Straubhar, Alli M Chi, Andrew J Zhou, Qin C Iasonos, Alexia Filippova, Olga T Leitao, Mario M Jr Awowole, Ibraheem O Abu-Rustum, Nadeem R Broach, Vance A Jewell, Elizabeth L
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Published in
Gynecologic oncology
To explore pre-operative factors and their impact on overall survival (OS) in a modern cohort of patients who underwent pelvic exenteration (PE) for gynecologic malignancies. A retrospective review was performed for all patients who underwent a PE from 1/1/2010 through 12/31/2018 at our institution. Inclusion criteria were exenteration due to recur...
Gupta, Vijayalaxmi G Hirst, Jeff Petersen, Shariska Roby, Katherine F Kusch, Meghan Zhou, Helen Clive, Makena L Jewell, Andrea Pathak, Harsh B Godwin, Andrew K
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Published in
Gynecologic oncology
Poly ADP ribose polymerase inhibitors (PARPi) are most effective in BRCA1/2 mutated ovarian tumors. Better treatments are needed for homologous recombination HR-proficient cancer, including CCNE1 amplified subtypes. We have shown that histone deacetylase inhibitors (HDACi) sensitize HR-proficient ovarian cancer to PARPi. In this study, we provide c...
Gonzalez-Bosquet, Jesus Bakkum-Gamez, Jamie N Weaver, Amy L McGree, Michaela E Dowdy, Sean C Famuyide, Abimbola O Kipp, Benjamin R Halling, Kevin C Couch, Fergus J Podratz, Karl C
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Published in
Gynecologic oncology
PI3K-AKT pathway mutations initiate a kinase cascade that characterizes endometrial cancer (EC). As kinases seldom cause oncogenic transformation without dysregulation of antagonistic phosphatases, pivotal interactions governing this pathway were explored and correlated with clinical outcomes. After exclusion of patients with POLE mutations from Th...
Fleming, Nicole D Westin, Shannon N Rauh-Hain, J Alejandro Soliman, Pamela T Fellman, Bryan M Coleman, Robert L Meyer, Larissa A Shafer, Aaron Cobb, Lauren P Jazaeri, Amir
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Published in
Gynecologic oncology
To evaluate the factors associated with response to neoadjuvant chemotherapy (NACT) and the ability to undergo interval tumor reductive surgery (iTRS) in patients with advanced ovarian cancer. We performed a retrospective review from April 2013 to March 2019 of patients with advanced stage ovarian cancer triaged to NACT based on our standard triage...
Deng, Mengqi Wu, Di Zhang, Yanqin Jin, Zhaoyu Miao, Jinwei
Published in
Gynecologic oncology
B7-H3 is a member of the B7 family of immune checkpoint molecule. Although B7-H3 has been shown to regulate T cell-mediated peripheral immune response, whether it also correlated with NK cell exhaustion in ovarian cancer remains unclear. The purpose of this study was to explore the mechanism of B7-H3 regulating NK-cell proliferation and function. T...
Fang, Chenyan Zhang, Ping Yu, Aijun Yang, Yue Zhang, Jiejie
Published in
Gynecologic oncology
Previous studies have evaluated the prognostic factors of patients with stage IIIB cervical cancer. However, there was only one study evaluating the relationship between LTI (lower third of vaginal invasion) and the prognosis of the patients with stage IIIB cervical cancer. Our research aimed to assess different therapeutic outcomes of the stage II...
Kasuga, Yoshifumi Ikenoue, Satoru Tanaka, Mamoru Ochiai, Daigo
Published in
Gynecologic oncology
Radical trachelectomy (RT) is a surgery for early-stage cervical cancer treatment that preserves the childbearing ability, and its use has become increasingly common worldwide. Thus, the rate of conception in women who have undergone RT is increasing. However, pregnancy after RT is associated with a higher risk of several obstetric complications su...
Maramai, M Achilarre, M T Aloisi, A Betella, I Bogliolo, S Garbi, A Maruccio, M Quatrale, C Aletti, G D Mariani, A
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Published in
Gynecologic oncology
To evaluate the role of cervical re-injection of indocyanine green (ICG) to increase the detection rate of sentinel lymph node (SLN) in patients with endometrial cancer (EC) who underwent robotic-assisted surgical staging. We retrospectively identified consecutive EC patients undergoing robotic-assisted staging with SLN biopsy at our Institution be...
Giannone, G Scotto, G Katsaros, D De Giorgi, U Farolfi, A Borella, F Cosma, S Ferrero, A Mangiacotti, S Villa, M
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Published in
Gynecologic oncology
Hypersensitivity reactions (HSRs) to platinum are an important issue in the treatment of patients (pts) with ovarian cancer (OC). Germline BRCA mutations have been proposed as a risk factor. We aimed at evaluating the incidence and severity of HSRs to platinum in OC pts. with known BRCA status. We retrospectively analyzed 432 pts. from 5 Italian Ce...
Tone, Alicia A McCuaig, Jeanna M Ricker, Nicole Boghosian, Talin Romagnuolo, Tina Stickle, Natalie Virtanen, Carl Zhang, Tong Kim, Raymond H Ferguson, Sarah E
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Published in
Gynecologic oncology
Up to 20% of high-grade serous ovarian carcinomas (HGSOC) are hereditary; however, historical uptake of genetic testing is low. We used a unique combination of approaches to identify women in Ontario, Canada, with a first-degree relative (FDR) who died from HGSOC without prior genetic testing, and offer them multi-gene panel testing. From May 2015-...
