Drayson, Mark T Bowcock, Stella Planche, Tim Iqbal, Gulnaz Pratt, Guy Yong, Kwee Wood, Jill Raynes, Kerry Higgins, Helen Dawkins, Bryony
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Published in
Health technology assessment (Winchester, England)
During the 12 weeks from new diagnosis of myeloma, the addition of prophylactic levofloxacin to active myeloma treatment significantly reduced the number of febrile episodes and deaths [134 (febrile episodes alone, n = 112; febrile episodes plus death, n = 7; deaths alone, n = 15) out of 488 (27%) placebo patients vs. 95 (febrile episodes alone, n ...
Cook, Jonathan A Julious, Steven A Sones, William Hampson, Lisa V Hewitt, Catherine Berlin, Jesse A Ashby, Deborah Emsley, Richard Fergusson, Dean A Walters, Stephen J
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Published in
Health technology assessment (Winchester, England)
This Difference ELicitation in TriAls2 (DELTA2) advice and recommendations document aims to help researchers choose the ‘target difference’ in a type of research study called a randomised controlled trial. The number of people needed to be involved in a study – the sample size – is usually based on a calculation aimed to ensure that the difference ...
St James-Roberts, Ian Garratt, Rosemary Powell, Charlotte Bamber, Deborah Long, Jaqui Brown, Jayne Morris, Stephen Dyson, Sue Morris, Tom Bhupendra Jaicim, Nishal
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Published in
Health technology assessment (Winchester, England)
In stage 1 of the study (development of an intervention package), the research evidence was reviewed and parents whose babies previously cried excessively and NHS health visitors (HVs) and specialist community public health nurses (SCPHNs) were involved to develop evidence-based support materials. These included a website, a printed booklet and sup...
Allan, Louise M Wheatley, Alison Smith, Amy Flynn, Elizabeth Homer, Tara Robalino, Shannon Beyer, Fiona R Fox, Christopher Howel, Denise Barber, Robert
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Published in
Health technology assessment (Winchester, England)
People with dementia fall over more often than people who do not have dementia. When they fall over, they are more likely to hurt themselves. They do not get better as easily as people without dementia. After hurting themselves, people with dementia may need a lot more help in looking after themselves. They, and their carer, may not have such a goo...
Madan, Ira Parsons, Vaughan Ntani, Georgia Wright, Alison English, John Coggon, David McCrone, Paul Smedley, Julia Rushton, Lesley Murphy, Caroline
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Published in
Health technology assessment (Winchester, England)
This study was designed to prevent nurses from developing hand dermatitis (eczema). The study recruited student and intensive care unit nurses who were at high risk of hand dermatitis. Overall, 35 study sites took part. Each site was randomised to be in either the ‘intervention plus’ or the ‘intervention light’ group. Participants in the interventi...
Cooper, Kevin Breeman, Suzanne Scott, Neil W Scotland, Graham Hernández, Rodolfo Clark, T Justin Hawe, Jed Hawthorn, Robert Phillips, Kevin Wileman, Samantha
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Published in
Health technology assessment (Winchester, England)
Almost 1.5 million women in England and Wales suffer from heavy periods. Initial treatment involves tablets or a medicated coil inserted within the womb. Sometimes these treatments do not work and many women need an operation, either endometrial ablation (EA) (removing the lining of the womb) or a full hysterectomy (complete removal of the womb). P...
Griffiths, Paul D Bradburn, Michael Campbell, Michael J Cooper, Cindy L Embleton, Nicholas Graham, Ruth Hart, Anthony R Jarvis, Deborah Kilby, Mark D Lie, Mabel
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Published in
Health technology assessment (Winchester, England)
Ultrasonography is routine in pregnancy to check that the baby’s brain is developing as expected. However, no medical test is perfect and ultrasonography may miss some brain abnormalities, may get some brain abnormalities wrong or may diagnose an abnormality that is not really present. Magnetic resonance imaging (MRI) may help clarify difficult cas...
Perkins, Gavin D Mistry, Dipesh Lall, Ranjit Gao-Smith, Fang Snelson, Catherine Hart, Nicholas Camporota, Luigi Varley, James Carle, Coralie Paramasivam, Elankumaran
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Published in
Health technology assessment (Winchester, England)
Patients who become very unwell may require help from a breathing machine. This requires the patient to be given drugs to put them to sleep (sedation) and have a tube placed through their mouth directly into the windpipe (tube ventilation). This can be life-saving, but may cause harm if used for long periods of time. Non-invasive ventilation (mask ...
Peckham, Emily Arundel, Catherine Bailey, Della Crosland, Suzanne Fairhurst, Caroline Heron, Paul Hewitt, Catherine Li, Jinshuo Parrott, Steve Bradshaw, Tim
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Published in
Health technology assessment (Winchester, England)
Smoking is an important health issue, especially among people who have experienced mental ill health such as schizophrenia or bipolar disorder. This is because people with severe mental ill health (SMI) are more likely to smoke than the general population. Despite this, they are less likely to get help to stop smoking, and it may be that people wit...
Griffin, Xavier L Costa, Matthew L Phelps, Emma Parsons, Nicholas Dritsaki, Melina Png, May Ee Achten, Juul Tutton, Elizabeth Lerner, Robin McGibbon, Alwin
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Published in
Health technology assessment (Winchester, England)
Breaks of the lower end of the thigh bone are increasingly common injuries. Two operations are used to treat these injuries: a rod placed along the centre of the bone or a plate attached to the edge of the bone. It is not clear which is better. We report the results from a study that will help develop the design of a definitive study to test which ...
