Sharma, Mamta Hegde, Prajna Hiremath, Kavita Reddy H, Vishwanath Kamalanathan, A S Swamy, Bale M Inamdar, Shashikala R
Published in
Glycoconjugate journal
Plant lectins are gaining interest because of their interesting biological properties. Several Adenia species, that are being used in traditional medicine to treat many health ailments have shown presence of lectins or carbohydrate binding proteins. Here, we report the purification, characterization and biological significance of N-Acetyl galactosa...
Sonnino, Sandro Prinetti, Alessandro
Published in
Glycoconjugate journal
Shubhakar, Archana Pang, Poh-Choo Fernandes, Daryl L Dell, Anne Spencer, Daniel I R Haslam, Stuart M
Published in
Glycoconjugate journal
Glycosylation is considered one of the most complex and structurally diverse post-translational modifications of proteins. Glycans play important roles in many biological processes such as protein folding, regulation of protein stability, solubility and serum half-life. One of the ways to study glycosylation is systematic structural characterizatio...
Kizuka, Yasuhiko Taniguchi, Naoyuki
Published in
Glycoconjugate journal
Bisecting GlcNAc, a branch structure in N-glycan, has unique functions and is involved in several diseases including Alzheimer's disease (AD). In this review, we provide an overview of the biosynthesis of bisecting GlcNAc and its physiological and pathological functions, particularly in the nervous system where bisecting GlcNAc is most highly expre...
Guo, Bi-Shan Zheng, Feng Crouch, Lucy Cai, Zhi-Peng Wang, Meng Bolam, David N Liu, Li Voglmeir, Josef
Published in
Glycoconjugate journal
A putative GH35 β-galactosidase gene from the mucin-degrading bacterium Akkermansia muciniphila was successfully cloned and further investigated. The recombinant enzyme with the molecular mass of 74 kDa was purified to homogeneity and biochemically characterised. The optimum temperature of the enzyme was 42 °C, and the optimum pH was determined to ...
Chiricozzi, Elena Mauri, Laura Ciampa, Maria Grazia Prinetti, Alessandro Sonnino, Sandro
Published in
Glycoconjugate journal
Link-Lenczowski, Paweł Bubka, Monika Balog, Crina I A Koeleman, Carolien A M Butters, Terry D Wuhrer, Manfred Lityńska, Anna
Published in
Glycoconjugate journal
N-acetylglucosaminyltransferase III (GnT-III) is known to catalyze N-glycan "bisection" and thereby modulate the formation of highly branched complex structures within the Golgi apparatus. While active, it inhibits the action of other GlcNAc transferases such as GnT-IV and GnT-V. Moreover, GnT-III is considered as an inhibitor of the metastatic pot...
Breimer, Michael E Säljö, Karin Barone, Angela Teneberg, Susann
Published in
Glycoconjugate journal
The application of human stem cell technology offers theoretically a great potential to treat various human diseases. However, to achieve this goal a large number of scientific issues remain to be solved. Cell surface carbohydrate antigens are involved in a number of biomedical phenomena that are important in clinical applications of stem cells, su...
Ho, Ming-Yi Yu, Alice L Yu, John
Published in
Glycoconjugate journal
Glycosphingolipids (GSLs) are composed of complex glycans linked to sphingosines and various fatty acid chains. Antibodies against several GSLs designated as stage-specific embryonic antigens (SSEAs), have been widely used to characterize differentiation of embryonic stem (ES) cells. In view of the cross-reactivities of these antibodies with multip...
Muramatsu, Takashi
Published in
Glycoconjugate journal
Embryonal carcinoma cells, stem cells of teratocarcinomas, are pluripotent stem cells and also prototypes of embryonic stem cells. Embryonal carcinoma cells contain large amounts of a highly branched poly-N-acetyllactosamine called embryoglycan, which has a molecular weight of approximately 10,000 or greater, and is asparagine-linked. This glycan w...
