Tanaka, Kyoko Suzuki, Akemi Aoki, Daisuke Iwamori, Masao
Published in
Glycoconjugate Journal
Humanized monoclonal antibody HMMC-1 established by immunizing transchromosomal mice with a human uterine endometrial cancer cell line has been found to react with the H-antigen carried on core l O-glycans through cotransfection of glycosyltransferases for O-glycans and inhibition of antibody-binding with synthetic oligosaccharides. However, direct...
Hof, Danique J. Versteeg, Elly M. M. van de Lest, Chris H. A. Daamen, Willeke F. van Kuppevelt, Toin H.
Published in
Glycoconjugate Journal
Glycosaminoglycans (GAGs) are known to play pivotal roles in physiological processes and pathological conditions. To study interactions of GAGs with proteins, immobilization of GAGs is often required. Current methodologies for immobilization involve modification of GAGs and/or surfaces, which can be time-consuming and may involve specialized equipm...
Oh, So-Young Park, Myeong-Soo Lee, Yeong-Geun Thi, Nhan Nguyen Baek, Nam-In Ji, Geun-Eog
Published in
Glycoconjugate Journal
Breast-fed infants have Bifidobacterium-rich gut microbiota compared to infants fed formula. Fucosylated oligosaccharides are the major components of human milk oligosaccharide (HMO) which confer various beneficial effects including prebiotic effect and protection from pathogenic infection on the host. A novel prebiotics was developed using bifidob...
Du, Jiayan Liu, Su Liang, Quntao Lin, Jianghui Jiang, Lilong Chen, Fener Wei, Zheng
Published in
Glycoconjugate Journal
Colla corii asini (CCA) made from donkey-hide has been widely used as a health-care food and an ingredient of traditional Chinese medicine. Heparan sulfate (HS)/heparin is a structurally complex class of glycosaminoglycans (GAGs) that have been implicated in a wide range of biological activities. However, their presence within CCA, and their possib...
Matsuoka, Yuko Kawauchi, Yoko Kawauchi, Kiyotaka Takiyama, Akari Kojima, Shohei Kuroda, Yasuhiro Kojima, Naoya
Published in
Glycoconjugate Journal
In this study, we assessed the potential of liposomes coated with a neoglycolipid containing α1–3,α1–6-mannotriose residues (Man3-DPPE; Manα1–6(Manα1–3)Manitol-DPPE) for in vitro activation and maturation of human mononuclear phagocytes. In response to treatment with Man3-DPPE-coated liposomes (Man3-OMLs), PMA-stimulated human THP-1 cells showed en...
Wu, Albert M. Liu, Jia Hau
Published in
Glycoconjugate Journal
Lectins, in combination with our established enzyme-linked lectin sorbent assay (ELLSA) and inhibition study, have been used as powerful tools in many glycoconjugate recognition studies. In this short review, we highlight the following: (i) The recognition profiles of Gal/GalNAc-specific lectins were updated and upgraded. (ii) Based on the cross-sp...
Kim, So Young Kundu, Joydip Williams, Asher Yandulskaya, Anastasia S. Monaghan, James R. Carrier, Rebecca L. Linhardt, Robert J.
Published in
Glycoconjugate Journal
Retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are major causes of blindness worldwide. Humans cannot regenerate retina, however, axolotl (Ambystoma mexicanum), a laboratory-bred salamander, can regenerate retinal tissue throughout adulthood. Classic signaling pathways, including fibrobl...
Lee, Sindre Kolset, Svein O. Birkeland, Kåre I. Drevon, Christian A. Reine, Trine M.
Published in
Glycoconjugate Journal
The effects of acute and long-term exercise on syndecans and the relationship to insulin sensitivity are not fully explored. We aimed to examine the effects of acute and 12 weeks of exercise on (1) serum levels of syndecan-1 and -4, (2) gene expression related to syndecan synthesis and modification in skeletal muscle and adipose tissue, and (3) the...
Silsirivanit, Atit Phoomak, Chatchai Teeravirote, Karuntarat Wattanavises, Sasiprapa Seubwai, Wunchana Saengboonmee, Charupong Zhan, Zhaoqi Inokuchi, Jin-ichi Suzuki, Akemi Wongkham, Sopit
...
Published in
Glycoconjugate Journal
Alteration of glycosphingolipid (GSL) synthesis is observed in many types of cancer. In this study, we have analyzed the expression of sphingolipids and GSLs in cholangiocarcinoma (CCA) tissues and adjacent normal liver tissues. Neutral lipids were extracted from tissue samples using mild-alkaline treatment method followed by TLC and LC-MS analysis...
Zhang, Pei Dai, Hong Peng, Lei
Published in
Glycoconjugate Journal
Epithelial-mesenchymal transition (EMT) in peritoneum was induced during peritoneal dialysis (PD), which finally caused progressive fibrosis. However, the underlying mechanisms were not well elucidated. We established advanced glycation end-products (AGEs)-induced EMT model using primary human peritoneal mesothelial cells (HPMCs). The working conce...
