Heil, Peter Friedrich, Björn
Published in
Hearing research
Sensitivity to changes in the stimulus level at one or at both ears and to changes in the interaural level difference (ILD) between the two ears has been studied widely. Several different definitions of threshold and, for one of them, two different ways of averaging single-listener thresholds have been used (i.e., arithmetically and geometrically),...
Penn, Courtney Mayilsamy, Karthick Zhu, Xiao Xia Bauer, Mark A Mohapatra, Shyam S Frisina, Robert D Mohapatra, Subhra
Published in
Hearing research
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. Mounting evidence suggests that even mild TBI injuries, which comprise >75% of all TBIs, can cause chronic post-concussive neurological symptoms, especially when experienced repetitively (rTBI). The most common post-concussive symptoms include auditory dysfunction in t...
Lindboom, Elsa Nidiffer, Aaron Carney, Laurel H Lalor, Edmund C
Published in
Hearing research
The goal of describing how the human brain responds to complex acoustic stimuli has driven auditory neuroscience research for decades. Often, a systems-based approach has been taken, in which neurophysiological responses are modeled based on features of the presented stimulus. This includes a wealth of work modeling electroencephalogram (EEG) respo...
Sangaletti, Rachele Tamames, Ilmar Yahn, Stephanie Lynn Choi, James Seungyeon Lee, Jae K King, Curtis Rajguru, Suhrud M
Published in
Hearing research
Mild therapeutic hypothermia (MTH) has been demonstrated to prevent residual hearing loss from surgical trauma associated with cochlear implant (CI) insertion. Here, we aimed to characterize the mechanisms of MTH-induced hearing preservation in CI in a well-established preclinical rodent model. Rats were divided into four experimental conditions: M...
Ritter, K Elaine Lynch, Sloane M Gorris, Ashley M Beyer, Lisa A Kabara, Lisa Dolan, David F Raphael, Yehoash Martin, Donna M
Published in
Hearing research
CHARGE syndrome is a multiple anomaly developmental disorder characterized by a variety of sensory deficits, including sensorineural hearing loss of unknown etiology. Most cases of CHARGE are caused by heterozygous pathogenic variants in CHD7, the gene encoding Chromodomain DNA-binding Protein 7 (CHD7), a chromatin remodeler important for the devel...
Balendran, Vinodh Ritter, K Elaine Martin, Donna M
Published in
Hearing research
Epigenetic factors are critically important for embryonic and postnatal development. Over the past decade, substantial technological advancements have occurred that now permit the study of epigenetic mechanisms that govern all aspects of inner ear development, from otocyst patterning to maturation and maintenance of hair cell stereocilia. In this r...
Pouyo, Ronald Chung, Keshi Delacroix, Laurence Malgrange, Brigitte
Published in
Hearing research
Post-translational modifications of proteins are essential for the proper development and function of many tissues and organs, including the inner ear. Ubiquitination is a highly selective post-translational modification that involves the covalent conjugation of ubiquitin to a substrate protein. The most common outcome of protein ubiquitination is ...
Claussen, Alexander D Quevedo, René Vielman Kirk, Jonathon R Higgins, Timon Mostaert, Brian Rahman, Muhammad Taifur Oleson, Jacob Hernandez, Reyna Hirose, Keiko Hansen, Marlan R
...
Published in
Hearing research
Cochlear implantation is an effective auditory rehabilitation strategy for those with profound hearing loss, including those with residual low frequency hearing through use of hybrid cochlear implantation techniques. Post-mortem studies demonstrate the nearly ubiquitous presence of intracochlear fibrosis and neo-ossification following cochlear impl...
Relaño-Iborra, Helia Dau, Torsten
Published in
Hearing research
Speech intelligibility models can provide insights regarding the auditory processes involved in human speech perception and communication. One successful approach to modelling speech intelligibility has been based on the analysis of the amplitude modulations present in speech as well as competing interferers. This review covers speech intelligibili...
Prud'homme, Luna Lavandier, Mathieu Best, Virginia
Published in
Hearing research
This study investigated the role of harmonic cancellation in the intelligibility of speech in "cocktail party" situations. While there is evidence that harmonic cancellation plays a role in the segregation of simple harmonic sounds based on fundamental frequency (F0), its utility for mixtures of speech containing non-stationary F0s and unvoiced seg...
