Li, Haiyan Lin, Li Chong, Lei Gu, Shuge Wen, Shunhang Yu, Gang Hu, Xiaoguang Dong, Lin Zhang, Hailin Li, Changchong
...
Published in
Immunology and cell biology
Streptococcus pneumoniae is a major causative agent of pneumonia worldwide and its complex interaction with the lung epithelium has not been thoroughly characterized. In this study, we exploited both RNA-sequencing and microRNA (miRNA)-sequencing approaches to monitor the transcriptional changes in human lung alveolar epithelial cells infected by S...
Carstensen, Mikkel Christensen, Tove Stilund, Morten Møller, Holger J Petersen, Eva L Petersen, Thor
Published in
Immunology and cell biology
In multiple sclerosis (MS), the inflammation and demyelination of the central nervous system (CNS) develop in distinct ways. This makes diagnosing patients difficult, imperative to initiating early and proper treatment. Several common features exist, among them a profound infiltration of monocytes into the CNS mediating demyelination and tissue des...
Kapetanovic, Ronan Afroz, Syeda Farhana Ramnath, Divya Lawrence, Grace MEP Okada, Takashi Curson, James EB de Bruin, Jost Fairlie, David P Schroder, Kate St John, Justin C
...
Published in
Immunology and Cell Biology
Here, we demonstrate that lipopolysaccharide (LPS) acts via a Tlr4–MyD88–Drp1 axis to initiate mitochondrial fission and selective inflammatory responses in macrophages. We also show that LPS promotes sequential dynamin‐related protein 1 (Drp1) serine phosphorylation (S635) and dephosphorylation (S656), with the latter modification requiring the ad...
James, Kylie R King, Hamish W
Published in
Immunology and Cell Biology
Chen et al. describe how B‐cell clones observed in the gut of many different individuals (recurrent or “public” clonotypes) are shaped by the combined influences of common microbial antigens and underlying genomic recombination biases.
Eberl, Matthias
Published in
Immunology and Cell Biology
Sensing of self and non‐self phosphoantigens by human Vγ9/Vδ2 T cells in the context of the butyrophilin family members BTN2A1 and BTN3A1.
Chenoweth, Alicia M. Wines, Bruce D. Anania, Jessica Hogarth, P.
The human fragment crystallizable (Fc)gamma receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are...
Horton, Miles B Hawkins, Edwin D Heinzel, Susanne Hodgkin, Philip D
Published in
Immunology and Cell Biology
We argue that the development of adaptive immunity resulted from the adoption, reuse and repurposing of an ancient, autonomous cellular program. Signature features of this ancient program can be seen exploited in many arms of the immune response.
Gu, Lingwen Lin, Jing Wang, Qian Li, Cui Peng, Xudong Fan, Yiqun Lu, Chunli Lin, Hao Niu, Yawen Zhu, Guoqiang
...
Published in
Immunology and cell biology
Dimethyl itaconate (DI) is a membrane-permeable itaconate derivative with anti-inflammatory functions. However, the anti-inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI against fungal keratitis and assessed the role of NF-E2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) si...
Obeidy, Peyman Ju, Lining A Oehlers, Stefan H Zulkhernain, Nursafwana S Lee, Quintin Galeano Niño, Jorge L Kwan, Rain Yq Tikoo, Shweta Cavanagh, Lois L Mrass, Paulus
...
Published in
Immunology and cell biology
T lymphocytes utilize amoeboid migration to navigate effectively within complex microenvironments. The precise rearrangement of the actin cytoskeleton required for cellular forward propulsion is mediated by actin regulators, including the actin-related protein 2/3 (Arp2/3) complex, a macromolecular machine that nucleates branched actin filaments at...
Davis, Samantha K Selva, Kevin J Kent, Stephen J Chung, Amy W
Published in
Immunology and Cell Biology
The role of mucosal immunoglobulin A (IgA) in infection (e.g. neutralization) has been extensively investigated; by contrast, serum IgA is poorly understood. Crosslinking of serum IgA with fragment crystallizable alpha receptor I (FcαRI) can activate immune cells (e.g. phagocytosis, antibody‐dependent cellular cytotoxicity, reactive oxygen species)...
