The pivotal role of the angiotensin-II-NF-κB axis in the development of COVID-19 pathophysiology.
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Our previous study showed that the morning systolic blood pressure target should be
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Hypertension is an important factor affecting the health of older adults. Antihypertensives can reduce stroke, cardiovascular events, and mortality in older hypertensive patients. Blood pressure management is difficult in older adults since geriatric syndromes such as frailty and comorbidities often coexist with hypertension. Recent guidelines prop...
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Lifetime risk is an informative estimate to motivate people to change lifestyle behaviors, especially from a younger age, in public health education. The impact of the combination of hypertension and diabetes on the lifetime risk of cardiovascular mortality has not been investigated in Asian populations. A pooled analysis of individual data from ni...
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Mineralocorticoid receptor (MR) blockers are very beneficial for patients with hypertension and primary aldosteronism (PA). We investigated the efficacy and safety of a newly available nonsteroidal MR blocker, esaxerenone, in Japanese patients with hypertension and PA. A multicenter, open-label study was conducted in Japan between October 2016 and ...
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Published in Hypertension research : official journal of the Japanese Society of Hypertension
The aim of our cross-sectional study was to evaluate skin microvascular alterations in patients with hypertension secondary to primary aldosteronism (PA) and in subjects with essential hypertension (EH). Skin microcirculation was detected by nailfold videocapillaroscopy (NVC) and laser Doppler perfusion imaging (LDPI), both noninvasive techniques f...
Published in Hypertension research : official journal of the Japanese Society of Hypertension
Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline d...
Published in Hypertension research : official journal of the Japanese Society of Hypertension