Agarwal, T Asthana, Somya Bissoyi, A
Published in
Indian journal of pharmaceutical sciences
Chikungunya is one of the tropical viral infections that severely affect the Asian and African countries. Absence of any suitable drugs or vaccines against Chikungunya virus till date makes it essential to identify and develop novel leads for the same. Recently, nsP2 cysteine protease has been classified as a crucial drug target to combat infection...
Asthana, S Agarwal, T Singothu, S Samal, A Banerjee, I Pal, K Pramanik, K Ray, S S
Published in
Indian journal of pharmaceutical sciences
Pueraria tuberosa is known for its therapeutic potentials in cardiovascular disorders, but its effect in angiogenesis has not been studied so far. In this study, a computational approach has been applied to elucidate the role of the phytochemicals in inhibition of angiogenesis through modulation of vascular endothelial growth factor receptors: Vasc...
Stasevych, M Zvarych, V Lunin, V Halenova, T Savchuk, O Dudchak, O Vovk, M Novikov, V
Published in
Indian journal of pharmaceutical sciences
The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studie...
Rajamma, A J Sateesha, S B Narode, M K Prashanth, V R S S Karthik, A M
Published in
Indian journal of pharmaceutical sciences
Since the introduction of gliclazide in the pharmaceutical industry, a large number of research groups have been engaged in various investigations aiming to enhance its biomedical application. But, very limited efforts have been made to study polymorphism of gliclazide. Therefore, this study focuses on solvent-induced polymorphism of gliclazide and...
Sarfraz, R M Khan, H U Mahmood, A Ahmad, M Maheen, S Sher, M
Published in
Indian journal of pharmaceutical sciences
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effe...
Liu, S H Sun, S W Tian, Z F Wu, J Y Li, X L Xu, C P
Published in
Indian journal of pharmaceutical sciences
This work was to investigate the hypoglycemic and antioxidant activities of the exopolysaccharides produced in a stirred-tank bioreactor by Inocutus hispidus. The exopolysaccharides showed significant antioxidant activities, up to 70.7±2.5% inhibition of hydroxyl radicals, 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radicals, and a Trolox equiv...
Shokri, Narges Javar, H A
Published in
Indian journal of pharmaceutical sciences
Dermal drug delivery is highly preferred by patients due to its several advantages. Protein therapeutics have attracted huge attention recently. Since dermal delivery of proteins encounter problems, in this investigation, zinc oxide nanoparticles and calcium phosphate nanoparticles were compared as enhancers for dermal permeation of albumin. Albumi...
Singh, C L Singh, A Kumar, S Kumar, M Sharma, P K Majumdar, D K
Published in
Indian journal of pharmaceutical sciences
In the present study a simple, accurate, precise, economical and specific UV-spectrophotometric method for estimation of besifloxacin in bulk and in different pharmaceutical formulation has been developed. The drug shows maximum λmax289 nm in distilled water, simulated tears and phosphate buffer saline. The linearity range of developed methods were...
Yang, C Liu, C Zhou, Q Xie, Y C Qiu, X M Feng, X
Published in
Indian journal of pharmaceutical sciences
The aim of the study was to elucidate the therapeutic effects of Atracylodes rhizome polysaccharide on adenine-induced chronic renal failure in rats. Fifty male Sprague Dawley rats were selected and randomly divided in to 5 groups (n=10 rats per group): The normal control group, the chronic renal failure pathological control group, the dexamethason...
Velho-Pereira, Sheryanne Parvatkar, P Furtado, Irene J
Published in
Indian journal of pharmaceutical sciences
Marine invertebrates exposed to high levels of reactive oxygen species in the oceans have been reported to produce antioxidants as a major defense against free radical mediated toxicity; protecting their tissues from the damage associated with the oxidative stress. In view of this, the present study was carried out to determine the antioxidant acti...
