Sirisolla, Janakidevi Ramanamurthy, K V
Published in
Indian journal of pharmaceutical sciences
The objective of the present work is to design sustained release matrix tablets of cefixime trihydrate by incorporating drug in a matrix made up of release retardant polymers, which prolong drug release leading to minimization of the peak and valley effect in the plasma and provide patient convenience. The effect of combination of polymers on param...
Nade, Vandana S Kawale, L A Patel, K M
Published in
Indian journal of pharmaceutical sciences
The present investigation aimed to evaluate the protective effects of sitagliptin, glimepiride, rosuvastatin and their combinations on oxidative stress and endothelial dysfunction in the aortic tissues in fructose-fed type-2 diabetic rats. Sitagliptin (20 mg/kg, p.o.), glimepiride (2 mg/kg, p.o.), rosuvastatin (5 mg/kg, p.o.) and their combinations...
Rajamma, A J Sateesha, S B Narode, M K Prashanth, V R S S Karthik, A M
Published in
Indian journal of pharmaceutical sciences
Since the introduction of gliclazide in the pharmaceutical industry, a large number of research groups have been engaged in various investigations aiming to enhance its biomedical application. But, very limited efforts have been made to study polymorphism of gliclazide. Therefore, this study focuses on solvent-induced polymorphism of gliclazide and...
Li, Y Sun, H Y Yu, X Y Liu, D Wan, H X
Published in
Indian journal of pharmaceutical sciences
The cell-based antioxidant activity assay as more biological relevant assay was considered to be more accurate to predict antioxidant activity in vivo than chemical activity assays. In the present study, the five main Phyllanthus emblica L. cultivars in China were subjected for cellular antioxidant activity based on HepG2 cells as well as antiproli...
Tariq, M Negi, L M Talegaonkar, Sushama Ahmad, F J Iqbal, Zeenat Khan, A M
Published in
Indian journal of pharmaceutical sciences
The present work is aimed to develop a simple, sensitive, robust and reliable HPLC method for the estimation of irinotecan in the physiological media in order to assess the permeability profile of irinotecan, using the everted gut sac, in the presence of various P-gp modulators. Separation was achieved using, C18 column with mobile phase consisting...
Kalyankar, P Panzade, P Lahoti, S
Published in
Indian journal of pharmaceutical sciences
The objective of present study was to formulate directly compressible orodispersible tablets of quetiapine fumarate by sublimation method with a view to enhance patient compliance. A full 3(2) factorial design was used to investigate the effect of two variables viz., concentration of Indion 414 and camphor. Indion 414 (3-5 % w/w) was used as superd...
Gurram, A K Deshpande, P B Kar, S S Nayak, Usha Y Udupa, N Reddy, M S
Published in
Indian journal of pharmaceutical sciences
Pharmaceutical research is focused in designing novel drug delivery systems to improve the bioavailability of poorly water soluble drugs. Self-microemulsifying drug delivery systems, one among the lipid-based dosage forms were proven to be promising in improving the oral bioavailability of such drugs by enhancing solubility, permeability and avoidi...
Patil, S Sharma, R Abhishek, A
Published in
Indian journal of pharmaceutical sciences
Comparative study was performed on 34 β-amino amide derivatives as dipeptidyl peptidase IV inhibitors in order to determine their structural requirement to enhance the antidiabetic activities. Hologram quantitative structure activity relationships models utilized specialized fragment fingerprints (hologram length 353) which showed good predictivity...
Khan, R A Bakry, M M Islahudin, F
Published in
Indian journal of pharmaceutical sciences
Inappropriate initial antibiotics for pneumonia infection are usually linked to extended intensive care unit stay and are associated with an increased risk of mortality. This study evaluates the impact of inappropriate initial antibiotics on the length of intensive care unit stay, risk of mortality and the co-predictors that influences these outcom...
Mahitha, B Archana, P Ebrahimzadeh, Md H Srikanth, K Rajinikanth, M Ramaswamy, N
Published in
Indian journal of pharmaceutical sciences
Cajanus cajan (L.) Millsp is one of the second most dietary legume crops. The leaf extracts may be used as a potential source of natural antioxidant. The ash values, extractive values, total phenolic and flavonoid content, in vitro antioxidant activity of various leaf extracts as well as anatomical investigation of Cajanus cajan were carried out. P...
