Corrigendum to: Genetic evaluation including intermediate omics features.
Published in Genetics
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Published in Genetics
Atherosclerosis is the underlying cause of heart attack, ischemic stroke and peripheral arterial disease, and genetic factors involved remain mostly unidentified. We previously identified a significant locus on mouse chromosome 17 for atherosclerosis, Ath49, in an intercross between BALB/c and SM strains. Ath49 partially overlaps in the confidence ...
Two promoters integrate multiple enhancer inputs to drive wild-type knirps expression in the Drosophila melanogaster emb...
Published in Genetics
Proper development depends on precise spatiotemporal gene expression patterns. Most developmental genes are regulated by multiple enhancers and often by multiple core promoters that generate similar transcripts. We hypothesize that multiple promoters may be required either because enhancers prefer a specific promoter or because multiple promoters s...
Sporadic occurrence of recent selective sweeps from standing variation in humans as revealed by an approximate Bayesian ...
Published in Genetics
During their dispersals over the last 100,000 years, modern humans have been exposed to a large variety of environments, resulting in genetic adaptation. While genome-wide scans for the footprints of positive Darwinian selection have increased knowledge of genes and functions potentially involved in human local adaptation, they have globally produc...
CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans.
Published in Genetics
Interactions among proteins are fundamental for life and determining whether two particular proteins physically interact can be essential for fully understanding a protein's function. We present Caenorhabditis elegans light-induced coclustering (CeLINC), an optical binary protein-protein interaction assay to determine whether two proteins interact ...
The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in discrimination of close...
Published in Genetics
Most sexually reproducing organisms have the ability to recognize individuals of the same species. In ascomycete fungi including yeasts, mating between cells of opposite mating type depends on the molecular recognition of two peptidyl mating pheromones by their corresponding G-protein coupled receptors (GPCRs). Although such pheromone/receptor syst...
Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks.
Published in Genetics
Mutations in enhancers have been shown to often underlie natural variation but the evolved differences in enhancer activity can be difficult to identify in vivo. Threespine sticklebacks (Gasterosteus aculeatus) are a robust system for studying enhancer evolution due to abundant natural genetic variation, a diversity of evolved phenotypes between an...
Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by m...
Published in Genetics
Genetic correlations between traits may cause correlated responses to selection. Previous models described the conditions under which genetic correlations are expected to be maintained. Selection, mutation, and migration are all proposed to affect genetic correlations, regardless of whether the underlying genetic architecture consists of pleiotropi...
TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.
Published in Genetics
Cdk8 of the RNA polymerase II mediator kinase complex regulates gene expression by phosphorylating sequence-specific transcription factors. This function is conserved amongst eukaryotes, but the signals and mechanisms regulating Cdk8 activity and phosphorylation of its substrates are unknown. Full induction of the GAL genes in yeast requires phosph...
Corrigendum to: Chemosensory signal transduction in Caenorhabditis elegans.
Published in Genetics
