Mona, Bishakha Villarreal, Juan Savage, Trisha K Kollipara, Rahul K Boisvert, Brooke E Johnson, Jane E
Published in
Genes & development
Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor essential in dorsal neural tube progenitors for specification of these inhibitory neurons. Thus, mechanisms regulating Ptf1a expression are key for generating neuronal circuits underlying soma...
Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Beebe, Katherine Robins, Marcy M Hernandez, Edgar J Lam, Geanette Horner, Michael A Thummel, Carl S
Published in
Genes & development
Metabolism and development must be closely coupled to meet the changing physiological needs of each stage in the life cycle. The molecular mechanisms that link these pathways, however, remain poorly understood. Here we show that the Drosophila estrogen-related receptor (dERR) directs a transcriptional switch in mid-pupae that promotes glucose oxida...
Lu, Dan Sin, Ho-Su Lu, Chenggang Fuller, Margaret T
Published in
Genes & development
Cell type-specific transcriptional programs that drive differentiation of specialized cell types are key players in development and tissue regeneration. One of the most dramatic changes in the transcription program in Drosophila occurs with the transition from proliferating spermatogonia to differentiating spermatocytes, with >3000 genes either new...
Xiao, Yang Hill, Matthew C Li, Lele Deshmukh, Vaibhav Martin, Thomas J Wang, Jun Martin, James F
Published in
Genes & development
Cardiac fibroblasts (CFs) respond to injury by transitioning through multiple cell states, including resting CFs, activated CFs, and myofibroblasts. We report here that Hippo signaling cell-autonomously regulates CF fate transitions and proliferation, and non-cell-autonomously regulates both myeloid and CF activation in the heart. Conditional delet...
Gable, Dustin L Gaysinskaya, Valeriya Atik, Christine C Talbot, C Conover Jr Kang, Byunghak Stanley, Susan E Pugh, Elizabeth W Amat-Codina, Nuria Schenk, Kara M Arcasoy, Murat O
...
Published in
Genes & development
Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to identify heterozygous loss of function of ZCCHC8, a zinc-knuckle containing protein, as a cause of autosomal dominant pulmonary fibrosis. ZCCHC8 associated with TR and was required for telom...
Mermet, Jérôme Yeung, Jake Hurni, Clémence Mauvoisin, Daniel Gustafson, Kyle Jouffe, Céline Nicolas, Damien Emmenegger, Yann Gobet, Cédric Franken, Paul
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Published in
Genes & development
The circadian clock in animals orchestrates widespread oscillatory gene expression programs, which underlie 24-h rhythms in behavior and physiology. Several studies have shown the possible roles of transcription factors and chromatin marks in controlling cyclic gene expression. However, how daily active enhancers modulate rhythmic gene transcriptio...
Su, Yulong Pelz, Carl Huang, Tao Torkenczy, Kristof Wang, Xiaoyan Cherry, Allison Daniel, Colin J Liang, Juan Nan, Xiaolin Dai, Mu-Shui
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Published in
Genes & development
The transcription factor MYC (also c-Myc) induces histone modification, chromatin remodeling, and the release of paused RNA polymerase to broadly regulate transcription. MYC is subject to a series of post-translational modifications that affect its stability and oncogenic activity, but how these control MYC's function on the genome is largely unkno...
Vuolo, Francesco Kierzkowski, Daniel Runions, Adam Hajheidari, Mohsen Mentink, Remco A Gupta, Mainak Das Zhang, Zhongjuan Vlad, Daniela Wang, Yi Pecinka, Ales
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Published in
Genes & development
How the interplay between cell- and tissue-level processes produces correctly proportioned organs is a key problem in biology. In plants, the relative size of leaves compared with their lateral appendages, called stipules, varies tremendously throughout development and evolution, yet relevant mechanisms remain unknown. Here we use genetics, live im...
Hong, Hee-Kyung Maury, Eleonore Ramsey, Kathryn Moynihan Perelis, Mark Marcheva, Biliana Omura, Chiaki Kobayashi, Yumiko Guttridge, Denis C Barish, Grant D Bass, Joseph
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Published in
Genes & development
The mammalian circadian clock is encoded by an autoregulatory transcription feedback loop that drives rhythmic behavior and gene expression in the brain and peripheral tissues. Transcriptomic analyses indicate cell type-specific effects of circadian cycles on rhythmic physiology, although how clock cycles respond to environmental stimuli remains in...
