Aboussahoud, Wedad S Smith, Helen Stevens, Adam Wangsaputra, Ivan Hunter, Helen R Kimber, Susan J Seif, Mourad W Brison, Daniel R
Published in
Human Reproduction (Oxford, England)
STUDY QUESTION Is the innate immunity system active in early human embryo development? SUMMARY ANSWER The pattern recognition receptors and innate immunity Toll-like receptor (TLR) genes are widely expressed in preimplantation human embryos and the pathway appears to be active in response to TLR ligands. WHAT IS KNOWN ALREADY Early human embryos ar...
Rahban, Rita Rehfeld, Anders Schiffer, Christian Brenker, Christoph Egeberg Palme, Dorte Louise Wang, Tao Lorenz, Johannes Almstrup, Kristian Skakkebaek, Niels E Strünker, Timo
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Published in
Human Reproduction (Oxford, England)
STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro . WHAT IS KNOWN ALREADY In human sperm, CatSper translates changes of the chemi...
Atwoli, Lukoye Baqui, Abdullah H Benfield, Thomas Bosurgi, Raffaella Godlee, Fiona Hancocks, Stephen Horton, Richard Laybourn-Langton, Laurie Monteiro, Carlos Augusto Norman, Ian
...
Published in
Human Reproduction (Oxford, England)
Ahn, Jungho Yoon, Min-Ji Hong, Seon-Hwa Cha, Hwijae Lee, Danbi Koo, Hwa Seon Ko, Ji-Eun Lee, Jungseub Oh, Soojung Jeon, Noo Li
...
Published in
Human Reproduction (Oxford, England)
STUDY QUESTION Can we reconstitute physiologically relevant 3-dimensional (3D) microengineered endometrium in-vitro model? SUMMARY ANSWER Our representative microengineered vascularised endometrium on-a-chip closely recapitulates the endometrial microenvironment that consists of three distinct layers including epithelial cells, stromal fibroblasts ...
Bentov, Y Beharier, O Moav-Zafrir, A Kabessa, M Godin, M Greenfield, C S Ketzinel-Gilad, M Ash Broder, E Holzer, H E G Wolf, D
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Published in
Human Reproduction (Oxford, England)
STUDY QUESTION Does the immune response to coronavirus disease 2019 (COVID-19) infection or the BNT162b2 mRNA vaccine involve the ovarian follicle, and does it affect its function? SUMMARY ANSWER We were able to demonstrate anti-severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) IgG in follicular fluid (FF) from both infected and vaccinat...
Hentschke, M Dornelles, V Campo Telöken, I. Badalott Kira, A Frar Colombo, T Farinati, D Petracco, A Badalotti, M
Published in
Human Reproduction (Oxford, England)
Study question How has the COVID–19 pandemic affected the psychological aspects of men and women undergoing reproductive treatments? Summary answer The women were more emotionally affected due to the COVID–19 pandemic than men, especially increasing anxiety and fear of not achieving pregnancy. What is known already COVID–19 pandemic required change...
Vagios, S Sacha, C R Hammer, K C Fitz, V W Dimitriadis, I Souter, I Bormann, C L
Published in
Human Reproduction (Oxford, England)
Study question How have the coronavirus 2019 (COVID–19)-driven changes in semen collection protocols, from on-site to at-home collection, impacted intrauterine insemination (IUI) cycle outcomes? Summary answer Our data suggest that at-home semen collection within 2 hours of processing does not negatively impact semen parameters and IUI pregnancy ou...
Henarejo. Castillo, I Sebastian-Leon, P Devesa-Peiro, A Aleman, A Diaz-Gimeno, P
Published in
Human Reproduction (Oxford, England)
Study question Could the transcriptomic and functional landscape of the window of implantation be compromised by SARS-COV–2 infection? Summary answer Some of the main genes and pathways involved in the window of implantation are affected in blood of COVID–19 patients and receptivity could be affected. What is known already There is a concern whethe...
Mataro, D Cuevas-Saiz, I Castilla, J A Dominguez, J A Prados, N Buch, B González López de Bustamante, B Prados, F J Ruiz-Jorro, M Gomez, J L
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Published in
Human Reproduction (Oxford, England)
Study question What is the SARS-CoV-2 positivity rate following the Spanish Fertility Society (SEF)/Association for the Study of Reproductive Biology (ASEBIR) screening recommendations? Summary answer The SARS-CoV-2 positivity rate in the centers following the SEF/ASEBIR screening recommendations was 0.316% after the first survey and 0.364% after t...
Cheong, Y Robertson, I Boivin, J
Published in
Human Reproduction (Oxford, England)
Study question Is the emotional experience of patients during IVF different since the start of the global Covid-19 pandemic? Summary answer Tracking data since re-opening demonstrated patients lower positive challenge emotions but no significant change in harm, threat, or stress. What is known already Covid-19 caused widespread shutdown of fertilit...
