Alemu, Setegn Worku Bijma, Piter Calus, Mario P. L. Liu, Huiming Fernando, Rohan L. Dekkers, Jack C. M.
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Genetics Selection Evolution
BackgroundLinkage disequilibrium (LD) is commonly measured based on the squared coefficient of correlation r2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left({r}^{...
Casu, Sara Usai, Mario Graziano Sechi, Tiziana Salaris, Sotero L. Miari, Sabrina Mulas, Giuliana Tamponi, Claudia Varcasia, Antonio Scala, Antonio Carta, Antonello
...
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Genetics Selection Evolution
BackgroundGastroinestinal nematodes (GIN) are one of the major health problem in grazing sheep. Although genetic variability of the resistance to GIN has been documented, traditional selection is hampered by the difficulty of recording phenotypes, usually fecal egg count (FEC). To identify causative mutations or markers in linkage disequilibrium (L...
Cheng, Jian Lim, KyuSang Putz, Austin M. Wolc, Anna Harding, John C. S. Dyck, Michael K. Fortin, Frederic Plastow, Graham S. Dekkers, Jack C. M.
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Genetics Selection Evolution
BackgroundDisease resilience is the ability to maintain performance across environments with different disease challenge loads (CL). A reaction norm describes the phenotypes that a genotype can produce across a range of environments and can be implemented using random regression models. The objectives of this study were to: (1) develop measures of ...
Signer-Hasler, Heidi Henkel, Jan Bangerter, Erika Bulut, Zafer Drögemüller, Cord Leeb, Tosso Flury, Christine
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Genetics Selection Evolution
BackgroundThe domestication of goat (Capra hircus) started 11,000 years ago in the fertile crescent. Breed formation in the nineteenth century, establishment of herd books, and selection for specific traits resulted in 10 modern goat breeds in Switzerland. We analyzed whole-genome sequencing (WGS) data from 217 modern goats and nine wild Bezoar goa...
Ablondi, Michela Johnsson, Martin Eriksson, Susanne Sabbioni, Alberto Viklund, Åsa Gelinder Mikko, Sofia
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Genetics Selection Evolution
BackgroundWarmblood fragile foal syndrome (WFFS) is a monogenetic defect caused by a recessive lethal missense point mutation in the procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 1 gene (PLOD1, c.2032G>A). The majority of homozygous WFFS horses are aborted during gestation. Clinical signs of affected horses include fragile skin, skin and mucosa ...
Gianola, Daniel Cantet, Rodolfo J. Dekkers, Jack C. M. Pérez-Enciso, Miguel
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Genetics Selection Evolution
Sell-Kubiak, Ewa Knol, Egbert F. Lopes, Marcos
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Genetics Selection Evolution
BackgroundThe genetic background of trait variability has captured the interest of ecologists and animal breeders because the genes that control it could be involved in buffering various environmental effects. Phenotypic variability of a given trait can be assessed by studying the heterogeneity of the residual variance, and the quantitative trait l...
Reynolds, Edwardo G. M. Lopdell, Thomas Wang, Yu Tiplady, Kathryn M. Harland, Chad S. Johnson, Thomas J. J. Neeley, Catherine Carnie, Katie Sherlock, Richard G. Couldrey, Christine
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Published in
Genetics Selection Evolution
BackgroundDeleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious recessive mutations with large effects were discovered via non-additive genome-wide association studies (GWAS) of quantitative growth and developmental traits in cattle, which showed that quantitative traits can...
Magris, Gabriele Marroni, Fabio D’Agaro, Edo Vischi, Massimo Chiabà, Cristina Scaglione, Davide Kijas, James Messina, Maria Tibaldi, Emilio Morgante, Michele
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Genetics Selection Evolution
BackgroundBrown trout is one of the most widespread fresh-water fish species in Europe. The evolutionary history of and phylogenetic relationships between brown trout populations are complex, and this is especially true for Italian populations, which are heavily influenced in different ways by stocking practices. The characterization of the genetic...
Ballan, Mohamad Bovo, Samuele Schiavo, Giuseppina Schiavitto, Michele Negrini, Riccardo Fontanesi, Luca
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Genetics Selection Evolution
BackgroundDomestication of the rabbit (Oryctolagus cuniculus) has led to a multi-purpose species that includes many breeds and lines with a broad phenotypic diversity, mainly for external traits (e.g. coat colours and patterns, fur structure, and morphometric traits) that are valued by fancy rabbit breeders. As a consequence of this human-driven se...
