Li, Manci Schifanella, Luca Larsen, Peter A.
Published in
Human Genomics
SARS-CoV-2 has spread rapidly across the world and is negatively impacting the global human population. COVID-19 patients display a wide variety of symptoms and clinical outcomes, including those attributed to genetic ancestry. Alu retrotransposons have played an important role in human evolution, and their variants influence host response to viral...
Laponogov, Ivan Gonzalez, Guadalupe Shepherd, Madelen Qureshi, Ahad Veselkov, Dennis Charkoftaki, Georgia Vasiliou, Vasilis Youssef, Jozef Mirnezami, Reza Bronstein, Michael
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Published in
Human Genomics
In this paper, we introduce a network machine learning method to identify potential bioactive anti-COVID-19 molecules in foods based on their capacity to target the SARS-CoV-2-host gene-gene (protein-protein) interactome. Our analyses were performed using a supercomputing DreamLab App platform, harnessing the idle computational power of thousands o...
Novelli, Giuseppe Biancolella, Michela Mehrian-Shai, Ruty Erickson, Caroline Godri Pollitt, Krystal J. Vasiliou, Vasilis Watt, Jessica Reichardt, Juergen K. V.
Published in
Human Genomics
The COVID-19 pandemic is sweeping the world and will feature prominently in all our lives for months and most likely for years to come. We review here the current state 6 months into the declared pandemic. Specifically, we examine the role of the pathogen, the host and the environment along with the possible role of diabetes. We also firmly believe...
Mehrian-Shai, Ruty
Published in
Human Genomics
It is crucial to use the wealth of information emerging from the ongoing SARS-CoV-2 pandemic and confront COVID-19 with a rational approach. There are proactive steps to prevent and fight COVID-19. Management of the disease should be according to clinical features and laboratory test markers and personalized therapeutic targets.
Zhang, Linlin Gao, Jinshuang Liu, Hailiang Tian, Yuan Zhang, Xiaoli Lei, Wei Li, Ying Guo, Yaqing Yu, Haiyang Yuan, Erfeng
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Published in
Human Genomics
BackgroundEpilepsy is a group of neurological disorders characterized by recurrent epileptic seizures. Epilepsy is affected by many factors, approximately 20–30% of cases are caused by acquired conditions, but in the remaining cases, genetic factors play an important role. Early establishment of a specific diagnosis is important to treat and manage...
Gao, Yingnan Du, Liping Li, Fuzhen Ding, Jiadong Li, Geng Cao, Qingfeng Li, Na Su, Guannan Kijlstra, Aize Yang, Peizeng
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Published in
Human Genomics
BackgroundSeveral studies have stated that TNF-α participates in the pathogenesis of scleritis, but also in several systemic autoimmune diseases and vasculitis, of which some are associated with scleritis. Earlier GWAS and SNP studies have confirmed that multiple SNPs of TNF related genes are associated with many immune-mediated disorders. The purp...
Ying, Yuyi Lu, Lu Banerjee, Santasree Xu, Lizhen Zhao, Qiang Wu, Hao Li, Ruiqi Xu, Xiao Yu, Hua Neculai, Dante
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Published in
Human Genomics
BackgroundGermline variants of ten keratin genes (K1, K2, K5, K6A, K6B, K9, K10, K14, K16, and K17) have been reported for causing different types of genodermatoses with an autosomal dominant mode of inheritance. Among all the variants of these ten keratin genes, most of them are missense variants. Unlike pathogenic and likely pathogenic variants, ...
Khodabandehloo, Fatemeh Taleahmad, Sara Aflatoonian, Reza Rajaei, Farzad Zandieh, Zahra Nassiri-Asl, Marjan Eslaminejad, Mohamadreza Baghaban
Published in
Human Genomics
BackgroundAdult bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stem cells that can differentiate into three lineages. They are suitable sources for cell-based therapy and regenerative medicine applications. This study aims to evaluate the hub genes and key pathways of differentially expressed genes (DEGs) related to osteogenes...
Mersha, Tesfaye B. Beck, Andrew F.
Published in
Human Genomics
An amendment to this paper has been published and can be accessed via the original article.
Krupenko, Natalia I. Sharma, Jaspreet Pediaditakis, Peter Helke, Kristi L. Hall, Madeline S. Du, Xiuxia Sumner, Susan Krupenko, Sergey A.
Published in
Human Genomics
BackgroundMitochondrial folate enzyme ALDH1L2 (aldehyde dehydrogenase 1 family member L2) converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 simultaneously producing NADPH. We have recently reported that the lack of the enzyme due to compound heterozygous mutations was associated with neuro-ichthyotic syndrome in a male patient. Here, w...