Miyaoka, Yoshitaka Okada, Tomonari Tomiyama, Hirofumi Morikawa, Atsuko Rinno, Sho Kato, Miho Tsujimoto, Ryuji Suzuki, Rie China, Rieko Nagai, Miho
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Published in
Hypertension research : official journal of the Japanese Society of Hypertension
Although central hemodynamics are known to be closely associated with microvascular damage, their association with lesions in the small renal arteries has not yet been fully clarified. We focused on arterioles in renal biopsy specimens and analyzed whether their structural changes were associated with noninvasive vascular function parameters, inclu...
Murakami, Tomoaki Horibata, Yoko Tateno, Shigeru Kawasoe, Yasutaka Niwa, Koichiro
Published in
Hypertension research : official journal of the Japanese Society of Hypertension
Many studies have reported that adults with congenital heart disease suffer from hypertension and cardiovascular disease even at younger ages. Therefore, we analyzed early vascular aging, which is defined as pulse wave velocity values higher than the 95th percentile for age and sex, and clarified the relationship between early vascular aging and ma...
Zicha, Josef Behuliak, Michal Vavřínová, Anna Dobešová, Zdenka Kuneš, Jaroslav Rauchová, Hana Vaněčková, Ivana
Published in
Hypertension research : official journal of the Japanese Society of Hypertension
Salt hypertensive Dahl rats are characterized by sympathoexcitation and relative NO deficiency. We tested the hypothesis that the increased blood pressure (BP) response to fasudil in salt hypertensive Dahl rats is due to augmented calcium sensitization in the salt-sensitive strain and/or due to their decreased baroreflex efficiency. BP reduction af...
Melgarejo, Jesus D. Maestre, Gladys E. Mena, Luis J. Lee, Joseph H. Petitto, Michele Chávez, Carlos A. Calmon, Gustavo Silva, Egle Thijs, Lutgarde Al-Aswad, Lama A.
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Published in
Hypertension research : official journal of the Japanese Society of Hypertension
Hypoperfusion of the optic nerve might be involved in the pathogenesis of normal-tension glaucomatous optic neuropathy (GON). Mean arterial pressure (MAP) drives ocular perfusion, but no previous studies have addressed the risk of GON in relation to blood pressure (BP) variability, independent of BP level. In a cross-sectional study, 93 residents o...
Saito, Jumpei Mito, Asako Yakuwa, Naho Kaneko, Kayoko Kawasaki, Hiroyo Suzuki, Tomo Yamatani, Akimasa Sago, Haruhiko Murashima, Atsuko
Published in
Hypertension Research
Deshpande, Juilee S. Sundrani, Deepali P. Sahay, Akriti S. Gupte, Sanjay A. Joshi, Sadhana R.
Published in
Hypertension Research
Preeclampsia is a multisystem, multiorgan hypertensive disorder of pregnancy responsible for maternal and perinatal morbidity and mortality in low- and middle-income countries. The classic diagnostic features hold less specificity for preeclampsia and its associated adverse outcomes, suggesting a need for specific and reliable biomarkers for the ea...
Yu, Yang Xu, Li-Shi Wu, Yue Su, Fan-Fan Zhou, Xiao-Mian Xu, Cheng
Published in
Hypertension Research
We investigated the antihypertensive effects of maximakinin (MK) on spontaneously hypertensive rats (SHRs). The effects of MK on arterial blood pressure in SHRs were observed, and flow cytometry and 4,5-diaminofluorescein-2 staining were used to examine MK-induced nitric oxide (NO) release in human umbilical vein endothelial cells (HUVECs). Western...
Ohkuchi, Akihide Masuyama, Hisashi Yamamoto, Tatsuo Kikuchi, Takashi Taguchi, Naoko Wolf, Cyrill Saito, Shigeru
Published in
Hypertension Research
The PRediction of short-term Outcomes in preGNant wOmen with Suspected preeclampsIa Study (PROGNOSIS) Asia validated the use of the soluble fms-like tyrosine 1/placental growth factor (sFlt-1/PlGF) ratio cutoff value of ≤38 to rule out the occurrence of preeclampsia in the short term in Asian women. We assessed the economic impact of the introducti...
Zhang, Zhuxian Zhou, Chun Liu, Mengyi Zhang, Yuanyuan Li, Huan He, Panpan Nie, Jing Liang, Min Liu, Chengzhang Song, Yun
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Published in
Hypertension Research
We aimed to investigate the association between neutrophil counts and first stroke and examine possible effect modifiers among treated hypertensive adults. This is a post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT). A total of 11,878 hypertensive adults with data on neutrophil counts at baseline were included in the current st...
Hirata, Takumi Kogure, Mana Tsuchiya, Naho Miyagawa, Ken Narita, Akira Nochioka, Kotaro Uruno, Akira Obara, Taku Nakamura, Tomohiro Nakaya, Naoki
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Published in
Hypertension Research
Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese pop...
