Categorisation of natural sounds at different stages of auditory recovery in cochlear implant adult deaf patients
Published in Hearing Research
Novel myosin mutations for hereditary hearing loss revealed by targeted genomic capture and massively parallel sequencin...
...Published in European journal of human genetics : EJHG
Hereditary hearing loss is genetically heterogeneous, with a large number of genes and mutations contributing to this sensory, often monogenic, disease. This number, as well as large size, precludes comprehensive genetic diagnosis of all known deafness genes. A combination of targeted genomic capture and massively parallel sequencing (MPS), also re...
Cochlear implantation in the mouse via the round window: effects of array insertion.
Published in Hearing research
Animal models are the only means of assessing the effects of cochlear implantation (CI) at a cellular and molecular level. The range of naturally occurring and genetically-modified mouse strains which mimic human deafness provide excellent opportunities for auditory research. To date, there are very few studies of CI in mice. The main aims of this ...
Viscoelastic properties of the human tympanic membrane studied with stroboscopic holography and finite element modeling....
Published in Hearing research
A new anatomically-accurate Finite Element (FE) model of the tympanic membrane (TM) and malleus was combined with measurements of the sound-induced motion of the TM surface and the bony manubrium, in an isolated TM-malleus preparation. Using the results, we were able to address two issues related to how sound is coupled to the ossicular chain: (i) ...
Evaluation of the sparse coding shrinkage noise reduction algorithm in normal hearing and hearing impaired listeners.
Published in Hearing research
Although there are numerous single-channel noise reduction strategies to improve speech perception in noise, most of them improve speech quality but do not improve speech intelligibility, in circumstances where the noise and speech have similar frequency spectra. Current exceptions that may improve speech intelligibility are those that require a pr...
Sensory substitution information informs locomotor adjustments when walking through apertures.
Published in Experimental brain research
The study assessed the ability of the central nervous system (CNS) to use echoic information from sensory substitution devices (SSDs) to rotate the shoulders and safely pass through apertures of different width. Ten visually normal participants performed this task with full vision, or blindfolded using an SSD to obtain information regarding the wid...
Top-down restoration of speech in cochlear-implant users.
Published in Hearing research
In noisy listening conditions, intelligibility of degraded speech can be enhanced by top-down restoration. Cochlear implant (CI) users have difficulty understanding speech in noisy environments. This could partially be due to reduced top-down restoration of speech, which may be related to the changes that the electrical stimulation imposes on the b...
Left hemisphere fractional anisotropy increase in noise-induced tinnitus: a diffusion tensor imaging (DTI) study of whit...
Published in Hearing research
Diffusion tensor imaging (DTI) is a contemporary neuroimaging modality used to study connectivity patterns and microstructure of white matter tracts in the brain. The use of DTI in the study of tinnitus is a relatively unexplored methodology with no studies focusing specifically on tinnitus induced by noise exposure. In this investigation, particip...
Effects of cochlear ablation on amino acid levels in the rat cochlear nucleus and superior olive.
Published in Hearing research
Amino acids have important roles in the chemistry of the auditory system, including communication among neurons. There is much evidence for glutamate as a neurotransmitter from auditory nerve fibers to cochlear nucleus neurons. Previous studies in rodents have examined effects of removal of auditory nerve input by cochlear ablation on levels, uptak...
Effects of lexical tone contour on Mandarin sentence intelligibility.
Published in Journal of speech, language, and hearing research : JSLHR
Consistent with previous findings to some extent, the present findings suggest that lexical tones are relatively redundant cues for Mandarin sentence intelligibility in quiet and that other cues could compensate for the distorted lexical tone contour. However, in noise, the results provide direct evidence that lexical tone contour is important for ...
