Simon, Hans-Uwe Yousefi, Shida Germic, Nina Arnold, Isabelle C. Haczku, Angela Karaulov, Alexander V. Simon, Dagmar Rosenberg, Helene F.
Published in
International Archives of Allergy and Immunology
Eosinophils and their secretory mediators play an important role in the pathogenesis of infectious and inflammatory disorders. Although eosinophils are largely evolutionally conserved, their physiologic functions are not well understood. Given the availability of new eosinophil-targeted depletion therapies, there has been a renewed interest in unde...
Chen, Qiao-bin Chen, Lang Zheng, Xiao-yin Zheng, Xin Fang, Qiong Xiao, Meng Lin, Xiao-ting
Published in
International Archives of Allergy and Immunology
Background: Allergic rhinitis is an allergic inflammation of the nasal airways, and chronic rhinosinusitis is an inflammation of the paranasal sinuses. It can be induced by infection, allergy, or autoimmune problems. Diagnosis of these two diseases is made primarily based on clinical symptoms, allergen test, and imaging. The allergen test is invasi...
Kakolyri, Maria Strikou, Flora Kavallari, Andriana Chliva, Caterina Makris, Michael Tiligada, Ekaterini
Published in
International Archives of Allergy and Immunology
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive. Objectives: This study aimed to explore the con...
Butterfield, Joseph H.
Published in
International Archives of Allergy and Immunology
Introduction: Although 4 mast cell mediators can be routinely measured, the results of initial testing to evaluate symptoms of mast cell activation have not been widely reported. Objective: We examined the results of mast cell mediator tests used to assess patients with mast cell activation symptoms during a 5-year time span. Methods: After excludi...
Xian, Mo Feng, Mulin Dong, Yan Wei, Nili Su, Qiujuan Li, Jing
Published in
International Archives of Allergy and Immunology
Background: Few studies have directly compared the immunologic responses to specific subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Objective: We aimed to directly compare clinical efficacy and immunological responses between SLIT and SCIT in allergic rhinitis (AR) sensitized to house dust mites. Methods: Sixty-seven patient...
Szymczak-Pajor, Izabela Kleniewska, Paulina Wieczfinska, Joanna Pawliczak, Rafal
Published in
International Archives of Allergy and Immunology
Introduction: Phospholipases are enzymes that occur in many types of human cells, including mast cells, and play an important role in the molecular background of asthma pathogenesis, and the development of inflammation NF-κB activities that affect numerous biological processes has been reported in many inflammatory diseases including asthma. Vitami...
Verschoor, Daniëlle von Gunten, Stephan
Published in
International Archives of Allergy and Immunology
Over the last decades, an increasing appearance of allergies and atopic disorders, such as asthma, dermatitis, and rhinitis, has been observed. The mechanisms of these disorders remain unclear, and therefore the development of novel therapies is limited. Current treatments are often symptomatic, nonspecific, or may have severe side effects. Further...
Loo, Evelyn Xiu Ling Wang, De Yun Siah, Kewin Tien Ho
Published in
International Archives of Allergy and Immunology
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease and the most common cause of prolonged abdominal pain and bowel disturbances in the developed world. While initially thought to be functional or psychosomatic in nature, IBS is now recognized as a heterogeneous group of conditions. A subset of IBS patients and patients with all...
Simon, Dagmar
Published in
International Archives of Allergy and Immunology
The immune system has vital functions for homeostasis and host defense. Thus, imbalances of the immune system whether associated with allergy, hypersensitivity, or autoimmunity are of great importance, as is manifest from common diseases such as atopic diseases, urticaria, and angioedema, and drug hypersensitivity reactions. These can affect patien...
Kopp, Matthias Volkmar König, Inke R. Friedrichs, Frank Umpfenbach, Hans Ulrich Niggemann, Bodo Millner-Uhlemann, Martina
Published in
International Archives of Allergy and Immunology
Background: Numerous products are available for subcutaneous (SCIT) and sublingual allergen-specific immunotherapy, but there are no information about the direct comparability regarding efficacy, safety, and tolerability of the different extracts. Aims: The aim of this open-labelled, prospective, controlled observational trial was to test the feasi...
