Published in Hearing Research
• Dclk1 may play a role in progressive age-related hearing loss. • A430005L14Rik may play a role in the susceptibility of the auditory system to noise-damage. • Fifteen other candidate genes (from GWAS) knocked out or knocked down in mutant mice do not lead to changes in ABRs.
Published in Hearing research
The relative importance of neural temporal and place coding in auditory perception is still a matter of much debate. The current article is a compilation of viewpoints from leading auditory psychophysicists and physiologists regarding the upper frequency limit for the use of neural phase locking to code temporal fine structure in humans. While phas...
Published in Hearing Research
• Given careful measurement techniques, ABR and EFR amplitudes can be highly reliable. • The same is true of MEMR thresholds and MEMR across-frequency threshold difference. • Differential ABR and EFR measures exhibit only poor-to-moderate reliability. • Correlations between measures are not evident in young people with normal audiograms. • Proxy me...
Published in Hearing research
A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. However, the link to tinnitus has not been properly established because GPIAS has not yet been used to obj...
Published in Hearing research
The capacity of the auditory system to extract spatial information relies principally on the detection and interpretation of binaural cues, i.e., differences in the time of arrival or level of the sound between the two ears. In this review, we consider the effects of unilateral or asymmetric hearing loss on spatial hearing, with a focus on the adap...
Published in Hearing research
Previous studies have demonstrated that cochlear implant (CI) patients are more efficient at performing sound categorisation than sound identification. However, it remains unclear how this categorisation capacity develops with time during the rehabilitation period after implantation. To investigate the role of the post-implantation auditory experie...
Published in Hearing Research
•Cochlear implantation via the round window was performed in C57Bl/6 mice.•Cone beam CT and microscopy confirmed implant placement within the scala tympani.•ABR testing revealed a small elevation in thresholds in implanted ears vs. controls.•Encapsulation of the implant in fibrotic-type tissue was observed.
Published in Hearing Research
•Analyses of transgenic mice show substantial central auditory function of deafness genes.•Deafness genes are enriched in the transcriptome of the auditory brainstem.•Shared genetic program during development of peripheral and central auditory system.•Novel sequencing techniques will allow affordable genetic diagnosis.•Knowledge of central auditory...
Published in Hearing Research
•Electric and infrared neural stimulation (INS) was applied to the cochlear nucleus.•Electric stimulation elicited collicular and auditory brainstem responses (ABRs).•INS also elicited colliculular responses & ABRs similar to acoustically-evoked ABRs.•Deafening decreased INS responses, suggesting their generation by a laser artifact.
Published in Hearing Research
•The ratio of the oVEMP amplitude to 500 and 1000 Hz may be diagnostically valuable in Menière's disease.•For Menière's ears, this ratio is significantly smaller compared to contralateral Menière's ears and healthy controls.•There is an association of an older age and a diminished amplitude ratio in healthy controls but not in Menière's ears.
