Published in Immunology
Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study the effects of ablation of langerin+ cells on healing of a full-thickness excision wound were investigated using the langerin-DTR d...
Published in Immunology
The liver is a front‐line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream through a highly specialized network of liver‐adapted immune cells. Mapping the immune resident compartment in the liver has been challenging because it requires multimodal single‐cell de...
Published in Immunology
The respiratory epithelium provides a highly effective barrier acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens.
Published in Immunology
The immune system in skin is established early during development. Throughout development it continues to expand and diversify.
Published in Immunology
Macrophage glycolysis conversion mediates histone hyperacetylation. Histone hyperacetylation could enhance IL‐1β production. Glycolytic metabolism regulates IL‐1β expression by increasing histone acetylation levels in LPS/IFN‐γ‐stimulated macrophages.
Published in Immunology
The International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb) connects expert‐curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. Pharmacological databases are a vital resource to researchers through providing accurate information o...
Published in Immunology
Signalling lymphocyte activation molecule family member 9 (SLAMF9) is a cell surface receptor found on specialized subsets of mononuclear phagocytes. Deficiencies in SLAMF9 expression lead to altered pro‐inflammatory cytokine production in human cells and reduced capacity to clear Salmonella infection in mice.
Published in Immunology
Among various solid tumours, gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Expansion into the peritoneal cavity, which results from dissemination of diffuse cancer cells, is the main cause of mortality in gastric adenocarcinoma patients. Therefore, investigation of putative biomarkers involved in metastasis is...
Published in Immunology
TGF‐ β is a crucial cytokine in regulation of the immune system, especially at barrier sites. Many cell types can produce TGF‐ β , but always as an inactive complex that requires activating to be functional. This review highlights vital pathways that activate TGF‐ β in the intestine, lung and skin, with a focus on how integrins control TGF‐ β activ...
Published in Immunology
Recent studies have identified new T‐cell‐intrinsic roles for the IFITM family in T helper differentiation and atopic and inflammatory disease, which are independent of their functions in cellular resistance to viral infection.
