Carcagno, Samuele Plack, Christopher J.
Published in
Hearing Research
Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. It is not known to what extent age-related CS occurs in humans, and how it affects the coding of supra-threshold sounds and speech in noise. Because in rod...
Aman, Lucie Picken, Samantha Andreou, Lefkothea-Vasiliki Chait, Maria
Published in
Hearing Research
The notion that sensitivity to the statistical structure of the environment is pivotal to perception has recently garnered considerable attention. Here we investigated this issue in the context of hearing. Building on previous work ( Sohoglu and Chait, 2016a ; elife), stimuli were artificial ‘soundscapes’ populated by multiple (up to 14) simultaneo...
Friston, Karl J. Sajid, Noor Quiroga-Martinez, David Ricardo Parr, Thomas Price, Cathy J. Holmes, Emma
Published in
Hearing Research
• Describes a generative model for synthesising and recognising speech. • Considers speech segmentation (placing word boundaries) as an active process. • Treats speech segmentation and lexical inferences as complementary. • Associates neural mismatch responses (e.g., MMN) with belief updating.
Carcagno, Samuele Plack, Christopher J.
Published in
Hearing Research
Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the ratio of the amplitude of wave...
Davis, Samantha N Wu, Patricia Camci, Esra D Simon, Julian A Rubel, Edwin W Raible, David W
Published in
Hearing research
Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimen...
Ingham, Neil J Rook, Victoria Di Domenico, Francesca James, Elysia Lewis, Morag A Girotto, Giorgia Buniello, Annalisa Steel, Karen P
Published in
Hearing research
The underlying causes of age-related hearing loss (ARHL) are not well understood, but it is clear from heritability estimates that genetics plays a role in addition to environmental factors. Genome-wide association studies (GWAS) in human populations can point to candidate genes that may be involved in ARHL, but follow-up analysis is needed to asse...
Verschooten, Eric Shamma, Shihab Oxenham, Andrew J Moore, Brian C J Joris, Philip X Heinz, Michael G Plack, Christopher J
Published in
Hearing research
The relative importance of neural temporal and place coding in auditory perception is still a matter of much debate. The current article is a compilation of viewpoints from leading auditory psychophysicists and physiologists regarding the upper frequency limit for the use of neural phase locking to code temporal fine structure in humans. While phas...
Guest, Hannah Munro, Kevin J. Prendergast, Garreth Plack, Christopher J.
Published in
Hearing Research
• Given careful measurement techniques, ABR and EFR amplitudes can be highly reliable. • The same is true of MEMR thresholds and MEMR across-frequency threshold difference. • Differential ABR and EFR measures exhibit only poor-to-moderate reliability. • Correlations between measures are not evident in young people with normal audiograms. • Proxy me...
Wilson, Caroline A Berger, Joel I de Boer, Jessica Sereda, Magdalena Palmer, Alan R Hall, Deborah A Wallace, Mark N
Published in
Hearing research
A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. However, the link to tinnitus has not been properly established because GPIAS has not yet been used to obj...
Kumpik, Daniel P King, Andrew J
Published in
Hearing research
The capacity of the auditory system to extract spatial information relies principally on the detection and interpretation of binaural cues, i.e., differences in the time of arrival or level of the sound between the two ears. In this review, we consider the effects of unilateral or asymmetric hearing loss on spatial hearing, with a focus on the adap...
