CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness gene...
Published in Haematologica
A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leuk...
...Published in Haematologica
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34+ CD38low chronic phase CML cells. Out of the 313 uni...
Comparing the two leading erythroid lines BEL-A and HUDEP-2.
...Published in Haematologica
Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.
Published in Haematologica
Lysine specific demethylase-1 (LSD1) has been shown to be critical in acute myeloid leukemia (AML) pathogenesis and this has led to the development of LSD1 inhibitors (LSD1i) which are currently tested in clinical trials. Nonetheless, preclinical studies reported that AML cells frequently exhibit intrinsic resistance to LSD1 inhibition, and the mol...
Selinexor combined with cladribine, cytarabine, and filgrastim in relapsed or refractory acute myeloid leukemia.
...Published in Haematologica
Cryptic insertions of the immunoglobulin light chain enhancer region near CCND1 in t(11;14)-negative mantle cell lymphom...
...Published in Haematologica
Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study.
Published in Haematologica
Vitamin K-dependent carboxylation is a post-translational modification essential for the biological function of coagulation factors. Defects in carboxylation are mainly associated with bleeding disorders. With the discovery of new vitamin K-dependent proteins, the importance of carboxylation now encompasses vascular calcification, bone metabolism, ...
Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage.
...Published in Haematologica
Macaques are emerging as a critical animal model in transfusion medicine, because of their evolutionary similarity to humans and perceived utility in discovery and translational science. However, little is known about the metabolism of Rhesus macaque red blood cells (RBC) and how this compares to human RBC metabolism under standard blood banking co...
EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase.
...Published in Haematologica
Metabolic reprogramming of leukemia cells is important for survival, proliferation, and drug resistance under conditions of metabolic stress in the bone marrow. Deregulation of cellular metabolism, leading to development of leukemia, occurs through abnormally high expression of transcription factors such as MYC and Ecotropic Virus Integration site ...
Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin.
Published in Haematologica
