yao, Huihui
...
Published in
International journal of biological sciences
Intestinal inflammation is a vital precipitating factor of colorectal cancer (CRC), but the underlying mechanisms are still elusive. TANK-binding kinase 1 (TBK1) is a core enzyme downstream of several inflammatory signals. Recent studies brought the impacts of TBK1 in malignant disease to the forefront, we found aberrant TBK1 expression in CRC is c...
