Ye, Zhinan Hu, Jingchun Xu, Hao Sun, Bin Jin, Yong Zhang, Yaping Zhang, Jianli
Published in
Inflammation
Acute cerebral infarction (ACI) possesses high mortality. Exosomes present in serum have potential application value in ACI diagnosis. This study investigated the mechanism of serum exosomes in ACI. Serum exosomes isolated from ACI patients and normal people were identified and then injected into the established middle cerebral artery occlusion (MC...
Yang, Luting Xia, Haibin
Published in
Inflammation
Inflammation is an immune response to exogenous or endogenous insults that helps to maintain the tissue homeostasis under stressful conditions. Depending on the differential types of insults, inflammation is classified into microbial, autoimmune, metabolic, allergic, and physical inflammation. With regard to its involvement in the pathogenesis of m...
de França, Juliane Santos de Sales-Neto, José Marreiro Carvalho, Deyse Cristina Madruga de Almeida Lima, Éssia Olegário, Tayná Rodrigues Mendes, Rhuan Karlos Santos Lima-Junior, Claudio Gabriel de Almeida Vasconcellos, Mário Luiz Araú... Rodrigues-Mascarenhas, Sandra
Published in
Inflammation
Morita-Baylis-Hillman adducts (MBHA) are synthetic molecules with several biological actions already described in the literature. It has been previously described that adduct 2-(3-hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) has anticancer potential in leukemic cells. Inflammation is often associated with the development and progression of cance...
Gupta, Kunj Bihari Mantha, Anil K Dhiman, Monisha
Published in
Inflammation
Wheat is a major diet from many years; apart from its nutritious value, the wheat protein gliadin is responsible for many inflammatory diseases like celiac disease (CD), and non-celiac gluten sensitivity (NCGS). In this study, the gliadin-induced inflammation and associated cellular damage along with the protective role of curcumin was evaluated us...
Zou, Kang Chen, Wenbo Dai, Jun Mo, Pingli Yu, Chundong Xu, Jianming Wu, Sangang Zhuo, Rengong Su, Guoqiang
Published in
Inflammation
Inflammation theory has suggested that the pathogenesis of postoperative ileus (POI) involves the steroid receptor coactivator-3 (SRC-3). Therefore, we investigated the role of SRC-3 in the muscles of the small intestine using a mouse POI model. Here, we reported that intestinal manipulation (IM) significantly reduced the extent of phenol red migra...
Bhardwaj, Deepika Saxena, Rajiv K
Published in
Inflammation
The present study is focused on the modulation of Mycobacterium bovis BCG-induced inflammatory response by poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) in macrophages. Flow cytometric and confocal microscopy studies indicated that both BCG and AF-SWCNTs were efficiently internalized by RAW 264.7 and MH-S macrophage ...
Li, Lun Liu, Yi Chiu, Chin Jin, Yang Zhou, Weixun Peng, Min Chen, Lung-Chi Sun, Qinghua Gao, Jinming
Published in
Inflammation
Chronic obstructive pulmonary disease (COPD)/pulmonary emphysema is driven by the dysregulated airway inflammation and primarily influenced by the interaction between cigarette smoking (CS) and the individual's susceptibility. The inflammation in COPD involves both innate and adaptive immunity. By binding to its specific ligands, chemokine receptor...
Gomes da Silva, Isaura Isabelle Fonseca Lima, Camilla Albertina Dantas Silva, José Eduardo Adelino Rushansky, Eliezer Mariano, Maria Helena Queiroz Araujo Rolim, Patrícia Oliveira, Renê Donizeti Ribeiro Louzada-Júnior, Paulo Souto, Fabricio Oliveira Crovella, Sergio
...
Published in
Inflammation
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several cytokines from the toll-like receptors activation pathway display recognized role for RA establishment. However, few studies have verified the role of key mediators such as MYD88 gene and its genetic...
Gutzeit, Ola Segal, Linoy Korin, Ben Iluz, Roee Khatib, Nizar Dabbah-Assadi, Fadwa Ginsberg, Yuval Fainaru, Ofer Ross, Michael G Weiner, Zeev
...
Published in
Inflammation
Progesterone has been shown to regulate immunity during pregnancy, and progesterone administration may reduce inflammation-induced preterm labor. We sought to determine the maternal brain immune response to LPS-induced inflammation in pregnant and non-pregnant mice and whether additional progesterone supplementation attenuates this response. Pregna...
Cao, Xiangyuan Wang, Yida Gao, Liang
Published in
Inflammation
Cerebral ischemia-reperfusion (I/R) injury is an inflammation-related disease. CHRFAM7A can regulate inflammatory responses. Therefore, the present study investigated the mechanism of CHRFAM7A in cerebral I/R injury. CHRFAM7A expression and inflammatory cytokine levels in patients with cerebral I/R injury and oxygen-glucose deprivation/reperfusion ...
