Wu, Liang Ehlin-Henriksson, Barbro Zhou, Xiaoying Zhu, Hong Ernberg, Ingemar Kis, Lorand L Klein, George
Published in
Immunology
Diffuse large B-cell lymphoma (DLBCL), the most common type of malignant lymphoma, accounts for 30% of adult non-Hodgkin lymphomas. Epstein-Barr virus (EBV) -positive DLBCL of the elderly is a newly recognized subtype that accounts for 8-10% of DLBCLs in Asian countries, but is less common in Western populations. Five DLBCL-derived cell lines were ...
McDermott, Andrew J Tumey, Tyler A Huang, Mingwei Hull, Christina M Klein, Bruce S
Published in
Immunology
Pulmonary challenge with the ubiquitous fungus Cryptococcus neoformans results in allergic airway inflammation (AAI) characterized by robust recruitment of eosinophils and T cells producing type 2 cytokines to the lungs. Previous studies have demonstrated a critical role for Nuclear Factor Kappa B (NF-κB) activation within lung epithelial cells (LE...
Webb, Louise M C Linterman, Michelle A
Published in
Immunology
T follicular helper (Tfh) cells are a distinct type of CD4+ T cell specialized in providing help to B cells during the germinal centre (GC) reaction. As such, they are critical determinants of the quality of an antibody response following antigen challenge. Excessive production of Tfh cells can result in autoimmunity whereas too few can result in i...
Wallace, Jennillee Lutgen, Victoria Avasarala, Sreedevi St Croix, Brad Winn, Robert A Al-Harthi, Lena
Published in
Immunology
The variation of macrophage functions suggests the involvement of multiple signalling pathways in fine tuning their differentiation. Macrophages that originate from monocytes in the blood migrate to tissue in response to homeostatic or 'danger' signals and undergo substantial morphological and functional modifications to meet the needs of the domin...
Passos, Geraldo A Speck-Hernandez, Cesar A Assis, Amanda F Mendes-da-Cruz, Daniella A
Published in
Immunology
Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, and was cloned and sequenced. Its importance goes beyond its abstract link with human autoimmune disease. Aire identification opened new perspectives to better understand the molecular basis of central tolerance...
Yang, Yi-Fei Zhou, Yi-Dan Hu, Jia-Chen Luo, Feng-Ling Xie, Yan Shen, Yan-Ying Bian, Wen-Xiu Yin, Zhi-Nan Li, Hong-Liang Zhang, Xiao-Lian
...
Published in
Immunology
Human ficolin-2 (FCN-2) and mouse ficolin-A (FCN-A, a ficolin-2-like molecule in mouse) are activators of the lectin complement pathway, present in normal plasma and usually associated with infectious diseases, but little is known about the role of FCN-A/2 in inflammatory bowel disease (IBD). In our present study, we found that patients with IBD ex...
Wei, Yuzhen Yu, Kunwu Wei, Hui Su, Xin Zhu, Ruirui Shi, Huairui Sun, Haitao Luo, Quan Xu, Wenbin Xiao, Junhui
...
Published in
Immunology
Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4+ T cells with suppressive activity has been established. This study aimed to investigate the frequency and function of circulating CD4+ CD25+ GARP+ ...
Mao, Lie Hou, Hongyan Wu, Shiji Zhou, Yu Wang, Juan Yu, Jing Wu, Xiaohui Lu, Yanfang Mao, Liyan Bosco, Munyemana Jean
...
Published in
Immunology
B-lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T-cell-dependent, and CD4+ T-cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4+ T cells in SLE is largely unknown. T-cell immunoglobulin and ITIM domain (TIGIT) is a new inhibitory receptor preferentially expressed on activated CD4+...
Meng, Ziyu Wang, Jingya Yuan, Yifang Cao, Guangchao Fan, Shuobing Gao, Chao Wang, Li Li, Zheng Wu, Xiaoli Wu, Zhenzhou
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Published in
Immunology
Hepatitis B virus surface antigen (HBsAg) carriers are highly susceptible to liver injury triggered by environmental biochemical stimulation. Previously, we have reported an inverse correlation between γδ T cells and liver damage in patients with hepatitis B virus (HBV). However, whether γδ T cells play a role in regulating the hypersensitivity of ...
Lapenna, Antonio Omar, Ibrahim Berger, Michael
Published in
Immunology
We report a new mouse strain with a single point mutation in the type 2 transporter associated with antigen processing (TAP2). This strain randomly arose in one of our C57BL/6J mouse colonies and was initially discovered because of the lack of CD8+ T cells in the periphery. Following our observation, we subsequently revealed a lack of cell surface ...
