Fantini, Jacques Chahinian, Henri Yahi, Nouara
Published in
International Journal of Antimicrobial Agents
The emergence of SARS-coronavirus-2 (SARS-CoV-2) is responsible for a global pandemic disease referred to as coronavirus disease 19 (Covid-19). Hydroxychloroquine/azithromycin combination therapy is currently tested for curing Covid-19, with promising results. However, the molecular mechanism of action of this combination is not established yet. Us...
A., Ciccullo A., Borghetti L., Zileri Dal Verme A., Tosoni F., Lombardi M., Garcovich F., Biscetti M., Montalto R., Cauda S., Di Giambenedetto
...
Published in
International Journal of Antimicrobial Agents
• Clinicians are looking for a reliable prognostic marker for patients with COVID-19 • In our cohort, clinical improvement was predicted by younger age and a NLR below 3 • Transfer to ICU was instead predicted by a NLR over 4 (p=0.046) • NLR is a fast, widely available and relatively inexpensive assessment • NLR may be a useful tool in the early sc...
Yu, Ran Chen, Liang Lan, Rong Shen, Rong Li, Peng
Published in
International Journal of Antimicrobial Agents
In the current episode of novel coronavirus (SARS-CoV-2) spreads, antiviral drug discovery is of great importance. Auto dock vina was used to screen potential drugs by molecular docking with the structure protein and non-structure protein sites of new coronavirus. Ribavirin, a common antiviral drug, as well as remdesivir, chloroquine and luteolin, ...
Derendorf, Hartmut
Published in
International Journal of Antimicrobial Agents
A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects. ...
Vikse, Jens Henry, Brandon Michael
Published in
International Journal of Antimicrobial Agents
Deslandes, A Berti, V Tandjaoui-Lambotte, Y Alloui, Chakib Carbonnelle, E Zahar, J R Brichler, S Cohen, Yves
Published in
International journal of antimicrobial agents
The COVID-19 epidemic is believed to have started in late January 2020 in France. Here we report a case of a patient hospitalised in December 2019 in an intensive care unit in a hospital in the north of Paris for haemoptysis with no aetiological diagnosis. RT-PCR was performed retrospectively on the stored respiratory sample and confirmed the diagn...
Fantini, Jacques Di Scala, Coralie Chahinian, Henri Yahi, Nouara
Published in
International Journal of Antimicrobial Agents
Image, graphical abstract
Kara, Emre Inkaya, Ahmet Cagkan Demirkan, Prof. Dr. Kutay
Published in
International Journal of Antimicrobial Agents
Smieszek, Sandra P. Przychodzen, Bart P Polymeropoulos, Mihael H.
Published in
International Journal of Antimicrobial Agents
SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on cleavage of the spike protein by the host cell proteases such as Cathepsin L and Cathepsin B. CTSL/B are crucial elements of lysosomal pathway and both enzymes are almost ...
Lai, Chih-Cheng Wang, Cheng-Yi Wang, Ya-Hui Hsueh, Po-Ren
Published in
International journal of antimicrobial agents
In addition to the absolute case number, a rapid increase in the number of COVID-19 cases within a short time results in insufficiency of healthcare systems and further negatively affects patient outcomes. This study was conducted to investigate the association between the outcomes of COVID-19 patients and daily cumulative index (DCI), which was de...
