WATANABE, HAYATO YAMADA, TAKANOBU KOMORI, KEISUKE HARA, KENTARO KANO, KAZUKI TAKAHASHI, KOSUKE KUMAZU, YUTA FUJIKAWA, HIROHITO NUMATA, MASAKATSU AOYAMA, TORU
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Published in
In Vivo
Background/Aim: We hypothesised that the prognostic nutrition index (PNI) is useful for evaluating host immunity and response to immune checkpoint inhibitors. We investigated the effect of PNI on nivolumab monotherapy efficacy in advanced or recurrent gastric cancer (GC) or gastro-oesophageal junction cancer (GOC) patients. Patients and Methods: We...
ZWICKER, FELIX HAUSWALD, HENRIK WEBER, KLAUS-JOSEF DEBUS, JÜRGEN UBER, E. PETER
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In Vivo
Background/Aim: Casein kinase 2 (CK2) which sustains multiple pro-survival functions in cellular DNA-damage response, is strictly regulated in normal cells but elevated in cancer. CK2 is considered as a potential therapeutic target, and its inhibition has been associated with radiosensitization in mammalian cells in vitro. Here, we investigated pot...
OKADA, YUKA OZAWA, TSUYOSHI HAYAMA, TAMURO OHNO, KOHEI TSUKAMOTO, MITSUO FUKUSHIMA, YOSHIHISA SHIMADA, RYU NOZAWA, KEIJIRO MATSUDA, KEIJI HASHIGUCHI, YOJIRO
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Published in
In Vivo
Background/Aim: To evaluate the benefits of the addition of oxaliplatin (OX) to fluoropyrimidine (FP)-based neoadjuvant chemoradiotherapy (CRT) for patients with locally advanced rectal cancers (LARCs). Patients and Methods: We performed retrospective analyses comparing the pathological complete response (pCR) rate, overall survival (OS), recurrenc...
FREGATTI, PIERO GIPPONI, MARCO GIACCHINO, MARIA SPARAVIGNA, MARCO DIAZ, RAQUEL FIORAVANTI, EMANUELA CORNACCHIA, CHIARA CONTE, BENEDETTA LAMBERTINI, MATTEO ZOPPOLI, GABRIELE
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In Vivo
Background/Aim: The perspective validation of a selective approach in patients undergoing breast cancer surgery was performed in order to assess whether patients as well as Health Care Workers (HCWs) were exposed to any undue risk of COVD-19 infection. Patients and Methods:From March 9th to June 9th 2020, 207 patients were phonetriaged by a dedicat...
NARVAEZ, CARLOS SCHILD, STEVEN E. RADES, DIRK
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In Vivo
Background/Aim: Some patients with unresectable or incompletely resected head-and-neck cancer (SCCHN) cannot tolerate radiochemotherapy. Alternatives are needed that are more effective than conventional radiotherapy alone. Patients and Methods: This retrospective study investigated patients irradiated for non-metastatic stage IV SCCHN who could not...
KIM, DONG-JOON CHO, SU-YEON KIM, SEUNG-UN JO, DONG-WON HWANG, HYO-IN SHIN, HYE-KYOUNG JUN, YONG-HYUN
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In Vivo
Background/Aim: Chronic cerebral hypoperfusion affects early and mature neurons in the subventricular zone (SVZ) and cerebral cortex. Herein, we investigated the effects of insulin-like growth factor-1 (IGF-1), a neurogenesis-promoting agent, on neurons in these regions in periventricular leucomalacia (PVL) model rats. Materials and Methods: Follow...
NIEDER, CARSTEN HAUKLAND, C. ELLINOR MANNSAKER, BARD YOBUTA, ROSALBA
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In Vivo
Background/Aim: The study aimed to evaluate practice changes in the time period of the early wave of the COVID-19 pandemic. Patients and Methods: This was a retrospective single institution study. We defined palliative radiotherapy (PRT) initiated before Saturday, March 14 th as pre-COVID and PRT initiated later as during-COVID (through June 30 th...
MAHARAJAN, NAGARAJAN CHO, GWANG WON JANG, CHUL HO
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In Vivo
Hearing loss is one of the major worldwide health problems that seriously affects human social and cognitive development. In the auditory system, three components outer ear, middle ear and inner ear are essential for the hearing mechanism. In the inner ear, sensory hair cells and ganglion neuronal cells are the essential supporters for hearing mech...
LIBERKO, MARIAN KOLOSTOVA, KATARINA SZABO, ARPAD GURLICH, ROBERT OLIVERIUS, MARTIN SOUMAROVA, RENATA
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In Vivo
Pancreatic ductal adenocarcinoma represents a disease with increasing incidence. Its prognosis is the worst among all malignancies despite the aggressive combined multimodal treatment across all stages. In metastatic disease, median survival is approximatelly one year. The mainstay of treatment is chemotherapy (neo/adjuvant, palliative) and in sele...
MINICHSDORFER, CHRISTOPH STEINBRECHER, OSKAR KÖLZ, MARITA SCHMID, MAXIMILIAN RADERER, MARKUS BRODOWICZ, THOMAS LAMM, WOLFGANG
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In Vivo
Background/Aim: Ewing sarcoma (ES) and osteosarcomas (OSA) are the most common bone tumor types in adolescents and young adults (AYA). Therapy management of these tumors consists of preoperative chemotherapy, operation, and postoperative chemotherapy. The aim of this study was to evaluate the efficacy and tolerability of EURAMOS-A and EURO E.W.I.N....
