Mouncey, Paul R Richards-Belle, Alvin Thomas, Karen Harrison, David A Sadique, M Zia Grieve, Richard D Camsooksai, Julie Darnell, Robert Gordon, Anthony C Henry, Doreen
...
Published in
Health technology assessment (Winchester, England)
Low blood pressure is common in patients in intensive care. It is associated with a high risk of death. It can be treated with drugs called vasopressors. These drugs raise blood pressure, but also come with risks and side effects. Usually, a blood pressure target is used to guide how much of the drugs to give to patients. Two previous clinical tria...
Primrose, John N Pugh, Siân A Thomas, Gareth Ellis, Matthew Moutasim, Karwan Mant, David
Published in
Health technology assessment (Winchester, England)
Bowel cancer (also known as colorectal cancer) is the fourth commonest cancer in the UK. When the cancer is confined to the bowel and/or the surrounding lymph nodes (early bowel cancer), it is typically treated with an operation to remove the cancer with or without the addition of chemotherapy. Following this treatment, many patients will be cured,...
Richardson, Kathryn Savva, George M Boyd, Penelope J Aldus, Clare Maidment, Ian Pakpahan, Eduwin Loke, Yoon K Arthur, Antony Steel, Nicholas Ballard, Clive
...
Published in
Health technology assessment (Winchester, England)
We found that people living with dementia who take Z-drugs are more likely to break a bone or to die sooner than similar people with dementia who are not taking Z-drugs. However, we cannot be certain that these problems are caused by Z-drugs, as many other factors can also lead to broken bones and death. Further work is needed to clarify the risk o...
Allotey, John Snell, Kym Ie Smuk, Melanie Hooper, Richard Chan, Claire L Ahmed, Asif Chappell, Lucy C von Dadelszen, Peter Dodds, Julie Green, Marcus
...
Published in
Health technology assessment (Winchester, England)
Before using the International Prediction of Pregnancy Complications models in various populations, they need to be adjusted for characteristics of the particular population and the setting of application.
Hagen, Suzanne Bugge, Carol Dean, Sarah G Elders, Andrew Hay-Smith, Jean Kilonzo, Mary McClurg, Doreen Abdel-Fattah, Mohamed Agur, Wael Andreis, Federico
...
Published in
Health technology assessment (Winchester, England)
Urinary incontinence (accidental leakage of urine) is a common and embarrassing problem for women. Pregnancy and childbirth may contribute by leading to less muscle support and bladder control. Pelvic floor exercises and ‘biofeedback’ equipment (a device that lets women see the muscles working as they exercise) are often used in treatment. There is...
Pickard, Robert Goulao, Beatriz Carnell, Sonya Shen, Jing MacLennan, Graeme Norrie, John Breckons, Matt Vale, Luke Whybrow, Paul Rapley, Tim
...
Published in
Health technology assessment (Winchester, England)
The urethra carries urine from the bladder to the tip of the penis. Men can develop a condition called urethral stricture when part of the urethra narrows due to scarring. This can lead to difficulties in passing urine and can recur. There are two operations for urethral stricture. The standard approach is endoscopic urethrotomy. The alternative is...
Armstrong, Nigel Büyükkaramikli, Nasuh Penton, Hannah Riemsma, Rob Wetzelaer, Pim Huertas Carrera, Vanesa Swift, Stephanie Drachen, Thea Raatz, Heike Ryder, Steve
...
Published in
Health technology assessment (Winchester, England)
Thrombocytopenia, which is a reduction in platelet numbers in the blood, is a common complication of chronic liver disease. It increases the risk of bleeding during procedures including liver biopsy and transplantation. It can delay or prevent procedures, leading to illness and death. Established treatment largely involves platelet transfusion befo...
Bray, Nathan Kolehmainen, Niina McAnuff, Jennifer Tanner, Louise Tuersley, Lorna Beyer, Fiona Grayston, Aimee Wilson, Dor Edwards, Rhiannon Tudor Noyes, Jane
...
Published in
Health technology assessment (Winchester, England)
The aim of this study was to find out the benefits and costs of providing very young children, aged
Dias, Joseph Brealey, Stephen Cook, Liz Fairhurst, Caroline Hinde, Sebastian Leighton, Paul Choudhary, Surabhi Costa, Matthew Hewitt, Catherine Hodgson, Stephen
...
Published in
Health technology assessment (Winchester, England)
Fracture of the scaphoid bone (one of eight small bones in the wrist) is common in young active people. It is caused by a fall on the hand or the hand being suddenly forced backwards. The usual treatment is to rest the wrist in a plaster cast for 6–10 weeks and allow the broken bone to heal. In 1 in 10 cases in which the fracture is treated in a pl...
Rodgers, Helen Bosomworth, Helen Krebs, Hermano I van Wijck, Frederike Howel, Denise Wilson, Nina Finch, Tracy Alvarado, Natasha Ternent, Laura Fernandez-Garcia, Cristina
...
Published in
Health technology assessment (Winchester, England)
Many people who have arm weakness following a stroke feel that insufficient attention is paid by rehabilitation services to recovery of their arm. Unfortunately, it is currently unclear how best to provide rehabilitation to optimise recovery, but robot-assisted training and therapy programmes that focus on practising functional tasks are promising ...
