Broor, Shobha Campbell, Harry Hirve, Siddhivinayak Hague, Siri Jackson, Sandra Moen, Ann Nair, Harish Palekar, Rakhee Rajatonirina, Soatiana Smith, Peter G
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Published in
Influenza and other respiratory viruses
Respiratory syncytial virus (RSV)-associated acute lower respiratory infection is a common cause for hospitalization and hospital deaths in young children globally. There is urgent need to generate evidence to inform immunization policies when RSV vaccines become available. The WHO piloted a RSV surveillance strategy that leverages the existing cap...
Lei, Hui Ye, Feng Liu, Xiaoqing Huang, Zhenting Ling, Shiman Jiang, Zhanpeng Cheng, Jing Huang, Xiaoqun Wu, Qiubao Wu, Shiguan
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Published in
Influenza and other respiratory viruses
Severe COVID-19 patients typically test positive for SARS-CoV-2 RNA for extended periods of time, even after recovery from severe disease. Due to the timeframe involved, these patients may have developed humoral immunity to SARS-CoV-2 while still testing positive for viral RNA in swabs. Data are lacking on exposure risks in these situations. Here, ...
Kong, Dechuan Zheng, Yang Wu, Huanyu Pan, Hao Wagner, Abram L Zheng, Yaxu Gong, Xiaohuan Zhu, Yiyi Jin, Bihong Xiao, Wenjia
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Published in
Influenza and other respiratory viruses
We used contact tracing to document how COVID-19 was transmitted across 5 generations involving 10 cases, starting with an individual who became ill on January 27. We calculated the incubation period of the cases as the interval between infection and development of symptoms. The median incubation period was 6.0 days (interquartile range, 3.5-9.5 da...
Xia, Jing Adam, Dillon C Moa, Aye Chughtai, Abrar A Barr, Ian G Komadina, Naomi MacIntyre, C Raina
Published in
Influenza and other respiratory viruses
Over the last two decades, Australia has experienced four severe influenza seasons caused by a predominance of influenza A (A/H3N2): 2003, 2007, 2012, and 2017. We compared the epidemiology, genetics, and transmission dynamics of severe A/H3N2 seasons in Australia from 2003 to 2017. Since 2003, the proportion of notifications in 0-4 years old has d...
Cai, Wei Tolksdorf, Kristin Hirve, Siddhivinayak Schuler, Ekkehard Zhang, Wenqing Haas, Walter Buda, Silke
Published in
Influenza and other respiratory viruses
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection (ALRI) in young children. ICD-10-based syndromic surveillance can transmit data rapidly in a standardized way. We investigated the use of RSV-specific ICD-10 codes for RSV surveillance. We performed a retrospective descriptive data analysis based o...
Chadha, Mandeep Hirve, Siddhivinayak Bancej, Christina Barr, Ian Baumeister, Elsa Caetano, Braulia Chittaganpitch, Malinee Darmaa, Badarch Ellis, Joanna Fasce, Rodrigo
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Published in
Influenza and other respiratory viruses
Human respiratory syncytial virus (RSV) causes illnesses among all age groups and presents a burden to healthcare services. To better understand the epidemiology and seasonality of RSV in different geographical areas, the World Health Organization (WHO) coordinated a pilot initiative to access the feasibility of establishing RSV surveillance using ...
Cai, Wei Buda, Silke Schuler, Ekkehard Hirve, Siddhivinayak Zhang, Wenqing Haas, Walter
Published in
Influenza and other respiratory viruses
Respiratory syncytial virus (RSV) is a major cause of hospital admission for acute lower respiratory tract infection in young children. We aimed to identify risk factors for hospitalized RSV disease and its severe outcomes. We conducted a retrospective cohort study analyzing data of a ICD-10-code-based hospital surveillance for severe acute respira...
Pebody, Richard Moyes, Jocelyn Hirve, Siddhivinayak Campbell, Harry Jackson, Sandra Moen, Ann Nair, Harish Simões, Eric A F Smith, Peter G Wairagkar, Niteen
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Published in
Influenza and other respiratory viruses
The World Health Organization (WHO) recently completed the first phase of a RSV surveillance pilot study in fourteen countries (two to three in each WHO region) building on the Global Influenza Surveillance and Response System (GISRS). This active surveillance strategy had several objectives including understanding RSV-related health burden in a va...
Hirve, Siddhivinayak Crawford, Nigel Palekar, Rakhee Zhang, Wenqing
Published in
Influenza and other respiratory viruses
The lack of a uniform surveillance case definition poses a challenge to characterize the epidemiology, clinical features, and disease burden of the respiratory syncytial virus (RSV). Global standards for RSV surveillance will inform immunization policy when RSV vaccines become available. The WHO RSV surveillance pilot leverages the capacities of th...
Quandelacy, Talia M Cummings, Derek A T Jiang, Chao Qiang Yang, Bingyi Kwok, Kin On Dai, Byran Shen, Ruiyin Read, Jonathan M Zhu, Huachen Guan, Yi
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Published in
Influenza and other respiratory viruses
Influenza infection is often measured by a fourfold antibody titer increase over an influenza season (ie seroconversion). However, this approach may fail when influenza seasons are less distinct as it does not account for transient effects from recent infections. Here, we present a method to determine seroconversion for non-paired sera, adjusting f...
