de Sousa, Bruno Rafael Virginio de Lima Tavares Toscano, Lydiane de Almeida Filho, Eder Jackson Bezerra Sena, Klécia Farias Costa, Matheus Silveira de Souza Cunha, Rebeka Correia de Souza Siqueira Quintans, Jullyana Heimfarth, Luana Marques, Aline Telles Biasoto da Silva, Darcilene Fiuza
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Genes & Nutrition
Background We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Methods Forty-seven male recreational runners ...
Wang, Tianyi Cheng, Jun Wang, Yanggan
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Genes & nutrition
Atrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atrial fibrillation. However, the causal relationship between iron status and AF remains unclear. The purpose of this investigation was to use Mendelian randomization (MR) analysis, which has been widely applied to e...
Krstic, Nevena Bishop, Nick Curtis, Beth Cooper, Cyrus Harvey, Nick Lilycrop, Karen Murray, Robert Owen, Robert Reilly, Gwen Skerry, Tim
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Genes & nutrition
Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementation leads to reduced RXRA DNA methylation. Mice exposed to early life vitamin D deficiency have reduced bone mass and bone accrual in response ...
Khamis, Abeer A. Ibrahim, Rana M. El-hefnawy, Gad B. Ibrahim, Wafaa M. Ali, Ehab M.
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Genes & Nutrition
Background Genetic instability leads to genome mutations, changes in nucleotide sequences, rearrangements, and gains or losses of part of the chromosomes. This instability can initiate and develop cancer. This study evaluated genomic stability in methotrexate and anthocyanin-treated mammary adenocarcinoma model. Seventy albino mice were divided int...
Choi, Woo Jeong Shin, Dayeon
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Genes & Nutrition
Background Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studies (GWAS) suggested that APOA5 gene variants were significantly associated with MetS and its components. Dietary factors such as r...
Tang, Sheau-Chung Hsiao, Yu-Ping Ko, Jiunn-Liang
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Genes & Nutrition
Background Chronic exposure to ultraviolet (UV) rays causes severe skin damage by inducing oxidative stress and inflammation. Identifying a safe and natural substance for skin protection is a crucial research goal. Objective The aim of this study was to clarify the effects of genistein on skin inflammation and photoaging by using 3 models (humans: ...
Peng, Mingjing Fan, Songqing Li, Junjun Zhou, Xiao Liao, Qianjin Tang, Faqing Liu, Wei
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Genes & Nutrition
Background Cancer therapy targeting programmed death receptor-1 (PD-1 or CD279) or programmed death-ligand 1 (PD-L1 or CD274) gives hope to Tongue Squamous Cell Carcinoma (TSCC) treatment. However, the tumor-intrinsic mechanism of PD-L1 is not fully elucidated in TSCC. On the other hand, lycopene showed antitumor effects and chemotherapy/radiothera...
XU, Zhilu JIANG, Wei HUANG, Wenli LIN, Yu CHAN, Francis K.L. NG, Siew C.
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Genes & Nutrition
BackgroundPrevious observational studies have demonstrated inconsistent and inconclusive results of changes in the intestinal microbiota in patients with obesity and metabolic disorders. We performed a systematic review to explore evidence for this association across different geography and populations.MethodsWe performed a systematic search of MED...
Chan, Yap-Hang Schooling, C. Mary Zhao, Jie V. Yeung, Shiu-Lun Au Hai, Jo Jo Thomas, G. Neil Cheng, Kar-Keung Jiang, Chao-Qiang Wong, Yuen-Kwun Au, Ka-Wing
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Published in
Genes & Nutrition
BackgroundVitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serological 25-hydroxyvitamin D [25(OH)D]) confers secondary protection against cardiovascular diseases (CVD) among high-risk hypertensive-di...
Kalafati, Marianthi Kutmon, Martina Evelo, Chris T. van der Kallen, Carla J. H. Schalkwijk, Casper G. Stehouwer, Coen D. A. Consortium, B. I. O. S. Blaak, Ellen E. van Greevenbroek, Marleen M. J. Adriaens, Michiel
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Genes & Nutrition
BackgroundWorldwide, the prevalence of obesity and insulin resistance has grown dramatically. Gene expression profiling in blood represents a powerful means to explore disease pathogenesis, but the potential impact of inter-individual differences in a cell-type profile is not always taken into account. The objective of this project was to investiga...
