The Elements of Data Sharing.
Published in Genomics, proteomics & bioinformatics
Multi-omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratumoral Phenotypic Dive...
...Published in Genomics, proteomics & bioinformatics
Uncovering the functionally essential variations related to tumorigenesis and tumor progression from cancer genomics data is still challenging due to the genetic diversity among patients, and extensive inter- and intra-tumoral heterogeneity at different levels of gene expression regulation, including but not limited to the genomic, epigenomic, and ...
PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders.
...Published in Genomics, proteomics & bioinformatics
De novo variants (DNVs) are one of the most significant contributors to severe early-onset genetic disorders such as autism spectrum disorder, intellectual disability, and other developmental and neuropsychiatric (DNP) disorders. Presently, a plethora of DNVs have been identified using next-generation sequencing, and many efforts have been made to ...
Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation.
Published in Genomics, proteomics & bioinformatics
Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collectio...
Big Data and the Brain: Peeking at the Future.
Published in Genomics, proteomics & bioinformatics
GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis.
Published in Genomics, proteomics & bioinformatics
Gliomas are one of the most common types of brain cancers. Numerous efforts have been devoted to studying the mechanisms of glioma genesis and identifying biomarkers for diagnosis and treatment. To help further investigations, we present a comprehensive database named GliomaDB. GliomaDB includes 21,439 samples from 4304 patients and integrates geno...
Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs.
...Published in Genomics, proteomics & bioinformatics
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches. Previously, we published high-throughput sequencing based ...
Functional Neuroimaging in the New Era of Big Data.
Published in Genomics, proteomics & bioinformatics
The field of functional neuroimaging has substantially advanced as a big data science in the past decade, thanks to international collaborative projects and community efforts. Here we conducted a literature review on functional neuroimaging, with focus on three general challenges in big data tasks: data collection and sharing, data infrastructure c...
Deciphering Brain Complexity Using Single-cell Sequencing.
Published in Genomics, proteomics & bioinformatics
The human brain contains billions of highly differentiated and interconnected cells that form intricate neural networks and collectively control the physical activities and high-level cognitive functions, such as memory, decision-making, and social behavior. Big data is required to decipher the complexity of cell types, as well as connectivity and ...
DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening.
...Published in Genomics, proteomics & bioinformatics
Accurate identification of compound-protein interactions (CPIs) in silico may deepen our understanding of the underlying mechanisms of drug action and thus remarkably facilitate drug discovery and development. Conventional similarity- or docking-based computational methods for predicting CPIs rarely exploit latent features from currently available ...
