Karkache, Ismael Y Damodaran, Jeyaram R Molstad, David H H Bradley, Elizabeth W
Published in
Gene
Maintenance of optimal bone mass is controlled through the concerted functions of several cell types, including bone resorbing osteoclasts. Osteoclasts function to remove calcified tissue during developmental bone modeling, and degrade bone at sites of damage during bone remodeling. Changes to bone homeostasis can arise with alterations in osteocla...
Hoshino, Kunikazu Maeshiro, Tatsuji Nishida, Nao Sugiyama, Masaya Fujita, Jiro Gojobori, Takashi Mizokami, Masashi
Published in
Gene
An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred aboard the Diamond Princess cruise ship between her January 20 departure and late February 2020. Here, we used phylodynamic analyses to investigate the transmission dynamics of SARS-CoV-2 during the outbreak. Using a Ba...
Sharma, Abhay
Published in
Gene
Laskar, Rezwanuzzaman Ali, Safdar
Published in
Gene
Mutational status of SARS-CoV-2 genomes from India along with their impact on proteins was ascertained through multiple tools including MEGA, Genome Detective, SIFT, PROVEAN and ws-SNPs&GO. Excluding gaps and ambiguous sequences, 493 variable sites (152 parsimony informative and 341 singleton) were observed. NSP3 had the highest incidence of 101 si...
Saburi, Ehsan Abazari, Mohammad Foad Hassannia, Hadi Mansour, Reyhaneh Nassiri Eshaghi-Gorji, Reza Gheibi, Mobina Rahmati, Mohammad Enderami, Seyed Ehsan
Published in
Gene
In addition to causing health concerns, the new coronavirus has been considered in the world with its unknown mechanism of physiopathogenesis and long-term effects after patient recovery. Pulmonary, renal, hepatic and cardiac complications have been reported so far. Beside the researchers' focus on finding vaccines and using conventional therapies,...
Nail, Alexandra N Spear, Brett T Peterson, Martha L
Published in
Gene
The mammalian Cytochrome P450 (Cyp) gene superfamily encodes enzymes involved in numerous metabolic pathways and are frequently expressed in the liver. Despite the remarkably high sequence similarity of Cyp2a4 and Cyp2a5 genes and their surrounding genomic regions, they exhibit differences in expression in the adult mouse liver. For example, Cyp2a4...
Kuveljic, Jovana Djuric, Tamara Stankovic, Goran Dekleva, Milica Stankovic, Aleksandra Alavantic, Dragan Zivkovic, Maja
Published in
Gene
Myocardial infarction (MI) and underlining atherosclerosis are the main causes of death worldwide. Phosphatase and actin regulator 1 (PHACTR1) variants have been associated with early onset MI, coronary artery disease and carotid dissection. PHACTR1 mRNA expression has been detected in tissues and cells related to atherosclerosis. Nonetheless, the ...
Lai, Zhenyu Wu, Fei Li, Mei Bai, Fuxia Gao, Yuan Yu, Jie Li, Haijing Lei, Chuzhao Dang, Ruihua
Published in
Gene
Insulin-like growth factor 1 (IGF1) is a multifunctional cell proliferation regulator that plays a critical role in regulating animal growth and development. In this study, the expression level of IGF1 gene in different tissues of Dezhou donkey in different periods was investigated by RT-qPCR. Meanwhile, two mutation sites were identified within th...
Badreldin, Amr A Bagheri, Leila Zhang, Bangke Larson, A Noelle van Wijnen, Andre J
Published in
Gene
Control of gene expression by epigenetic regulators is fundamental to tissue development and homeostasis. Loss-of-function (LOF) studies using siRNAs for epigenetic regulators require that RNA interference rapidly reduces the cellular levels of the corresponding mRNAs and/or proteins. The most abundant chromatin structural proteins (i.e., the core ...
Tandon, Manish Othman, Ahmad H Winogradzki, Marcus Pratap, Jitesh
Published in
Gene
Breast cancer is the most commonly diagnosed cancer among women and its metastases results in poor survival rates in patients. The ability to alter metabolism is a key attribute cancer cells use to survive within different metastatic microenvironments and cause organ failure. We hypothesized that evaluation of metabolic alterations within tumor cel...