Zalmaï, Loria Viailly, Pierre-Julien Biichle, Sabeha Cheok, Meyling Soret, Lou Angelot-Delettre, Fanny Petrella, Tony Collonge-Rame, Marie-Agnès Seilles, Estelle Geffroy, Sandrine
...
Published in
Haematologica
Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origi...
Zeissig, Mara N Hewett, Duncan R Panagopoulos, Vasilios Mrozik, Krzysztof M To, L Bik Croucher, Peter I Zannettino, Andrew C W Vandyke, Kate
Published in
Haematologica
Multiple myeloma (MM) disease progression is dependent on the ability of MM plasma cells (PCs) to egress from the bone marrow (BM), enter the circulation and disseminate to distal BM sites. Expression of the chemokine CXCL12 by BM stromal cells is crucial for MM PC retention within the BM. However, the mechanisms which overcome CXCL12-mediated rete...
Sargas, Claudia Ayala, Rosa Chillón, María Carmen Larráyoz, María J Carrillo-Cruz, Estrella Bilbao, Cristina Yébenes-Ramírez, Manuel Llop, Marta Rapado, Inmaculada García-Sanz, Ramón
...
Published in
Haematologica
Next-Generation Sequencing has recently been introduced to efficiently and simultaneously detect genetic variations in acute myeloid leukemia. However, its implementation in the clinical routine raises new challenges focused on the diversity of assays and variant reporting criteria. To overcome this challenge, the PETHEMA group established a nation...
Antić, Željko Yu, Jiangyan Van Reijmersdal, Simon V Van Dijk, Anke Dekker, Linde Segerink, Wouter H Sonneveld, Edwin Fiocco, Marta Pieters, Rob Hoogerbrugge, Peter M
...
Published in
Haematologica
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes. However, the clinical relevance of these subclonal alterations remains unclear. We assessed the clinical relevance and prognostic value of subclonal altera...
Tang, Tiffany Martin, Peter Somasundaram, Nagavalli Lim, Cindy Tao, Miriam Poon, Eileen Yunon, Maica Jd Toh, Shu Q Yan, Sean X Farid, Mohamad
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Published in
Haematologica
Selinexor is a selective inhibitor of nuclear export with anti-cancer properties. We performed a phase I study to determine the safety and maximum tolerated dose (MTD) of selinexor when combined with high-dose dexamethasone, ifosfamide, carboplatin and etoposide (DICE) in relapsed/refractory (R/R) T-cell lymphoma (TCL) and natural-killer/T-cell lym...
Bohler, Sheila Afreen, Sehar Fernandez-Orth, Juncal Demmerath, Eva-Maria Molnar, Christian Wu, Ying Weiss, Julia Miriam Mittapalli, Venugopal Rao Konstantinidis, Lukas Schmal, Hagen
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Published in
Haematologica
BH3-mimetics inhibiting anti-apoptotic BCL-2 proteins represent a novel and promising class of antitumor drugs. While the BCL-2 inhibitor venetoclax is already FDA-approved, BCL-XL and MCL-1 inhibitors are currently in early clinical trials. To predict side effects of therapeutic MCL-1 inhibition on the human hematopoietic system, we used RNAi and ...
Schino, Mattia Fiorentino, Vincenzo Rossi, Elena Betti, Silvia Di Cecca, Monica Ranucci, Valentina Chiusolo, Patrizia Martini, Maurizio De Stefano, Valerio Larocca, Luigi Maria
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Published in
Haematologica
Philadelphia-negative chronic myeloproliferative neoplasms (MPN) have been traditionally considered as indistinctly slowly progressing conditions; recent evidence proves that a subset of cases have a rapid evolution, so that MPN prognosis needs to be personalized. We identified a new morphological parameter, defined as megakaryocytic activation (M-...
Nairz, Manfred Metzendorf, Christoph Vujic-Spasic, Maja Mitterstiller, Anna-Maria Schroll, Andrea Haschka, David Hoffmann, Alexander Von Raffay, Laura Sparla, Richard Huck, Christian W
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Published in
Haematologica
Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells. HFE encodes an MHC-I like molecule, but its function in immune responses to infection remains incompletely understood. Here, we investigated putative roles of Hfe in myeloid cells a...
Petersdorf, Effie W Gooley, Ted Volt, Fernanda Kenzey, Chantal Madrigal, Alejandro McKallor, Caroline Querol, Sergio Rafii, Hanadi Rocha, Vanderson Tamouza, Ryad
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Published in
Haematologica
Cord-blood transplantation (CBT) can cure life-threatening blood disorders. The HLA-B leader affects the success of unrelated donor transplantation but its role in CBT is unknown. We tested the hypothesis that the HLA-B leader influences CBT outcomes in unrelated single-unit cord-blood transplants performed by Eurocord/European Blood and Marrow Tra...
Pozzo, Federico Bittolo, Tamara Tissino, Erika Vit, Filippo Vendramini, Elena Laurenti, Luca D'Arena, Giovanni Olivieri, Jacopo Pozzato, Gabriele Zaja, Francesco
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Published in
Haematologica
Chronic lymphocytic leukemia (CLL) is characterized by a low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations of the NOTCH1 gene. In the present study, by taking advantage of a wide and well-characterized CLL cohort (n=537), we demonstrate that CD20 expression is downregulated in SF3B1-mutated CLL in ...
