Voskens, Caroline Stoica, Diane Rosenberg, Marita Vitali, Francesco Zundler, Sebastian Ganslmayer, Marion Knott, Heike Wiesinger, Manuel Wunder, Jutta Kummer, Mirko
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Published in
Gut
Ulcerative colitis (UC) is a chronic, debilitating immune-mediated disease driven by disturbed mucosal homeostasis, with an excess of intestinal effector T cells and an insufficient expansion of mucosal regulatory T cells (Tregs). We here report on the successful adoptive transfer of autologous, ex vivo expanded Tregs in a patient with refractory U...
Esteves, A Raquel Munoz-Pinto, Mário F Nunes-Costa, Daniela Candeias, Emanuel Silva, Diana F Magalhães, João D Pereira-Santos, A Raquel Ferreira, I Luisa Alarico, Susana Tiago, Igor
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Published in
Gut
Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the ...
Sachan, Anurag Mandavdhare, Harshal S
Published in
Gut
Vitale, Alessandro Svegliati-Baroni, Gianluca Ortolani, Alessio Cucco, Monica Dalla Riva, Giulio V Giannini, Edoardo G Piscaglia, Fabio Rapaccini, Gianludovico Di Marco, Mariella Caturelli, Eugenio
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Published in
Gut
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort. We analyse...
Jess, Tine Vestergaard, Marie V Iversen, Aske T Allin, Kristine Højgaard
Published in
Gut
Lou, Haiyi Xie, Bo Wang, Yimin Gao, Yang Xu, Shuhua
Published in
Gut
Inoue, Genki Yamamoto, Shuji Koh, Nobuo Kuwada, Takeshi Nakanishi, Yuki Takahashi, Ken Seno, Hiroshi
Published in
Gut
Effenberger, Maria Widjaja, Anissa A Grabherr, Felix Schaefer, Benedikt Grander, Christoph Mayr, Lisa Schwaerzler, Julian Enrich, Barbara Moser, Patrizia Fink, Julia
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Published in
Gut
Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory cytokine with increasingly recognised toxicities in parenchymal and epithelial cells. We explored IL-11 serum levels and their prognostic value in patients suffe...
Hernaez, Ruben Peck-Radosavljevic, Markus
Published in
Gut
Zhang, Chao Li, Jiesheng Cheng, Yongqian Meng, Fanping Song, Jin-Wen Fan, Xing Fan, Hongtao Li, Jing Fu, Yu-Long Zhou, Ming-Ju
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Published in
Gut
A comprehensive immune landscape for HBV infection is pivotal to achieve HBV cure. We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired liver and blood samples of 23 individuals, including six immune tolerant, 5 immune active (IA), 3 acute recovery (AR), 3 chronic resolved and 6 HBV-free healthy controls (HCs). Flow cytometry an...