Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study.
Published in Gut
NCT01452763; NCT01456247.
CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic li...
...Published in Gut
Immunosuppressive CD14+HLA-DR- M-MDSCs are expanded in patients with ACLF. They were depicted by suppressing T cell function, attenuated antimicrobial innate immune responses, linked to secondary infection, disease severity and prognosis. TLR-3 agonism reversed M-MDSC expansion and innate immune function and merits further evaluation as potential i...
miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.
...Published in Gut
Our findings identify miR-132 as a key regulator of hepatic lipid homeostasis, functioning in a context-dependent fashion via suppression of multiple targets and with cumulative synergistic effects. This indicates reduction of miR-132 levels as a possible treatment of hepatic steatosis.
Mucosal microbiome dysbiosis in gastric carcinogenesis.
...Published in Gut
In addition to microbial compositional changes, we identified differences in bacterial interactions across stages of gastric carcinogenesis. The significant enrichments and network centralities suggest potentially important roles of P. stomatis, D. pneumosintes, S. exigua, P. micra and S. anginosus in GC progression.
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilit...
...Published in Gut
VAP-1 expression is increased in PSC, facilitates adhesion of gut-tropic lymphocytes to liver endothelium in a substrate-dependent manner, and elevated levels of its circulating form predict clinical outcome in patients.
Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority...
Published in Gut
NCT01452750, NCT01456260; Results.
Oesophageal cancer incidence in 20-year follow-up in a population-based sample of 12 000 middle-age men with or without ...
Published in Gut
Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chem...
...Published in Gut
Dual targeting of CCR2+ TAM and CXCR2+ TAN improves antitumour immunity and chemotherapeutic response in PDAC compared with either strategy alone.
Protein and glycomic plasma markers for early detection of adenoma and colon cancer.
...Published in Gut
A panel including BAG4, IL6ST, VWF, EGFR and CD44 protein/glycomics performed well for detection of early stages of colon cancer and should be further examined in larger studies.
Plasma ghrelin is probably not a useful biomarker for risk prediction or early detection of colorectal cancer.
Published in Gut
