Multicentre prospective study of COVID-19 transmission following outpatient GI endoscopy in the UK.
Published in Gut
Aggressive case of early onset gastric cancer; identifying the knowledge gap.
Published in Gut
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
...Published in Gut
ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC). Combinational synergy screening was performed to endeavour a genotype-tailored targeted therapy. Synergy was found on inhibition of PARP, ATR and DNA-PKcs (PAD) leading to ...
Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcom...
Published in Gut
Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's disease (CD), including their impact on ...
Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites.
...Published in Gut
Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD-HCC through modulating gut microbiota and its metabolites. High-fat/high-cholesterol (HFHC), high-fat/low-cholesterol or normal chow diet was fed to C57BL/6 ma...
Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom.
Published in Gut
To generate real-world evidence for the epidemiology of gastroparesis in the UK, we evaluated the prevalence, incidence, patient characteristics and outcomes of gastroparesis in the Clinical Practice Research Datalink (CPRD) database. This was a retrospective, cross-sectional study. Prevalence and incidence of gastroparesis were evaluated in the CP...
Effect of IBD medications on COVID-19 outcomes: results from an international registry.
...Published in Gut
We sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations. Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19. We used ...
Dysphagia in a young female patient: it's not always that simple.
Published in Gut
Involvement of liver in COVID-19: systematic review and meta-analysis.
...Published in Gut
Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in ...
Published in Gut
The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear. We generated 42 lines of human and murine organoids fro...
