Leno-Durán, Ester Ng, Sze-Ling Strominger, Jack L
Published in
Immunology
Humanized double transgenic mice express both HLA-DR15 (the MHC gene linked to MS) and the TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85-99 presented by HLA-DR15), yet they fail to develop autoimmune encephalomyelitis quickly, although 5-10% develop disease at 12 months. These mice were found to express large numbers of IL-10 ...
Perryman, Matthew Milling, Simon
Published in
Immunology
2020 was a year unlike any other for Immunology. Through the SARS-CoV-2 pandemic, with fantastic support from the global immunology community, we worked together to reach new heights. Here, we look back at some of the highlights for Immunology in a challenging and memorable year. © 2020 John Wiley & Sons Ltd.
Toor, Salman M. Saleh, Reem Sasidharan Nair, Varun Taha, Rowaida Z. Elkord, Eyad
Published in
Immunology
This review focuses on the multi‐faceted roles of T cells in COVID‐19 pathogenesis and rationalizes their significance in eliciting appropriate antiviral immune responses in COVID‐19 patients and unexposed individuals. In addition, wesummarize the potential therapeutic approaches related to T cells to treat COVID‐19 patients.
Kalm, Frida Mansouri, Ladan Russom, Aman Lundahl, Joachim Nopp, Anna
Published in
Immunology
Basophils are known for their role in allergic inflammation, which makes them suitable targets in allergy diagnostics such as the basophil activation test (BAT) and the microfluidic immunoaffinity basophil activation test (miBAT). Beside their role in allergy, basophils have an immune modulatory role in both innate immunity and adaptive immunity. T...
Nizami, Sohaib Arunasalam, Kanisa Green, Jack Cook, James Lawrence, Catherine B Zarganes-Tzitzikas, Tryfon Davis, John B Di Daniel, Elena Brough, David
Published in
Immunology
Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro-inflammatory cytokine interleukin(IL)-1β. Here, primarily using an in vitro inflammasome ASC speck assay, and an in vivo model o...
Calonga-Solís, Verónica Amorim, Leonardo M Farias, Ticiana D J Petzl-Erler, Maria Luiza Malheiros, Danielle Augusto, Danillo G
Published in
Immunology
Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of pathogenic autoantibodies against desmoglein 1, a component of intercellular desmosome junctions. PF occurs sporadically across the globe and is endemic in some Brazilian regions. Because PF is a B-cell-mediated disease, we aimed to study the impact o...
Yiu, Hao H Schoettle, Louis N Garcia-Neuer, Marlene Blattman, Joseph N Johnson, Philip L F
Published in
Immunology
Within each individual, the adaptive immune system generates a repertoire of cells expressing receptors capable of recognizing diverse potential pathogens. The theoretical diversity of the T-cell receptor (TCR) repertoire exceeds the actual size of the T-cell population in an individual by several orders of magnitude - making the observation of ide...
Baxter, Matthew Ray, David W
Published in
Immunology
Circadian clocks are a common feature of life on our planet, allowing physiology and behaviour to be adapted to recurrent environmental fluctuation. There is now compelling evidence that disturbance of circadian coherence can severely undermine mental and physical health, as well as exacerbate pre-existing pathology. Common molecular design princip...
Downton, Polly Early, James O Gibbs, Julie E
Published in
Immunology
The circadian clock provides organisms with the ability to track time of day, allowing them to predict and respond to cyclical changes in the external environment. In mammals this clock consists of multiple auto-regulatory feedback loops generated by a network of circadian clock proteins. This network provides the fundamental basis for rhythms in b...
Toufiq, Mohammed Roelands, Jessica Alfaki, Mohamed Syed Ahamed Kabeer, Basirudeen Saadaoui, Marwa Lakshmanan, Arun Prasath Bangarusamy, Dhinoth Kumar Murugesan, Selvasankar Bedognetti, Davide Hendrickx, Wouter
...
Published in
Immunology
According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. Here we explored this interpretation gap and identified possible directions for future research...
