Zhao, Zheng Zhang, Ke-Nan Wang, Qiangwei Li, Guanzhang Zeng, Fan Zhang, Ying Wu, Fan Chai, Ruichao Wang, Zheng Zhang, Chuanbao
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Published in
Genomics, proteomics & bioinformatics
Gliomas are the most common and malignant intracranial tumors in adults. Recent studies have revealed the significance of functional genomics for glioma pathophysiological studies and treatments. However, access to comprehensive genomic data and analytical platforms is often limited. Here, we developed the Chinese Glioma Genome Atlas (CGGA), a user...
Xing, Xiaohua Yuan, Hui Liu, Hongzhi Tan, Xionghong Zhao, Bixing Wang, Yingchao Ouyang, Jiahe Lin, Minjie Liu, Xiaolong Huang, Aimin
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Published in
Genomics, proteomics & bioinformatics
Early detection and intervention are key strategies to reduce mortality, increase long-term survival, and improve the therapeutic effects of hepatocellular carcinoma (HCC) patients. Herein, the isobaric tag for relative and absolute quantitation (iTRAQ)-based quantitative proteomic strategy was used to study the secretomes in conditioned media from...
Song, Guang Lee, Emily M Pan, Jianbo Xu, Miao Rho, Hee-Sool Cheng, Yichen Whitt, Nadia Yang, Shu Kouznetsova, Jennifer Klumpp-Thomas, Carleen
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Published in
Genomics, proteomics & bioinformatics
The Zika virus (ZIKV) and dengue virus (DENV) flaviviruses exhibit similar replicative processes but have distinct clinical outcomes. A systematic understanding of virus-host protein-protein interaction networks can reveal cellular pathways critical to viral replication and disease pathogenesis. Here we employed three independent systems biology ap...
Shen, Boyan Chen, Zhaoming Yu, Chunyu Chen, Taoyu Shi, Minglei Li, Tingting
Published in
Genomics, proteomics & bioinformatics
Phase separation is an important mechanism that mediates the compartmentalization of proteins in cells. Proteins that can undergo phase separation in cells share certain typical sequence features, like intrinsically disordered regions (IDRs) and multiple modular domains. Sequence-based analysis tools are commonly used in the screening of these prot...
Wang, Feiyang Jia, Wentong Fan, Mengjie Shao, Xuan Li, Zhilang Liu, Yongjie Ma, Yeling Li, Yu-Xia Li, Rong Tu, Qiang
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Genomics, proteomics & bioinformatics
Successful pregnancy in placental mammals substantially depends on the establishment of maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly associated with adverse pregnancy outcomes including recurrent miscarriage (RM). However, an in-depth understanding of the systematic and decidual immune environment in ...
Song, Shuhui Ma, Lina Zou, Dong Tian, Dongmei Li, Cuiping Zhu, Junwei Chen, Meili Wang, Anke Ma, Yingke Li, Mengwei
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Published in
Genomics, proteomics & bioinformatics
On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-C...
Yao, Guocai Zhang, Wenliang Yang, Minglei Yang, Huan Wang, Jianbo Zhang, Haiyue Wei, Lai Xie, Zhi Li, Weizhong
Published in
Genomics, proteomics & bioinformatics
Microbes play important roles in human health and disease. The interaction between microbes and hosts is a reciprocal relationship, which remains largely under-explored. Current computational resources lack manually and consistently curated data to connect metagenomic data to pathogenic microbes, microbial core genes, and disease phenotypes. We dev...
Teng, Xufei Li, Qianpeng Li, Zhao Zhang, Yuansheng Niu, Guangyi Xiao, Jingfa Yu, Jun Zhang, Zhang Song, Shuhui
Published in
Genomics, proteomics & bioinformatics
COVID-19 and its causative pathogen SARS-CoV-2 have rushed the world into a staggering pandemic in a few months, and a global fight against both has been intensifying. Here, we describe an analysis procedure where genome composition and its variables are related, through the genetic code to molecular mechanisms, based on understanding of RNA replic...
Li, Ting Chen, Bing Yang, Pengcheng Wang, Depin Du, Baozhen Kang, Le
Published in
Genomics, proteomics & bioinformatics
Long non-coding RNAs (lncRNAs) regulate various biological processes ranging from gene expression to animal behavior. Although protein-coding genes, microRNAs, and neuropeptides play important roles in the regulation of phenotypic plasticity in migratory locust, empirical studies on the function of lncRNAs in this process remain limited. Here, we a...
Liu, Qi Zhao, Shilei Shi, Cheng-Min Song, Shuhui Zhu, Sihui Su, Yankai Zhao, Wenming Li, Mingkun Bao, Yiming Xue, Yongbiao
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Published in
Genomics, proteomics & bioinformatics
A novel RNA virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the ongoing outbreak of coronavirus disease 2019 (COVID-19). Population genetic analysis could be useful for investigating the origin and evolutionary dynamics of COVID-19. However, due to extensive sampling bias and existence of infection cluste...
