Meynier, Maëva Baudu, Elodie Rolhion, Nathalie Defaye, Manon Straube, Marjolène Daugey, Valentine Modoux, Morgane Wawrzyniak, Ivan Delbac, Frédéric Villéger, Roamin
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Gut microbes
Alterations in brain/gut/microbiota axis are linked to Irritable Bowel Syndrome (IBS) physiopathology. Upon gastrointestinal infection, chronic abdominal pain and anxio-depressive comorbidities may persist despite pathogen clearance leading to Post-Infectious IBS (PI-IBS). This study assesses the influence of tryptophan metabolism, and particularly...
Nunez, Natalia Derré-Bobillot, Aurélie Trainel, Nicolas Lakisic, Goran Lecomte, Alexandre Mercier-Nomé, Françoise Cassard, Anne-Marie Bierne, Hélène Serror, Pascale Archambaud, Cristel
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Enterococcus faecalis is a bacterial species present at a subdominant level in the human gut microbiota. This commensal turns into an opportunistic pathogen under specific conditions involving dysbiosis and host immune deficiency. E. faecalis is one of the rare pathobionts identified to date as contributing to liver damage in alcoholic liver diseas...
Sencio, Valentin Machelart, Arnaud Robil, Cyril Benech, Nicolas Hoffmann, Eik Galbert, Chloé Deryuter, Lucie Heumel, Séverine Hantute-Ghesquier, Aline Flourens, Anne
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Gut Microbes
Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster mod...
Clancy, Robert M Marion, Miranda C Ainsworth, Hannah C Chang, Miao Howard, Timothy D Izmirly, Peter M Masson, Mala Buyon, Jill P Langefeld, Carl D
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Gut microbes
Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from completely asymptomatic to overt Systemic Lupus Erythematosus (SLE) or Sjögren's Syndrome (SS). This study was initiated to test the hypothesis that the microbiome, influenced in part by genet...
Čipčić Paljetak, Hana Barešić, Anja Panek, Marina Perić, Mihaela Matijašić, Mario Lojkić, Ivana Barišić, Ana Vranešić Bender, Darija Ljubas Kelečić, Dina Brinar, Marko
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Gut Microbes
The knowledge on how gut microbes contribute to the inflammatory bowel disease (IBD) at the onset of disease is still scarce. We compared gut microbiota in newly diagnosed, treatment-naïve adult IBD (Crohn’s disease (CD) and ulcerative colitis (UC)) to irritable bowel syndrome (IBS) patients and healthy group. Mucosal and fecal microbiota of 49 pat...
Vliex, Lars M. M. Le, Giang N. Fassarella, Marina Reijnders, Dorien Goossens, Gijs H. Zoetendal, Erwin G. Penders, John Blaak, Ellen E.
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Gut Microbes
Detrimental consequences of antibiotic treatment may include long-lasting disruption of the gut microbiota. Previous studies found no negative effects of antibiotics on metabolic health, although individualized responses were observed. Here, we aimed to investigate the subject-specific response to vancomycin use in tissue-specific insulin sensitivi...
Wei, Shaodong Bahl, Martin Iain Baunwall, Simon Mark Dahl Dahlerup, Jens Frederik Hvas, Christian Lodberg Licht, Tine Rask
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Gut Microbes
In fecal microbiota transplantation (FMT) against recurrent Clostridioides difficile infection (CDI), clinical outcomes are usually determined after 8 weeks. We hypothesized that the intestinal microbiota changes earlier than this timepoint, and analyzed fecal samples obtained 1 week after treatment from 64 patients diagnosed with recurrent CDI and...
Kastl, Arthur Zong, Wenjing Gershuni, Victoria M. Friedman, Elliot S. Tanes, Ceylan Boateng, Adoma Mitchell, William J. O’Connor, Kathleen Bittinger, Kyle Terry, Natalie A.
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Gut Microbes
Complications of short bowel syndrome (SBS) include malabsorption and bacterial overgrowth, requiring prolonged dependence on parenteral nutrition (PN). We hypothesized that the intolerance of whole food in some SBS patients might be due to the effect of dietary fiber on the gut microbiome. Shotgun metagenomic sequencing and targeted metabolomics w...
Lavelle, Aonghus Nancey, Stéphane Reimund, Jean-Marie Laharie, David Marteau, Philippe Treton, Xavier Allez, Matthieu Roblin, Xavier Malamut, Georgia Oeuvray, Cyriane
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Gut microbes
Due to the potential role of the gut microbiota and bile acids in the pathogenesis of both inflammatory bowel disease (IBD) and sporadic colorectal cancer, we aimed to determine whether these factors were associated with colorectal cancer in IBD patients. 215 IBD patients and 51 non-IBD control subjects were enrolled from 10 French IBD centers betw...
Schmiester, Maren Maier, René Riedel, René Durek, Pawel Frentsch, Marco Kolling, Stefan Mashreghi, Mir-Farzin Jenq, Robert Zhang, Liangliang Peterson, Christine B.
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Gut Microbes
Modulation of commensal gut microbiota is increasingly recognized as a promising strategy to reduce mortality in patients with malignant diseases, but monitoring for dysbiosis is generally not routine clinical practice due to equipment, expertise and funding required for sequencing analysis. A low-threshold alternative is microbial diversity profil...
