Published in Immunology and Cell Biology
Coronavirus disease 2019 (COVID‐19) results from a virus making an interspecies leap that tests genetic resistance to viral disease, like most of the great plagues sculpting human history. Here I set out known unknowns for tackling COVID‐19, taking advantage of progress understanding how viral disease is countered by fundamentally different genetic...
Published in Immunology and cell biology
Ex vivo mammary explant systems are an excellent model to study interactions between epithelium and stromal cell types because they contain physiologically relevant heterotypic interactions in the background of genetically diverse patients. The intact human mammary tissue, termed patient-derived explant (PDE), can be used to investigate cellular re...
Published in Immunology and cell biology
Streptococcus pneumoniae is a major causative agent of pneumonia worldwide and its complex interaction with the lung epithelium has not been thoroughly characterized. In this study, we exploited both RNA-sequencing and microRNA (miRNA)-sequencing approaches to monitor the transcriptional changes in human lung alveolar epithelial cells infected by S...
Published in Immunology and cell biology
Marginal zone (MZ) B cells are innate-like B cells that produce polyreactive antibodies with an affinity for microbial molecular patterns and carbohydrate ligands. MZ B cells have been shown to be important in mediating immunity to various bacteria including Streptococcus pneumoniae and are also implicated in inflammatory syndromes including lupus ...
Published in Immunology and Cell Biology
In this study, we showed that induction of inflammation in the peritoneal cavity by Toll‐like receptor 2 (TLR2) agonists induces chemokine production with very high levels of the CCR2 ligands CCL2 and CCL7. Natural killer (NK) cells are recruited to the peritoneum after TLR2‐induced inflammation in a CCR2‐dependent manner, but do not acquire an act...
Published in Immunology and cell biology
In multiple sclerosis (MS), the inflammation and demyelination of the central nervous system (CNS) develop in distinct ways. This makes diagnosing patients difficult, imperative to initiating early and proper treatment. Several common features exist, among them a profound infiltration of monocytes into the CNS mediating demyelination and tissue des...
Published in Immunology and cell biology
Sequencing the first human genome in 2003 took 15 years and cost $2.7 billion. Advances in sequencing technologies have since decreased costs to the point where it is now feasible to resequence a whole human genome for $1000 in a single day. These advances have allowed the generation of huge volumes of high-quality human sequence data used to const...
Published in Immunology and Cell Biology
Here, we demonstrate that lipopolysaccharide (LPS) acts via a Tlr4–MyD88–Drp1 axis to initiate mitochondrial fission and selective inflammatory responses in macrophages. We also show that LPS promotes sequential dynamin‐related protein 1 (Drp1) serine phosphorylation (S635) and dephosphorylation (S656), with the latter modification requiring the ad...
Published in Immunology and Cell Biology
Chen et al. describe how B‐cell clones observed in the gut of many different individuals (recurrent or “public” clonotypes) are shaped by the combined influences of common microbial antigens and underlying genomic recombination biases.
Published in Immunology and Cell Biology
Sensing of self and non‐self phosphoantigens by human Vγ9/Vδ2 T cells in the context of the butyrophilin family members BTN2A1 and BTN3A1.
