Shaw, Tovah N Haley, Michael J Dookie, Rebecca S Godfrey, Jenna J Cheeseman, Antonn J Strangward, Patrick Zeef, Leo A H Villegas-Mendez, Ana Couper, Kevin N
Published in
Immunology
Experimental cerebral malaria (ECM) is a severe complication of Plasmodium berghei ANKA (PbA) infection in mice, characterised by CD8+ T cell accumulation within the brain. Whilst the dynamics of CD8+ T cell activation and migration during extant primary PbA infection have been extensively researched, the fate of the parasite-specific CD8+ T cells ...
Teijeira Crespo, Alicia Burnell, Stephanie Capitani, Lorenzo Bayliss, Rebecca Moses, Elise Mason, Georgina H Davies, James A Godkin, Andrew J Gallimore, Awen M Parker, Alan L
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Published in
Immunology
Oncolytic viruses possess the ability to infect, replicate and lyse malignantly transformed tumour cells. This oncolytic activity amplifies the therapeutic advantage and induces a form of immunogenic cell death, characterized by increased CD8 + T-cell infiltration into the tumour microenvironment. This important feature of oncolytic viruses can res...
Lennon, Charlotte S Cao, Huan Hall, Andrew M Vickers, Mark A Barker, Robert N
Published in
Immunology
Non-immune cells are increasingly recognized as important in regulating immunity, but the role of red blood cells (RBC) remains relatively unexplored, despite their abundance in the circulation and a cell surface rich in potential ligands. Here, we determine whether RBC influence the activation state of human B cells. Separation of RBC from periphe...
Riera Romo, Mario
Published in
Immunology
Regulated or programmed cell death plays a critical role in the development and tissue organization and function. In addition, it is intrinsically connected with immunity and host defence. An increasing cellular and molecular findings cause a change in the concept of cell death, revealing an expanding network of regulated cell death modalities and ...
Jimenez-Duran, Gisela Triantafilou, Martha
Published in
Immunology
Nucleotide-binding domain and leucine-rich repeat receptor (NLR)-mediated inflammasome activation is important in host response to microbes, danger-associated molecular patterns (DAMPs) and metabolic disease. Some NLRs have been shown to interact with distinct cell metabolic pathways and cause negative regulation, tumorigenesis and autoimmune disor...
Ke, Cuncun Ma, Yonghe Pan, Dengke Wan, Zihui Feng, Tao Yu, Dawei Liu, Xiaojuan Wang, Haitao Du, Minjie Huang, Linhua
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Published in
Immunology
In contrast to humans or rabbits, in which maternal IgG is transmitted to offspring prenatally via the placenta or the yolk sac, large domestic animals such as pigs, cows and sheep transmit IgG exclusively through colostrum feeding after delivery. The extremely high IgG content in colostrum is absorbed by newborns via the small intestine. Although ...
Patel, Amit A Ginhoux, Florent Yona, Simon
Published in
Immunology
Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and help orchestrate the immune response. This family of cells can be separated by their nuclear morphology into mononuclear and polymorphonuclear phagocytes. The generation of these cells in the bone marrow, to the blood and finally into tissues is a tightly re...
Leno-Durán, Ester Ng, Sze-Ling Strominger, Jack L
Published in
Immunology
Humanized double transgenic mice express both HLA-DR15 (the MHC gene linked to MS) and TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85-99 presented by HLA-DR15), yet they fail to develop autoimmune encephalomyelitis quickly, although 5-10% develop disease at 12 months. These mice were found to express large numbers of IL-10-secr...
Worrell, Julie C MacLeod, Megan K L
Published in
Immunology
Communication between stromal and immune cells is essential to maintain tissue homeostasis, mount an effective immune response and promote tissue repair. This 'crosstalk' occurs in both the steady state and following a variety of insults, for example, in response to local injury, at sites of infection or cancer. What do we mean by crosstalk between...
Sui, Hongyan Chen, Qian Imamichi, Tomozumi
Published in
Immunology
We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the nucleus into the cytoplasm and then predominately induces interferon lambda1 (IFN-λ1) rather than IFN-alpha or IFN-beta, through a STING-dependent signalling pathway. ...
