Park, Yeeun Ku, Leeyeon Lim, Joo Weon Kim, Hyeyoung
Published in
Genes & Nutrition
BackgroundThe premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrapancreatic zymogen activation and acute pancreatitis. Stimulation of vacuolar ATPase (vATPase) activity is required for zymogen acti...
Jones, Patrice Lucock, Mark Chaplin, George Jablonski, Nina G. Veysey, Martin Scarlett, Christopher Beckett, Emma
Published in
Genes & Nutrition
BackgroundThe frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and genetic disposition. Such interactions could have health implications, where UVB could modulate the impact...
Maynard, Claire Weinkove, David
Published in
Genes & Nutrition
Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but the contribution of these compounds to total uptake is unclear. The role of bacteria in the synthesis and uptake of micronutrients and supple...
Vacca, Francesca Barca, Amilcare Gomes, Ana S. Mazzei, Aurora Piccinni, Barbara Cinquetti, Raffaella Del Vecchio, Gianmarco Romano, Alessandro Rønnestad, Ivar Bossi, Elena
...
Published in
Genes & Nutrition
Following publication of the original article [1], the authors flagged that the ‘Availability of data and materials’ declaration is incomplete.
Ramzan, F. D’Souza, R. F. Durainayagam, B. R. Milan, A. M. Roy, N. C. Kruger, M. C. Henry, C. J. Mitchell, C. J. Cameron-Smith, D.
Published in
Genes & Nutrition
ContextMetabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of the flexibility of post-transcriptional regulation, including circulatory miRNAs (c-miRNAs).DesignThe abundances of targeted c-miRNAs...
Wang, Xiong Zhang, Lin Zhang, Lei Wang, Wenli Wei, Sihan Wang, Jie Che, Huilian Zhang, Yali
Published in
Genes & Nutrition
BackgroundExcessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and development of Caenorhabditis elegans.MethodsWe measured the lifespan, reproductive capacity, and length of nematodes after sugars...
Cuparencu, Cătălina Praticó, Giulia Hemeryck, Lieselot Y. Sri Harsha, Pedapati S. C. Noerman, Stefania Rombouts, Caroline Xi, Muyao Vanhaecke, Lynn Hanhineva, Kati Brennan, Lorraine
...
Published in
Genes & Nutrition
Meat, including fish and shellfish, represents a valuable constituent of most balanced diets. Consumption of different types of meat and fish has been associated with both beneficial and adverse health effects. While white meats and fish are generally associated with positive health outcomes, red and especially processed meats have been associated ...
Williams, Michael B. Watts, Stephen A.
Published in
Genes & Nutrition
This review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated molecular changes. In this review, we provide a synopsis of nutrigenomics using the zebrafish animal model. Obesity and dyslipidemia studies des...
Vacca, Francesca Barca, Amilcare Gomes, Ana S. Mazzei, Aurora Piccinni, Barbara Cinquetti, Raffaella Del Vecchio, Gianmarco Romano, Alessandro Rønnestad, Ivar Bossi, Elena
...
Published in
Genes & Nutrition
BackgroundPeptide transporter 1 (PepT1, alias Slc15a1) mediates the uptake of dietary di/tripeptides in all vertebrates. However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole genome duplication event(s) that occurred during their evolution leading to a more complex paralogue gene repertoire than in hig...
Gjevestad, Gyrd O. Holven, Kirsten B. Rundblad, Amanda Flatberg, Arnar Myhrstad, Mari Karlsen, Karina Mutt, Shivaprakash J. Herzig, Karl-Heinz Ottestad, Inger Ulven, Stine M.
...
Published in
Genes & Nutrition
BackgroundAdequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the optimal intake. To further understand the impact of protein intake on metabolic processes, the aim of the study was to explore gen...
