Jiang, Lei Zhao, Xingwang Li, Yilin Hu, Yajie Sun, Yu Liu, Shengde Zhang, Zizhen Li, Yanyan Feng, Xujiao Yuan, Jiajia
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IUBMB life
Combination therapy with anti-HER2 agents and immunotherapy has demonstrated significant clinical benefits in gastric cancer (GC), but the underlying mechanism remains unclear. In this study, we used multiplex immunohistochemistry to assess the changes of the tumor microenvironment in 47 advanced GC patients receiving anti-HER2 therapy. Additionall...
Mastronikolis, Nicholas S Kyrodimos, Efthymios Piperigkou, Zoi Spyropoulou, Despoina Delides, Alexander Giotakis, Evangelos Alexopoulou, Miranda Bakalis, Nick A Karamanos, Nikos K
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IUBMB life
Oral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation o...
Dinh, Nhu Bonnefoy, Nathalie
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IUBMB life
Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial research. The organism resembles human cells in terms of mitochondrial inheritance, mitochondrial transport, sugar metabolism, mitogenome structure and dependence of viability on the mitogenome (the petite-negative phenotype). Transcriptions of these genomes produce ...
Choudhary, Shweta Nehul, Sanketkumar Singh, Ankur Panda, Prasan Kumar Kumar, Pravindra Sharma, Gaurav Kumar Tomar, Shailly
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IUBMB life
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be over, but its variants continue to emerge, and patients with mild symptoms having long COVID is still under investigation. SARS-CoV-2 infection leading to elevated cytokine levels and suppressed immune responses set off cy...
Ertem, Tuğba Uysal, Onur
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IUBMB life
The aim of this study was to develop an alternative treatment method for neurodegenerative diseases with dopaminergic neuron loss such as Parkinson's disease by differentiating cells obtained from human olfactory mucosa-derived neural stem cells (hOM-NSCs) with neurotrophic agents in vitro. hOM-NSCs were isolated and subjected to immunophenotypic a...
Yu, Tianwei Wang, Hongwei Guo, Rong Liu, Jianzhong Tian, Lili Guga, Suri Li, Weixin Zhao, Huiying Suo, Feiya Yang, Hao
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IUBMB life
Our hospital admitted a patient who had difficulty in coagulation even after blood replacement, and the patient had abused caffeine sodium benzoate (CSB) for more than 20 years. Hence, we aimed to explore whether CSB may cause dysfunction in vascular endothelial cells and its possible mechanism. Low, medium, and high concentrations of serum of long...
Newell, Stella van der Watt, Pauline J Leaner, Virna D
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IUBMB life
Systemic modalities are crucial in the management of disseminated malignancies and liquid tumours. However, patient responses and tolerability to treatment are generally poor and those that enter remission often return with refractory disease. Combination therapies provide a methodology to overcome chemoresistance mechanisms and address dose-limiti...
Das, Gourab Das, Troyee Parida, Sibun Ghosh, Zhumur
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IUBMB life
Long non-coding RNAs (lncRNAs) play a significant role in various biological processes. Hence, it is utmost important to elucidate their functions in order to understand the molecular mechanism of a complex biological system. This versatile RNA molecule has diverse modes of interaction, one of which constitutes lncRNA-mRNA interaction. Hence, ident...
Bui, Thi Hoang Diu Labedzka-Dmoch, Karolina
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IUBMB life
The mitochondrial retrograde signaling (RTG) pathway of communication from mitochondria to the nucleus was first studied in yeast Saccharomyces cerevisiae. It rewires cellular metabolism according to the mitochondrial state by reprogramming nuclear gene expression in response to mitochondrial triggers. The main players involved in retrograde signal...
Golik, Pawel
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IUBMB life
Yeast mitochondrial genes are expressed as polycistronic transcription units that contain RNAs from different classes and show great evolutionary variability. The promoters are simple, and transcriptional control is rudimentary. Posttranscriptional mechanisms involving RNA maturation, stability, and degradation are thus the main force shaping the t...
