Uchino, Kaori Vu Quang, Lam Mizuno, Shohei Horio, Tomohiro Yamamoto, Hidesuke Hanamura, Ichiro Kodera, Yoshihisa Luis Espinoza, J. Onizuka, Makoto Kashiwase, Koichi
...
Published in
Genes and Immunity
UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory proces...
Hussain, Irfan Pervaiz, Nashaiman Khan, Abbas Saleem, Shoaib Shireen, Huma Wei, Dong-Qing Labrie, Viviane Bao, Yiming Abbasi, Amir Ali
Published in
Genes and Immunity
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading fast worldwide. There is a pressing need to understand how the virus counteracts host innate immune responses. Deleterious clinical manifestations of coronaviruses have been associated with virus-induced direct dys...
Glinos, Dafni A. Soskic, Blagoje Williams, Cayman Kennedy, Alan Jostins, Luke Sansom, David M. Trynka, Gosia
Published in
Genes and Immunity
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are more sensitive to CD28 costimulation than naive T cells. T...
Bourdon, Marie Manet, Caroline Montagutelli, Xavier
The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, whic...
Galicia, Johnah C. Guzzi, Pietro H. Giorgi, Federico M. Khan, Asma A.
Published in
Genes and Immunity
Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and it...
Madhu, Bhoomi Lakdawala, Mohammed Farhan Issac, Neethu G. Gumienny, Tina L.
Published in
Genes and Immunity
Animals counter specific environmental challenges with a combination of broad and tailored host responses. One protein family enlisted in the innate immune response includes the saposin-like antimicrobial proteins. We investigated the expression of a Caenorhabditis elegans saposin-like gene, spp-9 , in response to different stresses. spp-9 expressi...
Kappler, Katharina Hennet, Thierry
Published in
Genes and Immunity
Carbohydrate-specific antibodies are widespread among all classes of immunoglobulins. Despite their broad occurrence, little is known about their formation and biological significance. Carbohydrate-specific antibodies are often classified as natural antibodies under the assumption that they arise without prior exposure to exogenous antigens. On the...
Carter, Tonia C. Ye, Zhan Ivacic, Lynn C. Budi, Noah Rose, Warren E. Shukla, Sanjay K.
Published in
Genes and Immunity
Host genetic variation may be a contributing factor to variability in Staphylococcus aureus bacteremia duration. We assessed whether 28 single nucleotide polymorphisms (SNPs) in seven genes ( TLR2 , TLR4 , TIRAP , IRAK4 , TRAF6, NOD2 , and CISH ) that mediate host immune response were associated with S. aureus bacteremia duration. Subjects included...
Dhande, Isha S. Kneedler, Sterling C. Zhu, Yaming Joshi, Aniket S. Hicks, M. John Wenderfer, Scott E. Braun, Michael C. Doris, Peter A.
Published in
Genes and Immunity
Similar to humans, the risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study, we show the involvement of genetic variation affecting the store-operated calcium signaling gene, Stim1 , in the pathogenesis of stroke in SHR. Stim1 is a key ...
Heeb, Lukas E. M. Egholm, Cecilie Boyman, Onur
Published in
Genes and Immunity
The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins. Activation of epithelial and myeloid cells, and a transient neutrophils influx initiates type 2 immune responses, which are dominated by basophils, eosinophils, mast cells, B cell immunoglobulin E produ...
