Zhang, Suqin Shi, Yanmei Dong, Pingping
Published in
Human immunology
The aim of this study was to investigate the role of ubiquitin-specific peptidase 8 (USP8) in human trophoblast cells and its molecular mechanism. Based on the GSE30186 dataset, USP8 was identified as a downregulated gene in pre-eclampsia (PE). Analysis of clinical samples also revealed that USP8 expression at both the mRNA and protein levels in pl...
Arshad, Maria Noor, Nabeel Iqbal, Zunair Jaleel, Hadiqa
Published in
Human immunology
Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine that is involved in the pathogenesis of various inflammatory disorders including rheumatoid arthritis. TNF-alpha receptor I (TNFR1a) is one of the receptors TNFa binds with for its activation. Any variation in this receptor might affect the role of TNFa in successive events. Amino acid ...
Moavro, Damián E Andrini, Laura Iribarne, Ailén Colaci, Pablo García, Marcela
Published in
Human immunology
Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA-G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA-G expression in the bladder TC in a public hospital in Argentina linking its...
Alves, Cinthia C Arns, Thaís Oliveira, Maria L Moreau, Philippe Antunes, Dinler A Castelli, Erick C Mendes-Junior, Celso T Giuliatti, Silvana Donadi, Eduardo A
Published in
Human immunology
We took advantage of the increasingly evolving approaches for in silico studies concerning protein structures, protein molecular dynamics (MD), protein-protein and protein-DNA docking to evaluate: (i) the structure and MD characteristics of the HLA-G well-recognized isoforms, (ii) the impact of missense mutations at HLA-G receptor genes (LILRB1/2),...
Rohn, Hana Schramm, Sabine Pansikaki, Krystallenia Jansen, Sarah Hendriks, Celina Platte, Maximilian Konik, Margarethe J Dolff, Sebastian Wilde, Benjamin Kordelas, Lambros
...
Published in
Human immunology
The immunosuppressive non-classical human leukocyte antigen-G (HLA-G) can elicits pro-viral activities by down-modulating immune responses. We analysed soluble forms of HLA-G, IL-6 and IL-10 as well as on immune effector cell expression of HLA-G and its cognate ILT-2 receptor in peripheral blood obtained from hospitalised and convalescent COVID-19 ...
Ajith, Ashwin Mamouni, Kenza Musa, Abu Horuzsko, Daniel D Gani, Imran Mulloy, Laura L Horuzsko, Anatolij
Published in
Human immunology
Despite the growing interest in the role of regulatory B cells (Bregs) in autoimmunity, their distinct role and function in kidney transplant outcomes remain elusive. Here, we retrospectively analyzed the proportion of Bregs, transitional Bregs (tBregs) and memory Bregs (mBregs) and their capacity to produce IL-10 in non-rejected (NR) versus reject...
Beltrami, Silvia Rizzo, Sabrina Strazzabosco, Giovanni Gentili, Valentina Alogna, Andrea Narducci, Marco Bortolotti, Daria Schiuma, Giovanna Rizzo, Roberta
Published in
Human immunology
Human Leukocyte Antigens (HLA) are classified in three different classes I, II and III, and represent the key mediators of immune responses, self-tolerance development and pathogen recognition. Among them, non-classical subtypes (HLA-Ib), e.g. HLA-E and HLA-G, are characterize by tolerogenic functions that are often exploited by viruses to evade th...
Xie, Yunkai Gao, Yixuan Liu, Wei Zou, Yonghui Li, Changzhong
Published in
Human immunology
Adenomyosis is a benign gynaecological disease caused by the growth of endometrial tissue in the myometrium that affects approximately 30 % of child-bearing-age women. We evaluated the levels of soluble human leukocyte antigen G (sHLA-G) in the serum of patients with adenomyosis before and after treatment. Serum samples of 34 patients with adenomyo...
Venet, Fabienne Schilling, Jeremy Cazalis, Marie-Angélique Demaret, Julie Poujol, Fanny Girardot, Thibaut Rouget, Christelle Pachot, Alexandre Lepape, Alain Friggeri, Arnaud
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Published in
Human immunology
Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study, we identified LILRB2 as an up...
Parsonidis, Panagiotis Mamagkaki, Alexandra Papasotiriou, Ioannis
Published in
Human immunology
Patients with advanced stage breast cancer need novel therapies. New potential treatments have been developed, such as adoptive cellular therapies and alternative cell-free immunotherapies. The goal of this study was to assess the cytotoxicity of three of the patient-derived immune components, CTLs, NK cells and NK-derived EVs, and evaluate the pot...
