Liu, Yichuan Chang, Xiao Qu, Hui-Qi Tian, Lifeng Glessner, Joseph Qu, Jingchun Li, Dong Qiu, Haijun Sleiman, Patrick Hakonarson, Hakon
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Genes
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with poorly understood molecular mechanisms that results in significant impairment in children. In this study, we sought to assess the role of rare recurrent variants in non-European populations and outside of coding regions. We generated whole genome sequence (WGS) da...
De Paolis, Elisa Urbani, Andrea Salvatore, Lisa Foca, Laura Tortora, Giampaolo Minucci, Angelo Concolino, Paola
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Genes
Gallbladder carcinoma (GBC) is one of the most aggressive malignancies with poor prognosis and a high fatality rate. The disease presents in advanced stages where the treatment is ineffective. Regarding GBC pathogenesis, as with other neoplasia, this tumor is a multifactorial disorder involving different causative factors such as environmental, mic...
Ceccatelli Berti, Camilla di Punzio, Giulia Dallabona, Cristina Baruffini, Enrico Goffrini, Paola Lodi, Tiziana Donnini, Claudia
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Genes
The increasing application of next generation sequencing approaches to the analysis of human exome and whole genome data has enabled the identification of novel variants and new genes involved in mitochondrial diseases. The ability of surviving in the absence of oxidative phosphorylation (OXPHOS) and mitochondrial genome makes the yeast Saccharomyc...
Rolly, Nkulu Kabange Mun, Bong-Gyu Yun, Byung-Wook
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Genes
A large number of hormonal biosynthetic or signaling pathways genes controlling shoot branching are widely known for their roles in regulating plant growth and development, operating in synergetic or antagonistic manner. However, their involvement in abiotic stress response mechanism remains unexplored. Initially, we performed an in silico analysis...
Arrey-Salas, Oscar Caris-Maldonado, José Carlos Hernández-Rojas, Bairon Gonzalez, Enrique
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Genes
Some C2H2 zinc-finger proteins (ZFP) transcription factors are involved in the development of pollen in plants. In grapevine (Vitis vinifera L.), it has been suggested that abnormalities in pollen development lead to the phenomenon called parthenocarpy that occurs in some varieties of this cultivar. At present, a network involving several transcrip...
Kumar, Vishesh Jain, Priyanka Venkadesan, Sureshkumar Karkute, Suhas Gorakh Bhati, Jyotika Abdin, Malik Zainul Sevanthi, Amitha Mithra Mishra, Dwijesh Chandra Chaturvedi, Krishna Kumar Rai, Anil
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Genes
Rice blast is a global threat to food security with up to 50% yield losses. Panicle blast is a more severe form of rice blast and the response of rice plant to leaf and panicle blast is distinct in different genotypes. To understand the specific response of rice in panicle blast, transcriptome analysis of blast resistant cultivar Tetep, and suscept...
Lee, Yeonmi Kim, Taeho Lee, Miju So, Seongjun Karagozlu, Mustafa Zafer Seo, Go Hun Choi, In Hee Lee, Peter C. W. Kim, Chong-Jai Kang, Eunju
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Genes
Defects in the mitochondrial genome (mitochondrial DNA (mtDNA)) are associated with both congenital and acquired disorders in humans. Nuclear-encoded DNA polymerase subunit gamma ( POLG ) plays an important role in mtDNA replication, and proofreading and mutations in POLG have been linked with increased mtDNA deletions. SSBP1 is also a crucial gene...
Türksever, Cengiz López Torres, Lisette T Valmaggia, Christophe Todorova, Margarita G
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Genes
(1) Background: The aim of our study was to investigate the relationship between retinal metabolic alterations (retinal vessel oximetry, RO) and structural findings (retinal vessel diameter, central retinal thickness and retinal nerve fiber layer thickness, RNFL) in patients with inherited retinal diseases (IRDs). (2) Methods: A total of 181 eyes o...
Mehrban, Hossein Naserkheil, Masoumeh Lee, Deuk Hwan Cho, Chungil Choi, Taejeong Park, Mina Ibáñez-Escriche, Noelia
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Genes
The weighted single-step genomic best linear unbiased prediction (GBLUP) method has been proposed to exploit information from genotyped and non-genotyped relatives, allowing the use of weights for single-nucleotide polymorphism in the construction of the genomic relationship matrix. The purpose of this study was to investigate the accuracy of genet...
Mansoori, Behzad Silvestris, Nicola Mohammadi, Ali Khaze, Vahid Baghbani, Elham Mokhtarzadeh, Ahad Shanehbandi, Dariush Derakhshani, Afshin Duijf, Pascal H G Baradaran, Behzad
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Published in
Genes
Breast cancer is the most common women's malignancy in the world and, for subgroups of patients, treatment outcomes remain poor. Thus, more effective therapeutic strategies are urgently needed. MicroRNAs (miRNAs) have emerged as promising therapeutic tools and targets, as they play significant roles in regulating key cellular processes by suppressi...
