The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple so...
Published in Intensive Care Medicine
The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple so...
The physiological underpinnings of life-saving respiratory support
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Published in Intensive Care Medicine
Treatment of respiratory failure has improved dramatically since the polio epidemic in the 1950s with the use of invasive techniques for respiratory support: mechanical ventilation and extracorporeal respiratory support. However, respiratory support is only a supportive therapy, designed to “buy time” while the disease causing respiratory failure a...
How to manage anticoagulation during extracorporeal membrane oxygenation
Published in Intensive Care Medicine
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care u...
Published in Intensive Care Medicine
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controll...
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Published in Intensive Care Medicine
Purpose Epidemiologic studies have documented lower rates of active smokers compared to former or non-smokers in symptomatic patients affected by coronavirus disease 2019 (COVID-19). We assessed the efficacy and safety of nicotine administered by a transdermal patch in critically ill patients with COVID-19 pneumonia. Methods In this multicentre, do...
Mental health morbidity, self-harm, and suicide in ICU survivors and caregivers
Published in Intensive Care Medicine
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a ...
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Published in Intensive Care Medicine
Purpose In acute respiratory distress syndrome (ARDS), physiological parameters associated with outcome may help defining targets for mechanical ventilation. This study aimed to address whether transpulmonary pressures ( P L), including transpulmonary driving pressure (DPL), elastance-derived plateau P L, and directly-measured end-expiratory P L, a...
Increased risk of central line-associated bloodstream infection in COVID-19 patients associated with dexamethasone but n...
Published in Intensive Care Medicine
Prone position in mechanically ventilated patients
Published in Intensive Care Medicine
Beyond failure or success: reflections on the ethical justifications for time-limited trial of intensive care
Published in Intensive Care Medicine
